A retrospective study on pathological and clinical characteristics of 52 cases with the colorectal serrated polyp.

BACKGROUND AND OBJECTIVE: Colorectal serrated polyp is considered as histologically heterogeneous lesions with malignant potential. The aim of the study was to evaluate the endoscopic, clinic and pathologic characteristics of colorectal serrated polyps. METHODS: The endoscopic, clinic and pathologic characteristics of 52 cases with colorectal serrated polyps between January 2014 and May 2018 in our hospital were analyzed. retrospectively. RESULTS: The prevalence of serrated polyps was 0.39% (52/13,346). The proportions of hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P), and traditional serrated adenoma (TSA) of all serrated polyps were 61.5%, 17.3%, and 21.2%, respectively, which showed a lower proportion of TSA and SSA/P and a higher proportion of HP. CONCLUSIONS: The overall detection rate of colorectal serrated polyps was relatively low, and it is necessary to discriminate between SSAPs and HPs during endoscopic examination because of the malignant potential.

Effect of Bailing capsule on the patients with stable chronic obstructive pulmonary disease / 新乡医学院学报

Objective To investigate the effect and mechanism of Bailing capsule on the patients with stable chronic obstructive pulmonary disease (COPD).Methods A total of 100 patients with more than two weeks of stable COPD were selected from January 2013 to June 2016 in the Department of Respiratory Medicine,the First Affiliated Hospital of Xinxiang Medical University.The patients were randomly divided into the control group and the observation group,with 50 cases in each group.The patients in the control group were treated with tiotropium bromide powder for inhalation,and the patients in the observation group were treated with Bailing capsule orally on the basis of tiotropium bromide powder for inhalation,the patients in the two groups were treated for 12 months.The clinical effect and the average number of acute exacerbations within one year were compared between the two groups;and the level of serum amyloid A (SAA) were compared between the two groups before treatment and 3,6 and 12 months after treatment.Results The total effective rate in the observation group (84.0％) was significantly higher than that in the control group (72.0％)after 12 months of treatment (x2 =4.097,P ＜ 0.05).The average number of acute exacerbations in the observation group within one year was significantly less than that in the control group (P ＜ 0.01).There was no significant difference in serum SAA level between the two groups before treatment and 3 months after treatment (P ＞ 0.05).The serum SAA level in the observation group was significantly lower than that in the control group at the time points of 6 and 12 months after treatment (P ＜ 0.05).There was no significant difference in serum SAA level between before treatment and 3 months after treatment in the two groups (P ＞ 0.05).The serum SAA level at 6 and 12 months after treatment was significantly lower than that before treatment and 3 months after treatment in the two groups (P ＜ 0.05).The serum SAA level at 12 months of treatment was significantly lower than that at 6 months of treatment in the two groups (P ＜ 0.05).Conclusion Bailing capsule can inhibit the inflammatory reaction of COPD patients by interfering with the secretion of serum SAA,so as to improving the clinical manifestations of COPD patients and reducing the acute attack of COPD.

Endoscopic color doppler ultrasonography in predicting the safety of endoscopic submucosal dissection for antral heterotopic pancreas.

BACKGROUND/AIMS: Complications are important determining factors for safety of endoscopic submucosal dissection (ESD) for gastric heterotopic pancreas (HP). This study investigated whether endoscopic color Doppler ultrasonography (ECDUS) could be used to predict the feasibility, efficacy, and safety of ESD. PATIENTS AND METHODS: The study included 52 patients with heterotopic pancreas of the gastric antrum who underwent ECDUS before ESD. ECDUS was used to evaluate the submucosal vascular structure and the location of HP in gastric wall. The patients who had a vessel at least 500 µm in diameter or at least 10 vascular structures per field of view were classified into the rich group (Group R), and others were classified into the non-rich group (Group N). Procedure time, decrease in hemoglobin, frequency of clip use, complications, recurrence rate, and others were retrospectively evaluated. RESULTS: There were 18 patients in Group R and 34 patients in Group N. Mean procedure time was significantly longer in group R (55.4 min) than in group N (35.5 min) (P = 0.014). The incidence of muscle injury and clip use were significantly higher in group R (77.8/83.3%) than in group N (20.6/23.5%) (P < 0.05). Mean decrease in hemoglobin was 2.5 g/dL in group R and 2.4 g/dL in group N, with no significant difference. There were no recurrences in any cases during the follow-up period. CONCLUSION: Preoperative identification of submucosal vascular structure by ECDUS can predict procedure time and the incidence of muscle injury and clip use, which is particularly suitable for predicting ESD safety in heterotopic pancreas of stomach.

Using a double-channel gastroscope reduces procedural time in performing gastric endoscopic submucosal dissection.

OBJECTIVE: Complications are important determining factors for safety of endoscopic submucosal dissection (ESD). ESD of large lesions is associated with increased procedural time. This study investigated whether double-channel gastroscope could be used to reduce procedural time in gastric antrum ESD. METHODS: A retrospective cohort study of 46 patients with one gastric antrum lesion resected by ESD was conducted between January 2013 and December 2015. The diameter of a lesion was from 2cm to 4cm in 46 patients. EUS before ESD was used to evaluate the submucosal vascular structure and the location of lesion in gastric wall. Forty six lesions had ESD with either the ordinary gastroscope (OS group) (n=24) or the double-channel gastroscope (DC group) (n=22). RESULTS: The mean procedural time was significantly lower in the DC group than in the OS group (49.1 minutes vs. 20.5 minutes, p=0.04). There were no significant differences in submucosal injection frequency, specimen size, en bloc resection rate and perforation rate between the two endoscopic groups. There was no recurrence in any case during the follow-up period. CONCLUSIONS: Our data suggest that ESD utilizing double-channel gastroscope may provide a better platform for quicker ESD with equal safety.