Hematology of Liolaemus pacha (Iguania: Liolaemidae) and its relationship with mite infestation, reproductive period and body condition.

Variations in hematological profile in reptiles can be caused by multiple factors, including parasites presence. Our goals were to identify and morphologically describe blood cells of Liolaemus pacha and analyze their relationship with sex, body condition, individual reproductive/post-reproductive period and mite infestation. Blood smear analyses do not indicate the presence of hemoparasites, suggesting that the mites Neopterygosoma do not serve as vectors for these organisms, as has been proposed for other genera of ectoparasitic mites. In post-reproductive period, there was a reduction in specimens' body condition and a higher leukocyte count in uninfected lizards. This could be a consequence of the testosterone effects, in higher concentration during the reproductive season, which can increase the metabolic rate, decreasing feeding rate. Infested and non-infested lizards showed no differences in body condition, as well as in leukocyte count, hence the host's immune system could be developing infestation tolerance. Infested specimens had a higher count of monocytes, thrombocytes, heterophils and lymphocytes. Based on cells function, mites' effect could be associated with inflammatory processes, allergic reactions or infectious diseases. These results suggested a complex interaction between lizards' hematological parameters and factors associated to ectoparasites or body conditions. We consider this work as a diagnostic tool for genus Liolaemus, to evaluate health quality, with relevance to the conservation or management of this lizard's genus.

Contributions from popular education in health to structural competency training: An experience from Chile.

Structural competency is used to train health professionals on how social, political, and economic dynamics create conditions that negatively impact a population's health. In the Global South, this approach has historical roots in social movements, popular education, social medicine, and human rights. In 1982, during a time of extreme poverty, inequality, and violence under the Chilean military dictatorship, Educación Popular en Salud (EPES), developed a programme for training community health promoters to address common illnesses and analyse the underlying causes of poor health. In 2010, EPES began using the same model to train international and Chilean health professionals. The approach advanced four competencies. Evaluations show that training contributes to transforming health professionals' mindsets and leads them to question their practices. However, educating practitioners does not change the underlying structures that generate poor health. This article examines the intersection between EPES' competencies and the structural competency framework, highlighting two major contributions of EPES to structural competency: a methodology that narrows the gap between a theoretical analysis of social determinants of health and implementing action plans; and organic long-term links with social movements that strengthen collective action in poor neighbourhoods to advance social justice.

Depression and Suicidal Behavior Comorbidity in Patients Admitted to Substance-Use Residential Treatment in Aguascalientes, Mexico.

PURPOSE: Epidemiological studies show that depressive and substance use disorders are salient risk factors for suicidal behavior. In residential centers in Mexico City, 75.72% of the patients are diagnosed with comorbidity of substance use and psychiatric disorders; however, the specific prevalence of depression and suicidal behavior in this population has not been reported. This study aims to inform the comorbidity of depression and suicidal behavior in crystal users in residential centers in the state of Aguascalientes, Mexico. METHOD: A brief survey was applied to measure substance use patterns, suicidal behavior, and depression symptoms using the Depression Scale of the Center of Epidemiological Studies (CES-D-R). The sample included 343 participants. RESULTS: The results show that of the 23.3% of participants who reported depressive symptoms, 65% showed suicidal ideation, 46% suicide planning, and 43% suicidal attempt. DISCUSSIONS: These results show the importance of implementing components that address depression and suicidal behavior in interventions for substance use. CONCLUSIONS: Currently, no specialized interventions are developed to treat substance use disorders with crystal methamphetamine and, at the same time, treat others mental problems like depression and suicidal behavior. We conclude that the development of this intervention is necessary and urgent.

Primer Consenso Chileno de Grupo de Estudio de Tuberculosis Ocular / First Chilean Consensus Document of the Ocular Tuberculosis Study Group

INTRODUCCIÓN: El tratamiento de la tuberculosis (TB) ocular es un tema que genera controversia en el mundo. Para el correcto manejo de estos pacientes, es necesario el desarrollo de guías que consideren la epidemiología de la TB ocular en cada nación. El objetivo de este consenso fue discutir de forma interdisciplinaria la epidemiología, fisiopatología, clínica, diagnóstico, estudio y tratamiento de los pacientes con TB ocular, para establecer un algoritmo de tratamiento y proponer qué pacientes deben ser tratados en Chile y con qué tratamiento. Además, se establecieron acuerdos para efectuar quimioprofilaxis de los pacientes con TB latente que tienen indicación de tratamiento inmunosupresor por enfermedades inflamatorias oculares.

