Efficacy of platelet-rich plasma applied to post-extraction retained lower third molar alveoli. A systematic review.

UNLABELLED: Dental retentions have a high prevalence among the general population and their removal can involve multiple complications. The use of platelet rich plasma has been proposed in an attempt to avoid these complications, as it contains high growth factors and stimulates diverse biological functions that facilitate the healing of soft and hard tissues. OBJECTIVES: To evaluate the available scientific evidence related to the application of platelet-rich plasma in the post-extraction alveoli of a retained lower third molars. MATERIAL AND METHODS: A systematic review of published literature registered in the Medline, EMBASE, Cochrane and NIH databases. The following categories were included: human randomized clinical studies. Key search words were: platelet rich plasma; platelet rich plasma and oral surgery; platelet rich in growth factors and third molar. RESULTS: Of 101 potentially valid articles, seven were selected, of which four were rejected as they failed to meet quality criteria. Three studies fulfilled all selection and quality criteria: Ogundipe et al.; Rutkowski et al.; Haraji et al. The studies all measured osteoblast activity by means of sintigraphy, and also registered pain, bleeding, inflammation, temperature, numbness as perceived by the patients, radiological bone density and the incidence of alveolar osteitis. CONCLUSIONS: Scientific evidence for the use of PRP in retained third molar surgery is poor. For this reason randomized clinical trials are needed before recommendations for the clinical application of PRP can be made.

Epidemiology and treatment of adenoid cystic carcinoma of the minorsalivary glands: A meta-analytic study

Objectives: To evaluate the epidemiological aspects of adenoid cystic carcinoma (ACC) and to evaluate the differenttherapeutic possibilities as well as the percentage of survival.Study Design: A retrospective, meta-analytic, observational study was carried out by selecting a total of 13 articles,which provided a sample size of 263 cases of patients who had been diagnosed with ACC in the minorsalivary glands.Results: ACC was found to be more common among women (56.5%) and the average age at diagnosis was 55.26years old. The primary location of the tumor was in the palate in 57% of the cases, the predominant pattern beingcribiform. The treatment of choice was therapy combined with surgery and radiotherapy in 62.7% of the subjects.The overall survival rate was 70.76% and 56.76%, at 5 and 10 years respectively.Conclusions: Early detection of adenoid cystic carcinoma is necessary in order to enable making an earlier prognosis and thus enable a better quality of life for the patient (AU)

[Dermatologic preparations with erythromycin--the correlation of the pharmaceutical form-therapeutic effect]. / Dermopreparate cu eritromicina--corelatia forma farmaceutica-effect terapeutic.

Erythromycin associated with progesterone and A vitamin has been included in three dermatological pharmaceutical forms: a lotion, a L/H emulsion and a L/H nonionogenic ointment. Aspect of these preparations has been noticed for a 90 days period. pH and electrical conductance were also determined during this interval. All the formulations mentioned above revealed insignificant variations of these parameters proving an appreciable physico-chemical stability. Clinical investigative studies in juvenile acne, showed efficiency, particularly for the emulsion form.