COVID-19 Secondary Infections in ICU Patients and Prevention Control Measures: A Preliminary Prospective Multicenter Study.

The incidence of secondary infections in critically ill coronavirus disease 2019 (COVID-19) patients is worrisome. We investigated whether selective digestive decontamination (SDD) added to infection control measures during an intensive care unit (ICU) stay modified these infection rates. Methods: A retrospective observational cohort study was carried out in four ICUs in Spain. All consecutive ventilated patients with a SARS-CoV-2 infection engaged in national infection control programs between 1 March and 10 December 2020 were investigated. Patients were grouped into two cohorts according to the site of ICU admission. Secondary relevant infections were included. Infection densities corresponding to ventilator-associated pneumonia (VAP), catheter bacteremia, secondary bacteremia, and multi-resistant germs were obtained as the number of events per 1000 days of exposure and were compared between SDD and non-SDD groups using Poisson regression. Factors that had an independent association with mortality were identified using multidimensional logistic analysis. Results: There were 108 patients in the SDD cohort and 157 in the non-SDD cohort. Patients in the SDD cohort showed significantly lower rates (p < 0.001) of VAP (1.9 vs. 9.3 events per 1000 ventilation days) and MDR infections (0.57 vs. 2.28 events per 1000 ICU days) and a non-significant reduction in secondary bacteremia (0.6 vs. 1.41 events per 1000 ICU days) compared with those in the non-SDD cohort. Infections caused by MDR pathogens occurred in 5 patients in the SDD cohort and 21 patients in the non-SDD cohort (p = 0.006). Differences in mortality according to SDD were not found. Conclusion: The implementation of SDD in infection control programs significantly reduced the incidence of VAP and MDR infections in critically ill SARS-CoV-2 infected patients.

Shock Index asociado a la edad y al Glasgow Coma Score como predictor de mortalidad en la atención inicial del paciente politraumatizado / Shock index combined with age and the Glasgow Coma Scale during the initial care of polytraumatized patients as a predictor of mortality

Objetivo: Estudiar si la edad y la puntuación Glasgow Coma Score (GCS) incrementan la predicción de mortalidad del Shock Index (SI) en la atención inicial del paciente politraumatizado y compararlo con las escalas pronósticas, GAP (Glasgow Coma Score-Age-Systolic Blood Pressure), RTS (Revised Trauma Score) e ISS (Injury Severity Score). Método: Estudio observacional sobre una cohorte de pacientes de la unidad de cuidados críticos de un hospital de tercer nivel con diagnóstico de trauma grave entre 2015 y 2020. Se recogió el SI (FC/TAS) y el SI asociado al GCS (SI/G), a la edad (SIA) y a ambos (SIA/G). Se calculó el área bajo la curva (ABC) de la característica operativa del receptor (COR) para cada uno de ellos para la mortalidad hospitalaria (MH) y en las primeras 24 horas (M24). También se comparó el ABC COR del SIA/G con las de las escalas GAP, RTS e ISS. Resultados: Se analizaron 433 pacientes de los cuales fallecieron 47 (10,9%). Todos los SI se relacionaron significativamente con la mortalidad, pero el SIA/G presentó la mayor ABC COR para MH (0,879, IC95% 0,83-0,93) y para M24 (0,875, IC95% 0,82-0,93). El valor SIA/G de 3,3 puntos mostró una sensibilidad del 82% y especificidad del 80% para MH y del 86% y 78% para M24. El ABC COR del SIA/G para la MH fue superior a las de las escalas GAP, RTS e ISS. Conclusión. SIA/G es superior al SI y a las escalas clásicas GAP, RTS e ISS como predictor de MH del paciente politraumatizado. (AU)

