The association between clinical and laboratory parameters in thyroid disease and nonthyroidal illness in young women.

OBJECTIVE: Evidence from epidemiological and clinical studies strongly suggest that young women in the preconception period are a group at risk for thyroid disorders which may lead to further aggravation of pre-existing chronic thyroid disease and complications during pregnancy. MATERIALS AND METHODS: This paper is a literature review focusing on articles published in English between 2014-2017 searched in Medline database using terms 'young women', 'subclinical hyperthyroidism', 'subclinical hypothyroidism', 'nonthyroidal illness syndrome', 'obesity', 'depression'. CONCLUSIONS: Clinical assessment of young female patient including that of obtaining full medical history with a focus on the perceived changes in appearance, psychological symptoms and menstrual irregularities supported by laboratory tests indicative of metabolic status and characteristic changes in thyroid functions, may be the key to well-reasoned and justified individual therapeutic decisions.

Molecular epidemiology and evolution of A(H1N1) pdm09 and H3N2 viruses in Jordan, 2011-2013.

Understanding the genetic evolution of A(H1N1)pdm09 and H3N2 viruses can help better select strains to be included in the annual influenza vaccine. There is little information on their evolution in Jordan so this study investigated the genetic and antigenic variability of A(H1N1)pdm09 and H3N2 viruses in Jordan by performing phylogenetic and genetic analyses of the HA and NA genes of A(H1N1)pdm09 and H3N2 viruses between 2011 and 2013. The full HA and NA genes of 16 H1N1-positive samples obtained in our study and 21 published HA sequences and 20 published NA sequences from Jordanian viruses that were available on online gene databases were analysed. For H3N2, we generated 20 HA and 19 NA sequences and included 19 published HA and NA sequences each in the analysis. Jordanian H1N1 viruses had mutations that are characteristic of antigenic group 6 while H3N2 virus mutations belonged to group 3. No markers of resistance to oseltamivir were detected. The individual mutations are described in detail.

Molecular epidemiology and evolution of A[H1N1] pdm09 and H3N2 viruses in Jordan, 2011-2013

Understanding the genetic evolution of A [H1N1]pdm09 and H3N2 viruses can help better select strains to be included in the annual influenza vaccine. There is little information on their evolution in Jordan so this study investigated the genetic and antigenic variability of A[H1N1]pdm09 and H3N2 viruses in Jordan by performing phylogenetic and genetic analyses of the HA and NA genes of A[H1N1]pdm09 and H3N2 viruses between 2011 and 2013. The full HA and NA genes of 16 H1N1-positive samples obtained in our study and 21 published HA sequences and 20 published NA sequences from Jordanian viruses that were available on online gene databases were analysed. For H3N2, we generated 20 HA and 19 NA sequences and included 19 published HA and NA sequences each in the analysis. Jordanian H1N1 viruses had mutations that are characteristic of antigenic group 6 while H3N2 virus mutations belonged to group 3. No markers of resistance to oseltamivir were detected. The individual mutations are described in detail

La compréhension de l'évolution génétique des virus A[H1N1]pdm09 et H3N2 permet de mieux sélectionner les souches devant être ajoutées au vaccin antigrippal annuel. Peu de renseignements sont disponibles sur les mutations des virus saisonniers de la grippe A[H1N1]pdm09 et H3N2 en Jordanie. Afin de remédier à ce problème et d'étudier les variations génétiques et antigéniques des virus A[H1N1]pdm09 et H3N2, nous avons procédé à des analyses génétiques et phylogénétiques des gènes de l'hémagglutinine [HA] et de la neuraminidase [NA] de ces virus, sur la période 2011-2013 en Jordanie. L'analyse a porté sur les séquences complètes des gènes de l'HA et de la NA de 16 échantillons positifs au virus H1N1 prélevés dans le cadre de cette étude, ainsi que sur 21 séquences publiées de l'HA et 20 séquences publiées de la NA, issues de virus jordaniens disponibles sur les bases de données de gènes en ligne. Pour le virus H3N2, nous avons généré 20 séquences de l'HA et 19 de la NA, et avons également inclus dans l'analyse 19 séquences publiées de l'HA et 19 de la NA. Les virus H1N1 jordaniens présentaient des mutations caractéristiques du groupe antigénique 6, tandis que les virus H3N2 appartenaient au groupe 3. Aucun marqueur de résistance à l'oseltamivir n'a été détecté. Les mutations individuelles sont décrites en detail

Risk factors for neonatal intensive care unit admission in Amman, Jordan.

