Adenocarcinoma de próstata gigante con células en anillo de sello / Giant prostatic carcinoma with signet ring cells

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Liposarcoma de cordón espermático. A propósito de dos casos clínicos y revision de la literatura / Spermatic cord liposarcoma. Report of two cases and bibliographic review

OBJETIVO: Presentar dos casos de pacientes diagnosticados de liposarcoma paratesticular. Realizamos una revisión de la literatura de esta infrecuente entidad, con el fin de aclarar las características clínicas y terapéuticas. MÉTODOS: Revisión retrospectiva de la historia clínica de dos pacientes diagnosticados de liposarcoma del cordón espermático. Se revisó la epidemiología, diagnóstico, alternativas terapéuticas y el pronóstico. RESULTADOS: Caso 1: Varón de 65 años. Valorado por masa escrotal izquierda de gran tamaño 20 X 14 X 11 cm. Se le realiza una orquiectomía radical, siendo el resultado de la pieza un liposarcoma de cordón espermático bien diferenciado. Al año de seguimiento el paciente se encuentra asintomático y no se objetiva recidiva local. Caso 2: Varón de 90 años con antecedente de orquiectomía derecha por liposarcoma de cordón bien diferenciado hace 11 años, y excéresis de recidiva hace 7 años. En el seguimiento presenta una nueva recidiva tumoral a nivel inguinal, de 20 X 14 X 11 cm. Se realiza una exéresis de la masa la cual se informa como liposarcoma de cordón espermático bien diferenciado. A los 10 meses, tras la cirugía, el paciente se encuentra asintomático y sin recidiva. CONCLUSIONES: El liposarcoma es un tumor muy infrecuente y su diagnóstico se realiza anatomopatológicamente, lo que dificulta establecer pautas de tratamiento, pronóstico y diagnóstico diferencial. Al igual que en los liposarcomas de otras localizaciones es de valor pronóstico el tipo y grado histológico del tumor. La orquiectomía radical inguinal y la resección del tumor con márgenes microscópicos negativos es el tratamiento recomendado. No se ha demostrado la eficacia de tratamientos adyuvantes como la quimioterapia o radioterapia, salvo en situaciones concretas. La historia natural de la enfermedad es lenta y con escasa mortalidad, pero con una alta tasa de recidiva, por lo que un seguimiento a largo plazo es necesario

OBJECTIVE: We report two cases of patients diagnosed of paratesticular liposarcoma and perform a literature review of this rare entity. Our aim is to clarify its clinical and therapeutic characteristics. METHODS: Retrospective review of the medical records of two patients diagnosed of liposarcoma of the spermatic cord. RESULTS: Case 1: 65 year old male, presented a left large scrotal mass of 20 X 14 X 11 cm. He underwent radical orchiectomy. Pathology reported a well differentiated spermatic cord liposarcoma. After one year of follow-up the patient was asymptomatic and there was no evidence of local recurrence. Case 2: A 90 year old man, with past medical history of right orchiectomy for well-differentiated cord liposarcoma 11 years before, and excision of recurrence 7 years ago. On follow up he presented a new 20 X 14 X 11 cm inguinal tumor recurrence. We performed excision of the mass, which was reported by pathology as well differentiated spermatic cord liposarcoma. Ten months after surgery the patient was asymptomatic without recurrence. CONCLUSIONS: Liposarcoma is a very rare entity and its diagnosis is based on the pathological findings. It is therefore difficult to establish the guidelines for treatment, prognosis and differential diagnosis. As in liposarcomas in other sites, the histological type and grade of the lesion are useful for the prognosis. Radical inguinal archiectomy and resection of the tumor with a negative microscopic margin is the recommended treatment for liposarcoma of the spermatic cord. It has not been demonstrated the efficacy of adjuvant treatments such as chemotherapy or radiotherapy, except in specific situations. The natural history of disease is slow and it has low mortality, but high recurrence rate, so a long-term monitoring is necessary

[Spermatic cord liposarcoma. Report of two cases and bibliographic review.] / Liposarcoma de cordón espermático. A propósito de dos casos clínicos y revision de la literatura.