The treatment of ocular tuberculosis (TB) remains controversial worldwide. The development of guidelines for ocular TB can facilitate the approach and management of these patients. These guidelines should be developed regionally, considering the local TB epidemiology. The objectives of this consensus are: to initiate an interdisciplinary discussion about the epidemiology, pathophysiology, clinical presentation, diagnosis, workup and treatment of patients with ocular TB, to establish a treatment algorithm and define which patients should be treated in Chile and how and, to analyze and discuss the published data regarding chemoprophylaxis for patients with latent TB who need to start immunosuppressive treatment due to inflammatory ocular conditions.

Conducta suicida, consumo de sustancias psicoactivas y calidad de vida en adolescentes chilenos / Suicidal behavior, psychoactive substances use and quality of life in chilean adolescents

BACKGROUND: Suicidal behavior is a public health problem, and adolescents are one of the main risk groups. Aim: To analyze the association among suicidal behavior, consumption of psychoactive substances, and Health Related Quality of Life (HRQoL) in adolescents attending schools in Valparaiso, Chile. MATERIAL AND METHODS: Five hundred-fifty adolescents enrolled in a public school participated in the study. HRQoL was evaluated through KIDSCREEN-27, while suicidal behavior and the consumption of psychoactive substances were measured with the Global School-based Student Health Survey (GSHS). RESULTS: The prevalence of suicidal behavior was higher in women and in those who used tobacco or marijuana in the last month. Respondents with a bad perception of physical well-being reported a higher frequency of suicidal ideation than those with a good perception (Odds ratio (OR): 2.24; 95% confidence: 1.49-3.36). Likewise the frequency of suicidal ideation was higher in those with a bad perception of psychological well-being (OR: 3.87; 95%CI: 2.09-7.71), and a bad perception of autonomy and relation with parents (OR:2.46; 95%CI: 1.34-4.54). Suicide planning was also associated with dimensions of autonomy and relation with parents (OR: 2.32; 95% CI: 1.23-4.38) and dimensions of friends and social support (OR: 1.86; 95%CI:1.05-3.28). Suicide attempt was associated with the dimensions of friendship and social support (OR: 1.83; 95%CI: 1.02-3.28) and school environment (OR: 1,92; 95%CI: 1,23-3,01). Conclusions: Suicide ideation is associated with worse physical and psychological well-being. Suicide planning and suicide attempt is associated with a worse perception about the relation with parents or friends, social support, and school environment.

Precocidad de inicio del consumo de sustancias psicoactivas y su relación con otros comportamientos de riesgo para la salud en adolescentes chilenos / Association between early onset of psychoactive drug use and health risk behaviors in chilean adolescents

BACKGROUND: Adolescents are more prone to develop health risk behaviors. Among these, early consumption of psychoactive drugs is relevant. AIM: To assess the association between early consumption of illicit drugs, tobacco and alcohol, suicide behaviors, risky sexual behaviors, eating habits and physical activity in school age adolescents from Valparaiso, Chile. MATERIAL AND METHODS: The online world survey of scholar health to identify the health risk behaviors was answered by 550 adolescents aged 15 to 18 years, from a public educational institution at Valparaiso, Chile. Results: Early consumption of alcohol, smoking and illicit drug use was reported by 59, 57 and 44% of respondents, respectively. The frequency of psychoactive drug consumption during the last month, risky sexual behaviors and missing breakfast was higher among those with an early onset of alcohol and illicit drug consumption and smoking. The frequency of suicidal risk behaviors and low consumption of fruits and vegetables was higher among those with an early onset of illicit drug use and smoking. A low physical activity level was associated with early smoking onset. Health risk behaviors were associated with early onset of alcohol and illicit drug consumption and smoking. CONCLUSIONS: Early onset of alcohol and illicit drug consumption and smoking is associated with health risk behaviors in Chilean adolescents.

