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1.
Molecules ; 24(2)2019 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-30658485

RESUMO

Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A⁻E (1⁻5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1⁻5 were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC50 ranging from 5.9 to 33.9 µM compared to Cisplatin.


Assuntos
Cucurbitaceae/química , Glicosídeos/farmacologia , Tubérculos/química , Triterpenos/farmacologia , Morte Celular/efeitos dos fármacos , Linhagem Celular Tumoral , Glicosídeos/química , Humanos , Espectroscopia de Ressonância Magnética , Triterpenos/química
2.
Zhongguo Ying Yong Sheng Li Xue Za Zhi ; 34(5): 457-461, 2018 May 08.
Artigo em Chinês | MEDLINE | ID: mdl-30788929

RESUMO

OBJECTIVE: To evaluate the early cardiac injury caused by obstructive sleep apnea (OSA) before the development of cardiovascular symptoms of OSA. METHODS: Ninety-two patients without any known cardiovascular disorders who underwent polysomnography (PSG) were enrolled in the study. Subjects were divided into mild, moderate, and severe OSA groups by their apnea hypopnea index (AHI), and 25 healthy individuals were identified as controls. After PSG examination, fasting blood samples for the evaluation of N-terminal pro-brain natriuretic peptide (NT-proBNP) and heart-type fatty acid binding protein (h-FABP) were collected in the morning, and left ventricular(LV) functions were assessed by using echocardiographic methods. Thirty moderate and severe OSA patients were treated with continuous positive airway pressure respectively (CPAP). RESULTS: The levels of h-FABP and NT-proBNP were obviously higher in all OSA groups than those in the control group (P<0.01), and were positively correlated with AHI (P<0.01). The Em/Am values of all OSA groups and E/A values of the moderate and severe OSA groups were significantly reduced (P<0.01). The difference in Em/Am values among the groups was statistically significant (P<0.01). Compared with those before treatment, h-FABP and NT-BNP levels in serum of OSA patients after CPAP treatment were significantly reduced (P<0.01), and Em/Am and E/A values were significantly increased (P<0.01). CONCLUSIONS: Left ventricular diastolic dysfunction and early myocardial microtrauma are major manifestations of early heart damage in patients with OSA. CPAP therapy could significantly improve early cardiac damage in OSA patients.


Assuntos
Traumatismos Cardíacos , Apneia Obstrutiva do Sono , Disfunção Ventricular Esquerda , Pressão Positiva Contínua nas Vias Aéreas , Humanos , Polissonografia
3.
Fitoterapia ; 114: 110-114, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27593446

RESUMO

Six new caffeic acid derivatives, Clerodens E-J (1-6) were isolated from the aerial part of Clerodendranthus spicatus. Their structures were elucidated by extensive spectroscopic analysis, including NMR, MS, and ECD data. Compound 1 showed moderate antibacterial activities against drug-resistant strains of bacteria in vitro.


Assuntos
Antibacterianos/química , Ácidos Cafeicos/química , Lamiaceae/química , Antibacterianos/isolamento & purificação , Bactérias/efeitos dos fármacos , Ácidos Cafeicos/isolamento & purificação , Farmacorresistência Bacteriana , Testes de Sensibilidade Microbiana , Estrutura Molecular , Componentes Aéreos da Planta/química
4.
Shanghai Kou Qiang Yi Xue ; 23(2): 253-6, 2014 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-24935855

RESUMO

Solitary median maxillary central incisor (SMMCI) is a rare dental anomaly characterized by a symmetric central incisor of normal size, developed and erupted precisely in the midline of the maxilla in both primary and permanent dentitions. SMMCI may occur alone or be associated with other midline structures defects of the body or other systemic disorders. The best known association is holoprosencephaly (HPE). This paper reported a case of SMMCI that companied with other midline structures defects of the body.


Assuntos
Holoprosencefalia , Maxila , Anodontia , Humanos , Incisivo/anormalidades , Erupção Dentária
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