Objectives: To study whether combining age and the Glasgow Coma Scale (GCS) with the shock index (SI) - SIA/G - during the initial care of polytraumatized patients can improve the ability of the SI alone to predict mortality. To compare the predictive performance of the SIA/G combination to other prognostic scales: the addition of points for the GCS, age and systolic blood pressure (GAP); the Revised Trauma Score (RTS); and the Injury Severity Score (ISS). Material and methods: Observational cohort study of patients with severe trauma admitted to the intensive care unit of a tertiary care hospital between 2015 and 2020. We calculated the SI (heart rate/systolic blood pressure), the SI/G ratio, the product of the SI and age SIA, and the combined index: SIA/G. The areas under the receiver operating characteristic curves (AUROCs) for hospital mortality and 24-hour mortality were calculated for the SIA/G combination and compared to the AUROCs for the GAP, the RTS, and the ISS. Results: We analyzed data for 433 patients, 47 of whom (10.9%) died. All the prognostic indexes were significantly related to mortality but the SIA/G was the best predictor of both hospital and 24-hour mortality, with AUROCs of 0.879 (95% CI, 0.83-0.93) and 0.875 (95% CI, 0.82-0.93), respectively. A score of 3.3 for the SIA/G showed 82% sensitivity and 80% specificity for hospital mortality (86% and 78%, respectively, for 24-hour mortality). The AUROCs for the GAP, RTS, and ISS indexes were lower for hospital mortality. Conclusion: The combined SIA/G score is a better predictor in hospital of mortality in patients with multiple injuries than the SI or the traditional GAP, RTS, and ISS indexes.

Shock index combined with age and the Glasgow Coma Scale during the initial care of polytraumatized patients as a predictor of mortality. / Shock Index asociado a la edad y al Glasgow Coma Score como predictor de mortalidad en la atención inicial del paciente politraumatizado.

OBJECTIVES: To study whether combining age and the Glasgow Coma Scale (GCS) with the shock index (SI) - SIA/G - during the initial care of polytraumatized patients can improve the ability of the SI alone to predict mortality. To compare the predictive performance of the SIA/G combination to other prognostic scales: the addition of points for the GCS, age and systolic blood pressure (GAP); the Revised Trauma Score (RTS); and the Injury Severity Score (ISS). MATERIAL AND METHODS: Observational cohort study of patients with severe trauma admitted to the intensive care unit of a tertiary care hospital between 2015 and 2020. We calculated the SI (heart rate/systolic blood pressure), the SI/G ratio, the product of the SI and age SIA, and the combined index: SIA/G. The areas under the receiver operating characteristic curves (AUROCs) for hospital mortality and 24-hour mortality were calculated for the SIA/G combination and compared to the AUROCs for the GAP, the RTS, and the ISS. RESULTS: We analyzed data for 433 patients, 47 of whom (10.9%) died. All the prognostic indexes were significantly related to mortality but the SIA/G was the best predictor of both hospital and 24-hour mortality, with AUROCs of 0.879 (95% CI, 0.83-0.93) and 0.875 (95% CI, 0.82-0.93), respectively. A score of 3.3 for the SIA/G showed 82% sensitivity and 80% specificity for hospital mortality (86% and 78%, respectively, for 24-hour mortality). The AUROCs for the GAP, RTS, and ISS indexes were lower for hospital mortality. CONCLUSION: The combined SIA/G score is a better predictor in hospital of mortality in patients with multiple injuries than the SI or the traditional GAP, RTS, and ISS indexes.

OBJETIVO: Estudiar si la edad y la puntuación Glasgow Coma Score (GCS) incrementan la predicción de mortalidad del Shock Index (SI) en la atención inicial del paciente politraumatizado y compararlo con las escalas pronósticas, GAP (Glasgow Coma Score-Age-Systolic Blood Pressure), RTS (Revised Trauma Score) e ISS (Injury Severity Score). METODO: Estudio observacional sobre una cohorte de pacientes de la unidad de cuidados críticos de un hospital de tercer nivel con diagnóstico de trauma grave entre 2015 y 2020. Se recogió el SI (FC/TAS) y el SI asociado al GCS (SI/G), a la edad (SIA) y a ambos (SIA/G). Se calculó el área bajo la curva (ABC) de la característica operativa del receptor (COR) para cada uno de ellos para la mortalidad hospitalaria (MH) y en las primeras 24 horas (M24). También se comparó el ABC COR del SIA/G con las de las escalas GAP, RTS e ISS. RESULTADOS: Se analizaron 433 pacientes de los cuales fallecieron 47 (10,9%). Todos los SI se relacionaron significativamente con la mortalidad, pero el SIA/G presentó la mayor ABC COR para MH (0,879, IC 95% 0,83-0,93) y para M24 (0,875, IC 95% 0,82-0,93). El valor SIA/G de 3,3 puntos mostró una sensibilidad del 82% y especificidad del 80% para MH y del 86% y 78% para M24. El ABC COR del SIA/G para la MH fue superior a las de las escalas GAP, RTS e ISS. CONCLUSIONES: SIA/G es superior al SI y a las escalas clásicas GAP, RTS e ISS como predictor de MH del paciente politraumatizado.