[Suicidal behavior, psychoactive substances use and quality of life in chilean adolescents]. / Conducta suicida, consumo de sustancias psicoactivas y calidad de vida en adolescentes chilenos.

BACKGROUND: Suicidal behavior is a public health problem, and adolescents are one of the main risk groups. AIM: To analyze the association among suicidal behavior, consumption of psychoactive substances, and Health Related Quality of Life (HRQoL) in adolescents attending schools in Valparaiso, Chile. MATERIAL AND METHODS: Five hundred-fifty adolescents enrolled in a public school participated in the study. HRQoL was evaluated through KIDSCREEN-27, while suicidal behavior and the consumption of psychoactive substances were measured with the Global School-based Student Health Survey (GSHS). RESULTS: The prevalence of suicidal behavior was higher in women and in those who used tobacco or marijuana in the last month. Respondents with a bad perception of physical well-being reported a higher frequency of suicidal ideation than those with a good perception (Odds ratio (OR): 2.24; 95% confidence: 1.49-3.36). Likewise the frequency of suicidal ideation was higher in those with a bad perception of psychological well-being (OR: 3.87; 95%CI: 2.09-7.71), and a bad perception of autonomy and relation with parents (OR:2.46; 95%CI: 1.34-4.54). Suicide planning was also associated with dimensions of autonomy and relation with parents (OR: 2.32; 95% CI: 1.23-4.38) and dimensions of friends and social support (OR: 1.86; 95%CI:1.05-3.28). Suicide attempt was associated with the dimensions of friendship and social support (OR: 1.83; 95%CI: 1.02-3.28) and school environment (OR: 1,92; 95%CI: 1,23-3,01). CONCLUSIONS: Suicide ideation is associated with worse physical and psychological well-being. Suicide planning and suicide attempt is associated with a worse perception about the relation with parents or friends, social support, and school environment.

[Association between early onset of psychoactive drug use and health risk behaviors in chilean adolescents]. / Precocidad de inicio del consumo de sustancias psicoactivas y su relación con otros comportamientos de riesgo para la salud en adolescentes chilenos.

BACKGROUND: Adolescents are more prone to develop health risk behaviors. Among these, early consumption of psychoactive drugs is relevant. AIM: To assess the association between early consumption of illicit drugs, tobacco and alcohol, suicide behaviors, risky sexual behaviors, eating habits and physical activity in school age adolescents from Valparaiso, Chile. MATERIAL AND METHODS: The online world survey of scholar health to identify the health risk behaviors was answered by 550 adolescents aged 15 to 18 years, from a public educational institution at Valparaiso, Chile. RESULTS: Early consumption of alcohol, smoking and illicit drug use was reported by 59, 57 and 44% of respondents, respectively. The frequency of psychoactive drug consumption during the last month, risky sexual behaviors and missing breakfast was higher among those with an early onset of alcohol and illicit drug consumption and smoking. The frequency of suicidal risk behaviors and low consumption of fruits and vegetables was higher among those with an early onset of illicit drug use and smoking. A low physical activity level was associated with early smoking onset. Health risk behaviors were associated with early onset of alcohol and illicit drug consumption and smoking. CONCLUSIONS: Early onset of alcohol and illicit drug consumption and smoking is associated with health risk behaviors in Chilean adolescents.

Acciones metodológicas para perfeccionar la asignatura "Seguridad Nacional y Asistencia Primaria" en ciencias médicas / Methodological actions to improve the subject "National Security and Primary Assistance" in medical sciences