A better understanding of risk factors for neonatal intensive care unit (NICU) admission can inform interventions to improve neonatal survival. This study aimed to describe a population of newborns admitted to a NICU in Amman, Jordan, and compare them with newborns discharged to home. Newborns born within 96 hours at Al-Bashir Hospital were enrolled from February 2010 to June 2011. Demographic and clinical data were collected for mothers and newborns. Of 5466 enrolled neonates, 373 (6.8%) were admitted to the NICU. The median gestational age of NICU infants was 36 weeks, median birth weight was 2.2 kg and 49.5% were delivered by non-elective caesarean section. Lower gestational age, lower birth weight, delivery by caesarean section and birth in the month of May were statistically significant risk factors for NICU admission. Risk factors for NICU admission were consistent with other populations worldwide; however, median gestational age and birth weight were higher than in developed countries.

Risk factors for neonatal intensive care unit admission in Amman, Jordan

A better understanding of risk factors for neonatal intensive care unit [NICU]admission can inform interventions to improve neonatal survival.This study aimed to describe a population of newborns admitted to a NICU in Amman Jordan,and compare them with newborns discharged to home.Newborns born within 96 hours at Al-Bashir Hospital were enrolled from February 2010 to June 2011.Demographic and clinical data were collected for mothers and newborns.Of 5466 enrolled neonates,373 [6.8%]were admitted to the NICU.The median gestational age of NICU infants was 36 weeks,median birth weight was 2.2 kg and 49.5% were delivered by non-elective caesarean section.Lower gestational age,lower birth weight,delivery by caesarean section and birth in the month of May were statistically significant risk factors for NICU admission.Risk factors for NICU admission were consistent with other populations worldwide;however,median gestational age and birth weight were higher than in developed countries

ان فهما افضل لعوامل خطر ادخال حديثي الولادة الى وحدة العنايه المركزة يمكن أن يرشد الى تدخلات تحسن من بقاء حديثي الولادة على قيد الحياه وقد هدفت هذه الدراسه الى بيان حاله مجموعة من حديثي الولادة الذين ادخلوا الى وحدة العنايه المركزة في عمان بالاردن ومقارنتهم مع حديثي الولادة خرجوا من المزل فتم تسجيل حديثي الولادة خلال 96 ساعه في مستشفي البشير استباقيا من شباط / فبراير 2010 حتى حزيران / يونيو 2011 وجمعت البيانات السكنيه والسريريه للامهات وحديثي الولادة من اصل 5466 حديثي ولادة مسجلين تم ادخال 373 (6.8%)الى وحدة العنايه المركزة وكان متوسط العمر الحملي للرضع الذين ادخلوا الى وحدة العنايه المركزة 36 اسبوعا ووسطى وزن الوليد 2.2 كجم وولد 49.5% منهم بعمليه قيصريه غير انتقائيه . انخفاض العمر الحملي وانخفاض وزن الوليد والولادة بعمليه قيصريه والولادة في شهر ايار/ مايو كانت عوامل خطر ذات دلالة احصائيه للادخال الى وحدة العناية المركزة . ان عوامل خطر ادخال حديثي الولادة الى وحدة العنايه المركزة كانت متماشيه مع شعوب اخري في العالم غير أن متوسط العمر الحملي ووزن حديثي الولادة كانا اعلى مما هما عليه في البلدان المتقدمة

