RESUMO
The nature of the polymer support plays an integral role in solid phase organic synthesis. Combinatorial and highly parallel synthetic strategies have stimulated the development of new polymer support materials with compositions and properties that allow a broader spectrum of organic transformations. Extension of solid phase organic synthesis to encoded microreactors provides an efficient methodology for preparing large numbers of discrete compounds.
Assuntos
Química Orgânica/métodos , Polímeros , Desenho de Fármacos , Estrutura Molecular , PoliestirenosRESUMO
Solid-phase organic synthesis is now a prevalent activity in drug discovery. In keeping with this keen interest is the need to develop reliable automated synthesis instrumentation as well as polymeric supports and linkers suitable for the full range of organic synthesis applications. In this paper, we review our activities in the development of new and enabling tools for automated chemical synthesis, including the following: (i) new solid supports such as ArgoGel (PS-PEG-based) and Argo-X203 (PS-based); and (ii) the Nautilus 2400 system, a fully closed and inert automated chemistry development workstation. Selected chemistry optimization and synthesis examples performed on the Nautilus and new solid supports will be described.