RESUMEN Fundamento: es necesario el perfeccionamiento de la asignatura "Seguridad Nacional y Asistencia Primaria" en 1er año de la carrera de Licenciatura en Enfermería en la que se han visto afectaciones en los resultados docentes de los alumnos, con cierta frecuencia. Objetivo: diseñar acciones metodológicas para el perfeccionamiento de la asignatura "Seguridad Nacional y Asistencia Primaria", a partir de un diagnóstico de su proceso de enseñanza. Métodos: se realizó un estudio descriptivo, transversal, con un enfoque mixto en la carrera de Licenciatura en Enfermería, con información de los cursos 2015-2016 al 2018-2019. Se emplearon métodos teóricos, empíricos y estadístico-matemáticos. Los profesores que participaron actuaron como expertos para valorar la propuesta realizada. Resultados: se constataron insuficiencias en el proceso enseñanza aprendizaje de la asignatura "Seguridad Nacional y Asistencia Primaria" en 1er año de la carrera de Licenciatura en Enfermería, que motivaron al diseño de acciones metodológicas generales y particulares en diferentes temas que contribuyen al perfeccionamiento de la asignatura. Conclusiones: las acciones metodológicas propuestas tras el diagnóstico del proceso de enseñanza de la asignatura "Seguridad Nacional y Asistencia Primaria", respetan el fondo de tiempo de la asignatura y deben tener, según los expertos, un impacto potencial previsible positivo en los estudiantes de 1er año de Licenciatura en Enfermería.

ABSTRACT Background: it is necessary to improve the subject "National Security and Primary Assistance" in the 1st year of the Nursing Bachelor's degree in which there have been affectations on the educational results of the students, with some frequency. Objective: to design methodological actions for the improvement of the subject "National Security and Primary Assistance", based on a diagnosis of the teaching process. Methods: a descriptive, cross-sectional study was carried out, with a mixed approach in the Bachelor of Nursing degree, with information from the 2015-2016 to 2018-2019 courses. Theoretical, empirical and statistical-mathematical methods were used. The professors who participated acted as experts to assess the proposal made. Results: insufficiencies were found in the teaching-learning process of the subject "National Security and Primary Care" in the 1st year of the Nursing Bachelor's degree, which motivated the design of general and particular methodological actions in different topics that contribute to the improvement of the course. Conclusions: the methodological actions proposed after the diagnosis of the teaching process of the subject "National Security and Primary Assistance", respect the amount of time devoted to the subject and according to the experts; they should have a foreseeable potential positive impact on 1st year students of the Bachelor's Degree in Nursing.

Calcitonin-Negative Neuroendocrine Carcinoma of the Thyroid Gland: Case Report and Literature Review.

Calcitonin-negative neuroendocrine tumor (CNNET) of the thyroid is an extremely rare entity. In some of the previously reported cases within the literature, the terms "atypical medullary thyroid carcinoma," "calcitonin-free oat cell carcinoma," and "a distinct clinical entity" were applied to NETs without definitive evidence of calcitonin production. In the English-language literature, not only are there only few reported cases of CNNET, but the criteria for diagnosis in these cases are also controversial. Most of the current published cases were also treated surgically for local disease. We describe a case of NET of the thyroid with calcitonin, chromogranin A and thyroglobulin negativity, synaptophysin and TTF-1 positivity, and a high Ki-67 proliferation index with metastases in the cervical region as well as mediastinal adenopathies. This case was considered an unresectable thyroid carcinoma, and chemotherapy including cisplatin and etoposide was started as neoadjuvant treatment at the department of medical oncology. Total thyroidectomy plus bilateral and central cervical dissection was performed, and the patient underwent 2 cycles of adjuvant radiotherapy. Currently, the patient's 18F-FDG-PET/CT findings show a complete response 17 months after diagnosis. In conclusion, CNNET of the thyroid is very rare and there is limited evidence regarding treatment in patients with metastases. Chemotherapy including cisplatin and etoposide as well as early aggressive surgical resection appears to positively impact patients' survival.

Hábitos alimentarios, obesidad y calidad de vida relacionada con la salud en adolescentes chilenos / Association between eating habits and health related quality of life among school age adolescents

Background: Adolescence is considered a nutritionally vulnerable period of life, since their eating habits are influenced by factors that can promote the consumption of non-nutritious food. Aim: To analyze the relation between eating habits, obesity, and the perception of Health-Related Quality of Life in school-aged adolescents. Material and Methods: A cross-sectional study of 550 adolescents aged 16 ± 1 years (60% women) attending a public education institution in Valparaíso, Chile. The Global School-based Student Health Survey (GSHS) for eating habits and the KIDSCREEN-27 survey for health-related quality of life were self-administered online. The answers were anonymous. A logistic regression analysis was conducted to evaluate the relationship between the variables, which was adjusted for age and sex. Results: Ten percent of men and 6% of women were obese. Those with an inadequate consumption of fruits had a worst perception of their physical well-being, autonomy and relationship with their parents. Psychological well-being and school environment were perceived worst among those that did not consume breakfast. Obese respondents also reported a poorest physical health. Conclusions: Inadequate eating habits and obesity have a negative effect of health-related quality of life among adolescents.

