[Effect of propranolol on the cardiac rhythm variability and the cardiac cycle phase structure in healthy volunteers]. / Vliianie propranolola na variabel'nost' serdechnogo ritma i fazovuiu strukturu serdechnogo tsikla u zdorovykh dobrovol'tsev.

In an acute pharmacological test in 13 healthy volunteers (24 +/- 4) years old effects were studied of propranolol, 40 mg/50 kg body mass, on the sympathovagal regulation and phase patterns of the cardiac cycle. The study was made with the aid of the computer electrocardiograph "Cardiolab 2000" at the height of the propranolol effect by standard methods. The state of the sympathovagal regulation was assessed by the heart's rhythm variability technique with respect to the spectrum lowfrequency and highfrequency ranges powers. There have been measured duration of the P-wave, PQ-interval, QRS-complex, QT-interval to analyze phase patterns of the cardiac cycle. One-dose intake of propranolol has been shown to optimize the sympathovagal balance by boosting the influence of that portion of the autonomic nervous system, whose baseline activity has been shown to be slight. Optimization of the sympathovagal balance was accompanied by general enhancement of the level of neurohumoral regulation. Effect of propranolol on the phase patterns of the cardiac cycle was invariant from the baseline state and from subsequent changes in the sympathovagal balance.

[The clinical picture of internal diseases in the light of immunology]. / Klinika vnutrennikh boleznei v svete immunologii.

Clinical profiles of internal diseases are examined from the immunological standpoint together with the causes for creation by immunology of its own clinical base. It is shown that the approach common in immunology, based on the fundamental notions of the immunity system offers superior efficacy and should be recommended in dealing with internal diseases in a clinical setting.

[The characteristics of the clinical manifestations of chronic hepatitis and liver cirrhosis depending on the structure of the inflammatory infiltrate in the liver tissue]. / Osobennosti klinicheskikh proiavlenii khronicheskogo gepatita i tsirroza pecheni v zavisimimosti ot strktury vospalitel'nogo infil'trata v tkani pecheni.

A study is presented of 107 patients with chronic hepatitis and liver cirrhosis verified on the basis of morphological changes of the punctate obtained at echocontrol puncture liver biopsy. It was established that clinical manifestations of chronic hepatitis and liver cirrhosis are determined not only by their morphological forms, but also by the structure of the inflammatory infiltrate of the liver tissue. This is to be considered in evaluation of the severity of the disease course and differentiated treatment.

[Calcium and calcium-channel blockers in the healing of an experimental myocardial infarct]. / Kal'tsii i blokatory kal'tsievykh kanalov pri zazhivlenii éksperimental'nogo infarkta miokarda.

It has been shown in experiments on 36 dogs with experimental myocardial infarction (MI) that the effect of calcium and blockers of calcium channels largely depends on the initial condition of reactivity and is realized via changes in lipid peroxidation (LPO). In MI, calcium enhances necrotic processes whereby aggravating disorders in its healing in case of high reactivity and returns them to normal, thus contributing to optimization of its healing in animals with low reactivity. Calcium channels blockers attenuate necrotic processes associated with MI and lead to its better healing in the presence of high reactivity and aggravate disorders in its healing in animals with low reactivity. Consideration of the body reactivity, the differentiated use of calcium drugs and calcium channels blockers should be regarded as an effective approach to optimization of the healing of complicated forms of MI.

[Kinetics of myoglobin, creatine kinase and aspartate aminotransferase in uncomplicated and complicated forms of healing of experimental myocardial infarction]. / Kinetika mioglobina, kreatinkinazy i aspartataminotransferazy pri neoslozhnennom i oslozhnennykh formakh zazhivleniia infarkta miokarda v éksperimente.

It was demonstrated in experiments on 60 dogs that in hyporeactive myocardial infarction (MI) myoglobin (MG) concentration and the activity of creatine kinase (CK) and aspartate aminotransferase (ASAT) increase at a slower rate and reach maximum values later. In hyperreactive MI the rate of their increase and the time of attainment of maximum values are, respectively, greater and earlier than in normoreactive MI. The connection of MG, CK, and ASAT changes with reactivity allows them to be used in prognosticating MI healing.

[Biochemical characteristics of uncomplicated and complicated healing of experimental myocardial infarcts]. / Biokhimicheskaia kharakteristika neoslozhnennogo i oslozhnennykh form zazhivlenia éksperimental'nogo infarkta miokarda.

Myocardial infarction was simulated in experiments with 138 dogs showing normal, high, and low responses. The kinetics of creatine kinase as a marker of necrotic processes in myocardial infarction was shown to accelerate with hyperreactivity and to slow down with hyporeactivity. The kinetics of u-glutamyl transpeptidase as a marker of reparative processes in myocardial infarction was characterized by delayed and slower evolution in hyper- and hyporeactivity. The kinetics of dienic conjugates, cyclic nucleotides (cAMP, cGMP) and immunoreactive insulin was also determined largely by the body's reactivity and the types of experimental myocardial infarction healing and was closely related to that of enzymatic markers of necrotic processes.

[Blood plasma diene conjugates during the stimulation and inhibition of lipid peroxidation in dogs with different forms of healing in experimental myocardial infarct]. / Dienovye kon''iugaty plazmy krovi pri stimuliatsii i ingibirovanii perekisnogo okisleniia lipidov u sobak s razlichnymi formami zazhivleniia éksperimental'nogo infarkta miokarda.

