RESUMO
BACKGROUND: Idiopathic inflammatory myopathies are a heterogeneous group of acquired muscle disorders with considerable overlap in the histological features, making histological diagnosis difficult at times. AIMS: To determine the immunohistochemical profile of clinically suspected cases of inflammatory myopathies, using monoclonal antibodies to HLA-1 and membrane attack complex (MAC), and to correlate the clinical, serological, and electromyographic profile and the histopathological picture, with the immunohistochemical profile. SETTINGS AND DESIGN: This was a retrospective study analyzing the clinical and histopathological features in muscle of clinically suspected cases of inflammatory myopathy and correlating it to their HLA-1 and MAC immunostaining profiles. MATERIAL AND METHODS: The study subjects included 33 cases with suspected inflammatory myopathy and 59 with non-inflammatory muscle disease, as controls. Clinical data, electromyographic findings, serological profile, and details of therapy were obtained from patient records. STATISTICAL ANALYSIS: Student 'T' test, Pearson's Chi square test, and Kappa statistics were used appropriately. RESULTS: Although HLA-1 and MAC immunostaining did not help to differentiate the individual subtypes of inflammatory myopathy, when either HLA-1 or MAC was positive, inflammatory myopathy could be ruled in with 86.5% certainty and when both HLA-1 and MAC were negative, it could be ruled out with 95% certainty. CONCLUSIONS: A combination of clinical presentation, serological profile, electromyographic and histopathological features, together with the immunoprofile for HLA-1 and MAC, contribute toward making a diagnosis of inflammatory myopathy.
Assuntos
Complexo de Ataque à Membrana do Sistema Complemento/metabolismo , Antígenos de Histocompatibilidade Classe I/metabolismo , Imuno-Histoquímica , Músculo Esquelético/metabolismo , Miosite/patologia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Dermatomiosite/metabolismo , Dermatomiosite/patologia , Eletromiografia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Miosite/metabolismo , Miosite/fisiopatologia , Polimiosite/metabolismo , Polimiosite/patologia , Estudos Retrospectivos , Índice de Gravidade de Doença , Adulto JovemRESUMO
In this article, we describe an unusual presentation of osteoid osteoma of the lumbar vertebra in a woman in her early 30s. Single-photon emission computed tomography/low-resolution computed tomography (SPECT/CT) fusion imaging was used to detect the osteoma, precisely localize the pathology site, and guide surgical excision of the lesion. In recent years, SPECT/CT fusion imaging has helped make interpretations of scintigraphic images significantly more accurate.
Assuntos
Vértebras Lombares/patologia , Osteoma Osteoide/diagnóstico , Neoplasias da Coluna Vertebral/diagnóstico , Tomografia Computadorizada de Emissão de Fóton Único/métodos , Tomografia Computadorizada por Raios X/métodos , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Dor Lombar/diagnóstico , Vértebras Lombares/diagnóstico por imagem , Imageamento por Ressonância Magnética , Osteoma Osteoide/cirurgia , Neoplasias da Coluna Vertebral/cirurgia , Resultado do TratamentoRESUMO
Malignant small cell neuroendocrine tumors of the pelvi-calyceal system are rare, and even more uncommon is their occurrence with concomitant transitional cell carcinoma, in the same renal unit. We present such a case for its unique presentation.