[Association between eating habits and health related quality of life among school age adolescents]. / Hábitos alimentarios, obesidad y calidad de vida relacionada con la salud en adolescentes chilenos.

BACKGROUND: Adolescence is considered a nutritionally vulnerable period of life, since their eating habits are influenced by factors that can promote the consumption of non-nutritious food. AIM: To analyze the relation between eating habits, obesity, and the perception of Health-Related Quality of Life in school-aged adolescents. MATERIAL AND METHODS: A cross-sectional study of 550 adolescents aged 16 ± 1 years (60% women) attending a public education institution in Valparaíso, Chile. The Global School-based Student Health Survey (GSHS) for eating habits and the KIDSCREEN-27 survey for health-related quality of life were self-administered online. The answers were anonymous. A logistic regression analysis was conducted to evaluate the relationship between the variables, which was adjusted for age and sex. RESULTS: Ten percent of men and 6% of women were obese. Those with an inadequate consumption of fruits had a worst perception of their physical well-being, autonomy and relationship with their parents. Psychological well-being and school environment were perceived worst among those that did not consume breakfast. Obese respondents also reported a poorest physical health. CONCLUSIONS: Inadequate eating habits and obesity have a negative effect of health-related quality of life among adolescents.

Displasia ectodérmica hipohidrótica autosómica dominante asociada a hipoparatiroidismo / Autosomal dominant hypohidrotic ectodermal dysplasia associated to hypoparathyroidism

RESUMEN Las displasias ectodérmicas constituyen alteraciones de los derivados embriológicos del ectodermo. Paciente adulta, con hipoparatiroidismo, llamó la atención por su fenotipo y fue remitida de la consulta de Neurología a la consulta Genética. Se diagnosticó una displasia ectodérmica hipohidrótica, de origen genético con herencia autosómica dominante, poco común para esta entidad. Se presenta este caso con el objetivo de describir las manifestaciones clínicas de esta alteración genética, las cuales nunca fueron objeto de interés médico resultando inadvertidas para su estudio y diagnóstico. Esta alteración se asocia a una condición patológica como el hipoparatiroidismo, en la literatura revisada no se encontraron reportes de la misma. La evaluación clínica de la paciente permitió hacer el diagnóstico y explicar muchos de los problemas para los cuales no existían respuestas, así como ofrecer un asesoramiento genético adecuado para ella y para sus familiares con riesgo de padecer una condición genética similar (AU).

ABSTRACT Ectodermic dysplasias are alterations of the ectoderm embryologic derivatives. This is a case of an adult female patient with hypoparathyroidism, drawing attention due to her phenotype; she was remitted by the consultation of Neurology to the Genetic one. She was diagnosed a hypohidrotic ectodermal dysplasia, of genetic origin with autosomal dominant inheritance, what is very rare for this entity. The case is presented with the aim of describing the clinical manifestation of this genetic alteration that never drew medical interest and nobody diagnosed or studied. It is associated to a pathologic condition like hypothyroidism and was not reported in medical literature before. The clinical evaluation of the patient allowed arriving to the diagnostic and explaining many problems that were unexplained, and also offering the adequate genetic advice to her and her relatives likewise at risk of suffering a similar genetic condition (AU).

