RESUMO
A new dihydrochalcone derivative, 4',6'-dihydroxy-2',4-dimethoxy-5'-(2''-hydroxybenzyl)dihydrochalcone (1) and one known dihydrochalcone, 4',6'-dihydroxy-2',4- dimethoxydihydrochalcone (2) were isolated from leaves and twigs of Cyathostemma argenteum. Their structures were established by spectral methods, mainly 2D NMR spectroscopic techniques, which involved combined applications of DEPT, COSY, HMQC and HMBC. The molecular structure of 1 was also confirmed by single crystal X-ray diffraction. The test compounds 1 and 2 displayed signiï¬cant inhibitory activity at a dose of 1 mg/ear on edema formation at all determination times, with similar intensity as phenylbutazone.
Assuntos
Annonaceae/química , Anti-Inflamatórios/química , Anti-Inflamatórios/farmacologia , Chalconas/química , Chalconas/farmacologia , Folhas de Planta/química , Animais , Anti-Inflamatórios/administração & dosagem , Chalconas/administração & dosagem , Edema/induzido quimicamente , Edema/tratamento farmacológico , Edema/metabolismo , Ligação de Hidrogênio , Masculino , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Extratos Vegetais/química , Extratos Vegetais/farmacologia , RatosRESUMO
In the title inorganic-organic hybrid compound, [Cu(2)V(4)O(12)(C(3)H(4)N(2))(8)](n), the V(V) ion is tetra-coordinated by four O atoms and the Cu(II) ion is hexa-coordinated by four N atoms from four imidazole ligands and two O atoms from two tetra-hedral vanadate (VO(4)) units in a distorted octa-hedral geometry. The structure consists of two-dimensional sheets constructed from centrosymmetric cyclic [V(4)O(12)](4-) anions covalently bound through O to [Cu(imidazole)(4)](2+) cations. Adjacent sheets are linked by N-Hâ¯O hydrogen bonds and weak C-Hâ¯π inter-actions (Hâ¯centroid distances = 2.59, 2.66, 2.76, 2.91 and 2.98â Å into a three-dimensional supra-molecular network.