In experiments on 45 dogs with a model of normo-, hyper-, and hyporeactive myocardial infarction, (MI) lipid peroxidation (LP) was stimulated by ultraviolet irradiation of autologous blood and inhibited by alpha-tocopherol acetate. It is shown that changes of LP are characteristic of uncomplicated healing of normoreactive MI. Hyperactivation of LP in hyperreactive MI and its hypoactivation in hyporeactive MI are among the factors of complication of its healing by postinfarction aneurysm of the heart. LP modulation consisting in bringing its changes in conformity with those in uncomplicated forms of the disease facilitates normal MI healing with the formation of a postinfarction scar. Antioxidants are indicated in hyperreactive MI, and LP activation by means of stimulators is recommended in hyporeactive MI.

[Eicosanoids in chronic liver diseases]. / Eikozanoidy pri khronicheskikh zabolevaniiakh pecheni.

Serum levels of eicosanoids in patients suffering from chronic hepatic diseases were analysed in correlation with morphological characteristics of the hepatic lesion, body reactivity, manifestations of the alternative and immune phases of the inflammation. The results could be contributing to diagnosing and treating chronic inflammation in the liver.

[The effect of hyperglycemia on the development of experimental myocardial infarct]. / Vliianie giperglikemii na razvitie éksperimental'nogo infarkta miokarda.

Experiment on 72 dogs has shown that myocardial infarction (M1) against a background of hyperglycemia proceeds as shifts healing hyperactive MI. Shifts in carbohydrate metabolism results in disturbances of dynamics of the necrotic infarction zone processes that induces complications of healing changes in the content of myoglobin, creatine kinase, aspartateaminotransferase with MI against a background of hyperglycemia greatly differ from those typical of noncomplicated and complicated hyperactive MI.

[The efficacy of glucosamine in treating complicated hyperreactive experimental myocardial infarct]. / Effektivnost' gliukozamina v lechenii oslozhnennogo giperreaktovnogo éksperimental'nogo infarkta miokarda.

The effect of glucosamine hydrochloride on the course of complicated hyperreactive myocardial infarction in dogs was studied. Glucosamine contributed to the restoration of reactivity in the animals. The reactivity became corresponding for normoreactive myocardial infarction. Glucosamine normalized carbohydrate and protein metabolism in the necrosis zone, cAMP and cGMP and also their ratio that led to healing by postinfarction scar, and in none of the cases the heart aneurysm developed. The optimizing healing of hyperreactive myocardial infarction under the influence of glucosamine is mediated through the mechanisms of reactivity and the regulation of metabolic processes.

[The clinical manifestations and the plasma levels of fibronectin and fibrin-fibrinogen degradation products in different morphological forms of chronic hepatitis]. / Klinicheskie proiavleniia, soderzhanie fibronektina, produktov degradatsii fibrina i fibrinogena plazmy pri razlichnykh morfologicheskikh formakh khronicheskikh gepatitov.

The paper provides the results of studying the clinical disease manifestations, the plasma content of fibronectin and fibrin and fibrinogen degradation products in patients with chronic hepatitis (CH). It is shown that they are determined not only by the morphological form of CH but also by the structure of inflammatory infiltrates in liver tissue.

[The expediency of optimizing lipid peroxidation in treating complicated forms of myocardial infarct healing]. / O tselesoobraznosti optimizatsii perekisnogo okisleniia lipidov v lechenii oslozhnennykh form zazhivleniia infarkta miokarda.

Experiments on 36 dogs revealed a relationship of inhibition and stimulation of lipid peroxidation (LPO) and reactivity of myocardial infarction (MI) concerning outcomes of healing. It is shown that in complicated IM it is necessary to optimize LPO turning its dynamics to uncomplicated disease forms. In hyperreactive MI it is judicious to use antioxidants while in hyporeactive LPO stimulation is indicated using ultraviolet radiation of the blood.

[Fibronectin in acute and chronic hepatitis]. / Fibronectin pri ostrom i khronicheskom gepatite.

Changes in plasma fibronectin in acute and chronic viral hepatitides have been investigated in 125 patients. In acute and chronic viral hepatitis B plasma fibronectin level lowered in parallel with changes in the disease severity.

[Effect of reactivity disorders on the healing process in myocardial infarction]. / Vliianie narushenii reaktivnosti na protsess zazhivleniia infarkta miokarda.

Normo-, hyper-, and hyporeactive myocardial infarction was modelled in experiments on 38 dogs. Reactivity disorders complicating healing of the infarct are mediated through desynchronization of the necrotic and reparative processes. Increase of reactivity leads to acceleration, while its diminution leads to deceleration of the necrotic processes with delay in the development of reparative processes.

[Blood plasma diene conjugates in uncomplicated and complicated forms of the healing of experimental myocardial infarct]. / Dienovye kon''iugaty plazmy krovi pri neoslozhnennom i oslozhnennykh formakh zazhivleniia éksperimental'nogo infarkta miokarda.

The experiment on 39 dogs has shown that in MI the concentration dynamics of conjugates in the blood plasma is in accordance with the forms of its healing and has two periods of activation related, respectively, to necrotic processes and development of granular tissue in the infarction zone. The control over the changes of peroxide lipid oxidation (PLO) in MI may be regarded as one of the methods of diagnosing and foreseeing the outcomes of its healing. In optimization of MI healing, to modulate PLO appears to be advisable, that is, to make its course typical of noncomplicated MI.

[The role of inflammation in the reparative process in experimental myocardial infarction]. / Rol' vospaleniia v vosstanovitel'nom protsesse pri éksperimental'nom infarkte miokarda.

Experiments carried out on 91 dogs have shown that changes in the inflammatory process course result in complicated postinfarction repair of myocardium, disagreement in the development, i.e. in desynchronization of necrotic repair processes in the myocardial infarction zone. It is supposed that regulation of the myocardial infarction healing by inflammation can be one of the efficient methods of its therapy.