Displasia ectodérmica hipohidrótica autosómica dominante asociada a hipoparatiroidismo / Autosomal dominant hypohidrotic ectodermal dysplasia associated to hypoparathyroidism

RESUMEN Las displasias ectodérmicas constituyen alteraciones de los derivados embriológicos del ectodermo. Paciente adulta, con hipoparatiroidismo, llamó la atención por su fenotipo y fue remitida de la consulta de Neurología a la consulta Genética. Se diagnosticó una displasia ectodérmica hipohidrótica, de origen genético con herencia autosómica dominante, poco común para esta entidad. Se presenta este caso con el objetivo de describir las manifestaciones clínicas de esta alteración genética, las cuales nunca fueron objeto de interés médico resultando inadvertidas para su estudio y diagnóstico. Esta alteración se asocia a una condición patológica como el hipoparatiroidismo, en la literatura revisada no se encontraron reportes de la misma. La evaluación clínica de la paciente permitió hacer el diagnóstico y explicar muchos de los problemas para los cuales no existían respuestas, así como ofrecer un asesoramiento genético adecuado para ella y para sus familiares con riesgo de padecer una condición genética similar.

ABSTRACT Ectodermic dysplasias are alterations of the ectoderm embryologic derivatives. This is a case of an adult female patient with hypoparathyroidism, drawing attention due to her phenotype; she was remitted by the consultation of Neurology to the Genetic one. She was diagnosed a hypohidrotic ectodermal dysplasia, of genetic origin with autosomal dominant inheritance, what is very rare for this entity. The case is presented with the aim of describing the clinical manifestation of this genetic alteration that never drew medical interest and nobody diagnosed or studied. It is associated to a pathologic condition like hypothyroidism and was not reported in medical literature before. The clinical evaluation of the patient allowed arriving to the diagnostic and explaining many problems that were unexplained, and also offering the adequate genetic advice to her and her relatives likewise at risk of suffering a similar genetic condition.

Actividad de la α-amilasa en leche materna en los primeros 50 días postparto / Activity of the α-amylase in human milk in the first 50 days postpartum

Introducción: la α-amilasa es una enzima que tiene la capacidad de digerir uniones α (1,4). En la leche sus funciones son poco conocidas. Objetivos: determinar la actividad de la α-amilasa en el suero lácteo humano. Materiales y métodos: la medición se realizó con un kit comercial para determinación de amilasa sérica y se utilizaron muestras de leche humana. Resultados: se encontró una actividad promedio de 2.000 U/l. La comparación de las medias de los valores de actividad desde el segundo al quinto día (1,372±0,796) con los correspondientes al lapso desde el sexto día al cuadragésimo séptimo (0,412±0,250) demostró que los valores eran significativamente diferentes (p<0,0025). Los coeficientes de variación de los dos grupos mencionados (1-5 días y 6-47 días) fueron 58 y 61% respectivamente. De manera adicional, la expresión de la amilasa mostró una gran variación entre madres. Conclusiones: a partir de esta información y de los antecedentes bibliográficos, la α-amilasa láctea tendría una función de defensa en el organismo del recién nacido lactante, y recién al iniciar la alimentación suplementada cumpliría el rol conocido. Aún así el significado biológico de su función en la leche es un problema abierto.

Cancer immunotherapy experience in the Integral Oncology Centre "Diana Laura Riojas de Colosio", Médica Sur Hospital.

INTRODUCTION: The useof immunotherapy in Mexico has been used since 2012 with ipilimumab and since 2015 with nivolumab and pembrolizumab, so it is a matter of necessity to know the experience of these drugs. MATERIAL AND METHODS: An observational, descriptive, cross-sectional, and retrospective study was performed in Médica Sur Hospital, where with dossiers from 2012 to June 2018 patients with metastatic cancer who received immunotherapy with ipilimumab, nivolumab, and pembrolizumab for six months were evaluated, searching as principal outcomes the adverse effects of those drugs and as secondary outcomes the response to treatment. RESULTS: Seventy subjects fulfilled the inclusion criteria for the study, and 42 (60%) were women with an average age of 60.73 ±13.64 years (16-82 years). The pathologies that received immunotherapy were the following: melanoma and lung cancer. The most frequent clinical and laboratory adverse effects were as follows: fatigue - 32 (45.71%), asthaenia - 30 (42%), nausea - 8 (11.4%), diarrhoea - 8 (11.4%), and rash - 7 (10%). The worst adverse effects were respiratory and endocrinological: pneumonitis - 10 (14.28%), hypothyroidism - 4 (5.71%), hyperglycaemia - 1 (1.4%), and hypophysitis - 2 (2.9%). With respect to treatment response: complete response - 8 (11.4%), partial response - 11 (15.71%), stable disease - 33 (47.14%), and disease progression - 19 (27.14%). CONCLUSIONS: The most common adverse effects did not condition the suspension of treatment or increase in intra-hospital stay, but there were some adverse effects that actually had an impact on evolution, hospital stay, and mortality.