OBJECTIVE: We report two cases of patients diagnosed of paratesticular liposarcoma and perform a literature review of this rare entity. Our aim is to clarify its clinical and therapeutic characteristics. METHODS: Retrospective review of the medical records of two patients diagnosed of liposarcoma of the spermatic cord. RESULTS: Case 1: 65 year old male, presented a left large scrotal mass of 20 × 14 × 11 cm. He underwent radical orchiectomy. Pathology reported a well differentiated spermatic cord liposarcoma. After one year of follow-up the patient was asymptomatic and there was no evidence of local recurrence. Case 2: A 90 year old man, with past medical history of right orchiectomy for well-differentiated cord liposarcoma 11 years before, and excision of recurrence 7 years ago. On follow up he presented a new 20 × 14 × 11 cm inguinal tumor recurrence. We performed excision of the mass, which was reported by pathology as well differentiated spermatic cord liposarcoma. Ten months after surgery the patient was asymptomatic without recurrence. CONCLUSIONS: Liposarcoma is a very rare entity and its diagnosis is based on the pathological findings. It is therefore difficult to establish the guidelines for treatment, prognosis and differential diagnosis. As in liposarcomas in other sites, the histological type and grade of the lesion are useful for the prognosis. Radical inguinal orchiectomy and resection of the tumor with a negative microscopic margin is the recommended treatment for liposarcoma of the spermatic cord. It has not been demonstrated the efficacy of adjuvant treatments such as chemotherapy or radiotherapy, except in specific situations. The natural history of disease is slow and it has low mortality, but high recurrence rate, so a long-term monitoring is necessary.

[Evolution of the clinical presentation of renal cancer. Fifteen years experience]. / Evolución de las manifestaciones clínicas del cáncer renal. Experiencia de 15 años.

OBJECTIVE: To evaluate the evolution of the clinical presentation of this malignancy over time, and its possible prognostic repercussions. METHODS: A retrospective study of 538 patients subjected to surgery due to renal cancer in our hospital during the period 1995-2011. An analysis was made of the evolution of the clinical manifestations at the time of diagnosis, stratifying the results by years during four time periods. RESULTS: At the time of diagnosis, 53,4% of the patients were asymptomatic for 1995-1999 and 72% in the period 2008-2011. Pain is the symptom that occurs most frequently (18.8%) followed by hematuria (15.4% ). The proportion of symptomatic patients increases in relation to stage and histopathological grade. CONCLUSIONS: The clinical presentation of renal cancer has evolved over the years, not in terms of symptoms, which when present are still similar, but in terms of their incidence.

Evolución de las manifestaciones clínicas del cáncer renal. Experiencia de 15 años / Evolution of the clinical presentation of renal cancer: Fifteen years experience

OBJETIVO: Análisis del cambio de presentación clínica del tumor renal con el paso del tiempo y su posible repercusión pronóstica. MÉTODOS: Estudio retrospectivo de 538 pacientes intervenidos quirúrgicamente por esta patológica en nuestro hospital entre 1995 y 2011. Analizamos la evolución de las manifestaciones clínicas al diagnóstico estratificando los resultados por años divididos en cuatro periodos. RESULTADOS: Se observa un porcentaje significativamente creciente de diagnóstico en pacientes asintomáticos con el paso del tiempo siendo del 53.4% en el periodo 1995-1999 y del 72 % en 2008-2011. El dolor es el síntoma que se presenta con mayor frecuencia (18.8%) seguido de la hematuria (15.4%). El porcentaje de pacientes sintomáticos aumenta con el estadio y el grado tumoral. CONCLUSIÓN: Las manifestaciones clínicas del tumor renal han evolucionado con el tiempo, no en cuanto a los síntomas que cuando están presentes son similares, sino en cuanto a su incidencia (AU)

OBJECTIVE: To evaluate the evolution of the clinical presentation of this malignancy over time, and its possible prognostic repercussions. METHODS: A retrospective study of 538 patients subjected to surgery due to renal cancer in our hospital during the period 1995-2011. An analysis was made of the evolution of the clinical manifestations at the time of diagnosis, stratifying the results by years during four time periods. RESULTS: At the time of diagnosis, 53,4% of the patients were asymptomatic for 1995-1999 and 72% in the period 2008-2011. Pain is the symptom that occurs most frequently (18.8%) followed by hematuria (15.4%). The proportion of symptomatic patients increases in relation to stage and histopathological grade. CONCLUSIONS: The clinical presentation of renal cancer has evolved over the years, not in terms of symptoms, which when present are still similar, but in terms of their incidence (AU)