Une meilleure comprehension des facteurs de risque pour ('admission en unite de soin intensifs neonatals permet d'orienter les interventions en vue d'arneliorer la survie des nouveau-nes.La presente etude avait pour objectif de decrire une population de nouveau-nes ad mis en unite de soins intensifs neonatals a Amman [Jordanie]et de mener une etude comparative avec des nouveau-nes rentres a domicile.Les nouveau-nes dont la naissance est survenue dans un laps de temps de 96 heures apres leur entree a Thopital Al-Bashir ont participe a I'etude entre fevrier 2010 et juin 2011.Des donnees demographiques et cliniques ont ete collectees pour les meres et les nouveau-nes.Sur 5 466 nouveau-nes,373 [6,8 %]ont ete admis en unite de soins intensifs neonatals.L'age gestationnel median des enfants admis dans I'unite etait de 36 semaines,le poids median a la naissance etait de 2,2 kg et 49,5 % d'entre eux etaient nes par cesarienne non elective.Un age gestationnel plus bas,un poids a la naissance plus faible,une naissance par cesarienne et la naissance au cours du mois de mai constituaient des facteurs de risque statistiquement significatifs pour une admission dans I'unite.Ces facteurs de risque co'mcidaient avec ceux d'autres populations dans le monde,mais Tage gestationnel et le poids a la naissance medians etaient plus eleves que dans les pays developpes

Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012.

Hospitalized children < 2 years of age in Amman, Jordan, admitted for fever and/or respiratory symptoms, were tested for Middle East respiratory syndrome coronavirus (MERS-CoV): MERS-CoV by real-time RT-PCR (rRT-PCR). This was a prospective year-round viral surveillance study in children <2 years of age admitted with acute respiratory symptoms and/or fever from March 2010 to September 2012 and enrolled from a government-run hospital, Al-Bashir in Amman, Jordan. Clinical and demographic data, including antibiotic use, were collected. Combined nasal/throat swabs were collected, aliquoted, and frozen at -80°C. Specimen aliquots were shipped to Vanderbilt University and the Centers for Disease Control and Prevention (CDC), and tested by rRT-PCR for MERS-CoV. Of the 2433 subjects enrolled from 16 March 2010 to 10 September 2012, 2427 subjects had viral testing and clinical data. Of 1898 specimens prospectively tested for other viruses between 16 March 2010 and 18 March 2012, 474 samples did not have other common respiratory viruses detected. These samples were tested at CDC for MERS-CoV and all were negative by rRT-PCR for MERS-CoV. Of the remaining 531 samples, collected from 19 March 2012 to 10 September 2012 and tested at Vanderbilt, none were positive for MERS-CoV. Our negative findings from a large sample of young Jordanian children hospitalized with fever and/or respiratory symptoms suggest that MERS-CoV was not widely circulating in Amman, Jordan, during the 30-month period of prospective, active surveillance occurring before and after the first documented MERS-CoV outbreak in the Middle East region.

Influenza vaccination in the organ transplant recipient: review and summary recommendations.

Influenza virus causes a spectrum of illness in transplant recipients with a high rate of lower respiratory disease. Seasonal influenza vaccination is an important public health measure recommended for transplant recipients and their close contacts. Vaccine has been shown to be safe and generally well tolerated in both adult and pediatric transplant recipients. However, responses to vaccine are variable and are dependent on various factors including time from transplantation and specific immunosuppressive medication. Seasonal influenza vaccine has demonstrated safety and no conclusive evidence exists for a link between vaccination and allograft dysfunction. Annually updated trivalent inactivated influenza vaccines have been available and routinely used for several decades, although newer influenza vaccination formulations including high-dose vaccine, adjuvanted vaccine, quadrivalent inactivated vaccine and vaccine by intradermal delivery system are now available or will be available in the near future. Safety and immunogenicity data of these new formulations in transplant recipients requires investigation. In this document, we review the current state of knowledge on influenza vaccines in transplant recipients and make recommendations on the use of vaccine in both adult and pediatric organ transplant recipients.