Erradicación de fiebre tifoidea en Holguín. Logro de la Medicina cubana 1972-2016 / Elimination of Typhoid Fever in Holguín. An achievement of cuban Medicine. 1972-2016

Introducción: la fiebre tifoidea es una infección sistémica causada por Salmonella tiphy, a través de la ingesta de alimentos contaminados (fecal-oral). Es un problema de salud pública, especialmente en países en vías de desarrollo. Objetivo: caracterizar la fiebre tifoidea en la provincia de Holguín durante los años 1972-2016. Método: se realizó un estudio descriptivo longitudinal de series de casos reportados de fiebre tifoidea por tarjeta EDO (Enfermedades de Declaración Obligatoria) en la provincia de Holguín desde el año 1972-2016. El universo estuvo constituido por 471 pacientes reportados por fiebre tifoidea, según tarjeta de EDO. Resultados: no se reportaron fallecidos desde el año 1974 y los menores de 15 años fueron los más afectados. El municipio que se mantuvo como de alto riesgo fue Holguín. La aplicación de la vacuna cubana de polisacárido Vi, mucho menos reactogénica y más efectiva que la utilizada anteriormente de calor-fenol, puede ser la causa o parte de la causa para la no ocurrencia de casos en los últimos 10 años en la provincia. Conclusiones: la morbilidad por fiebre tifoidea ha disminuido al igual que el número de brotes y afectados en brotes. Las medidas de control inmediatas y la existencia de un programa de control, además de la nueva vacuna de producción nacional, fabricada por los laboratorios Finlay, han hecho posible tales logros.

Introduction: typhoid fever is a systemic infection caused by Salmonella tiphy through ingestion of contaminated food (fecal-oral). It is a public health problem, especially in developing country. Objective: to characterize typhoid fever in Holguin province during the years 1972-2016. Method: a longitudinal descriptive study of series of reported cases of typhoid by EDO card (Notifiable Diseases) in Holguin province since 1972 to 2016, in order to characterize the typhoid in Holguin province was conducted. The universe consisted of 471 patients reported for typhoid Fever, according to EDO card. Results: no deaths were reported since 1974, children under 15 were the most affected, the Holguin municipality remained as high risk. The application of the Vi much less reactogenic and more effective polysaccharide Cuban vaccine used previously heat-phenol, may be the cause or part of the cause for the non-occurrence of cases in the last 10 years in the province. Conclusions: the morbidity due to typhoid fever has decreased as well as the number of outbreaks and affected in outbreaks. The immediate control measures and the existence of a control program, in addition to the new vaccine of national production, manufactured by the Finlay laboratories, have made such achievements possible.

Uso de sustancias psicoactivas y calidad de vida relacionada con la salud en adolescentes escolarizados / Psychoactive substances use and health-related quality of life among school age adolescents

Background The use of psychoactive substances among adolescents is a major social and public health concern. Aim To analyze association of substance abuse and multiple drug use with health-related quality of life (HRQOL) in adolescents attending a high school in Valparaiso, Chile. Material and Methods Analytical cross-sectional study conducted in a sample of adolescents attending high school. HRQOL was assessed using KIDSCREEN-52 questionnaire and substance use was measured using the Global school-based student health survey. Participants had to complete online, self-administered, anonymous questionnaires. Multiple logistic regression analyses were conducted to calculate Odd ratios. Results A total of 550 adolescents aged 16 ± 1 years old completed the questionnaires. Thirty nine percent consumed alcohol during the last month, 31% smoked, 33% used marijuana and 33% admitted the use of multiple drugs. High-risk alcohol consumption was associated with a lower perception of psychological well-being, self-perception and school environment. This last dimension was affected in those who admitted marijuana use during the last month. Multiple drug use (three substances) was associated with a lower perception of physical and psychological well-being, self-perception, relationship with parents, family life and school environment. Conclusions High-risk alcohol consumption and multiple drug use (three substances) have a negative impact on the HRQOL of school age adolescents.

Calidad de vida en síndrome de apnea-hipopnea obstructiva del sueño (SAHOS) / Quality of life in obstructive sleep apnea-hypopnea syndrome (OSAHS)

Resumen El síndrome de apnea-hipopnea obstructiva del sueño (SAHOS) influye en la calidad de vida de las personas que lo padecen de manera diferente. Es importante medir esta repercusión, de forma objetiva, al momento de hacer el diagnóstico y durante el tratamiento, porque puede mejorar la adherencia a este último. A partir de diferentes estudios, se han creado escalas de medición generales para las enfermedades y específicas para SAHOS, las cuales permiten evaluar diferentes dimensiones como los síntomas diurnos y nocturnos, la somnolencia diurna, las emociones y la repercusión de la enfermedad sobre las interacciones sociales de las personas y la percepción del paciente frente al tratamiento establecido.

Abstract Obstructive sleep apnea-hypopnea syndrome (OSAHS) has a direct influence on the quality of life of people who suffer from it. Objectively measuring this impact at diagnosis and during treatment is important to improve the subsequent adherence to treatment. Based on different studies, general and specific disease scales for OSAHS have been created, which allow to evaluate different dimensions such as daytime symptoms, nocturnal symptoms, daytime sleepiness, emotions, the repercussion of the disease on the social interactions of people, as well as the patient's perception of the treatment indicated.

Erradicación de fiebre tifoidea en Holguín. Logro de la Medicina cubana 1972-2016 / Elimination of Typhoid Fever in Holguín. An achievement of cuban Medicine. 1972-2016

Introducción: la fiebre tifoidea es una infección sistémica causada por Salmonella tiphy, a través de la ingesta de alimentos contaminados (fecal-oral). Es un problema de salud pública, especialmente en países en vías de desarrollo.Objetivo: caracterizar la fiebre tifoidea en la provincia de Holguín durante los años 1972-2016.Método: se realizó un estudio descriptivo longitudinal de series de casos reportados de fiebre tifoidea por tarjeta EDO (Enfermedades de Declaración Obligatoria) en la provincia de Holguín desde el año 1972-2016. El universo estuvo constituido por 471 pacientes reportados por fiebre tifoidea, según tarjeta de EDO.Resultados: no se reportaron fallecidos desde el año 1974 y los menores de 15 años fueron los más afectados. El municipio que se mantuvo como de alto riesgo fue Holguín. La aplicación de la vacuna cubana de polisacárido Vi, mucho menos reactogénica y más efectiva que la utilizada anteriormente de calor-fenol, puede ser la causa o parte de la causa para la no ocurrencia de casos en los últimos 10 años en la provincia.Conclusiones: la morbilidad por fiebre tifoidea ha disminuido al igual que el número de brotes y afectados en brotes. Las medidas de control inmediatas y la existencia de un programa de control, además de la nueva vacuna de producción nacional, fabricada por los laboratorios Finlay, han hecho posible tales logros.(AU)

Introduction: typhoid fever is a systemic infection caused by Salmonella tiphy through ingestion of contaminated food (fecal-oral). It is a public health problem, especially in developing country.Objective: to characterize typhoid fever in Holguin province during the years 1972-2016.Method: a longitudinal descriptive study of series of reported cases of typhoid by EDO card (Notifiable Diseases) in Holguin province since 1972 to 2016, in order to characterize the typhoid in Holguin province was conducted. The universe consisted of 471 patients reported for typhoid Fever, according to EDO card.Results: no deaths were reported since 1974, children under 15 were the most affected, the Holguin municipality remained as high risk. The application of the Vi much less reactogenic and more effective polysaccharide Cuban vaccine used previously heat-phenol, may be the cause or part of the cause for the non-occurrence of cases in the last 10 years in the province.Conclusions: the morbidity due to typhoid fever has decreased as well as the number of outbreaks and affected in outbreaks. The immediate control measures and the existence of a control program, in addition to the new vaccine of national production, manufactured by the Finlay laboratories, have made such achievements possible.(AU)