Case report: Efficacy of immunotherapy as conversion therapy in dMMR/MSI-H colorectal cancer: a case series and review of the literature.

Immunotherapy has demonstrated a role in the therapeutic landscape of a small subset of patients with colorectal carcinoma (CRC) that harbor a microsatellite instability (MSI-H) status due to a deficient DNA mismatch repair (dMMR) system. The remarkable responses to immune checkpoint inhibitors (ICIs) are now being tested in the neoadjuvant setting in localized CRC, where the dMMR/MSI-H status can be found in up to 15% of patients, with remarkable results obtained in NICHE2 and 3 trials, among others. This case series aims to report our experience at a tertiary center and provide a comprehensive analysis of the possible questions and challenges to overcome if ICIs were established as standard of care in a neoadjuvant setting, as well as the potential role they may have as conversion therapy not only in locoregional advanced CRC but also in oligometastatic disease.

Localized Colonic Small-Cell Carcinoma with Pathological Complete Response after Neoadjuvant Cisplatin and Etoposide: A Case Report.

Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). It is a high-grade and poorly differentiated neuroendocrine tumor, usually diagnosed in advanced stages, with a poor prognosis and few therapeutic options in that setting. This is a case report of a 77-year-old Spanish male patient with localized SCC of the colon, who presented a pathological complete response in the surgical specimen after neoadjuvant chemotherapy with cisplatin and etoposide. To date, 5 years after surgery, the patient remains without evidence of tumor recurrence. As clinical guidelines for the management of this entity are lacking, and therefore its management has not been standardized, an attempt to summarize the current evidence in the literature was made.

Six-month safety follow-up of an adjuvanted SARS-CoV-2 trimeric S-protein subunit vaccine (SCB-2019) in adults: A phase 2/3, double-blind, randomized study.

BACKGROUND: We evaluated the safety of SCB-2019, a protein subunit vaccine candidate containing a recombinant SARS-CoV-2 spike (S) trimer fusion protein, combined with CpG-1018/alum adjuvants. METHODS: This ongoing phase 2/3, double-blind, placebo-controlled, randomized trial is being conducted in Belgium, Brazil, Colombia, the Philippines, and South Africa in participants ≥ 12 years of age. Participants were randomly assigned to receive 2 doses of SCB-2019 or placebo administered intramuscularly 21 days apart. Here, we present the safety results of SCB-2019 over the 6-month period following 2-dose primary vaccination series in all adult participants (≥18 years of age). RESULTS: A total of 30,137 adult participants received at least one dose of study vaccine (n = 15,070) or placebo (n = 15,067) between 24 March 2021 and 01 December 2021. Unsolicited adverse events, medically-attended adverse events, adverse events of special interest, and serious adverse events were reported in similar frequencies in both study arms over the 6-month follow-up period. Vaccine-related SAEs were reported by 4 of 15,070 SCB-2019 recipients (hypersensitivity reactions in two participants, Bell's palsy, and spontaneous abortion) and 2 of 15,067 placebo recipients (COVID-19, pneumonia, and acute respiratory distress syndrome in one participant and spontaneous abortion in the other one). No signs of vaccine-associated enhanced disease were observed. CONCLUSIONS: SCB-2019 administered as a 2-dose series has an acceptable safety profile. No safety concerns were identified during the 6-month follow-up after the primary vaccination. CLINICAL TRIALS REGISTRATION: NCT04672395; EudraCT: 2020-004272-17.

10Vida: A Mental and Physical Health Intervention for Chronically Ill Adolescents and Their Caregivers in the Hospital Setting: An Open Study.

Suffering from a chronic disease (CD) in adolescence can significantly impact the emotional health of adolescents and their families. MHealth can be a useful tool for these groups. However, few intervention programmes include the family system. The aim is to design an intervention programme (10Vida) for a paediatric population with a CD, and their families, to improve their adaptation to the disease. The study is a quasi-experimental repeated measures design in a open study, where the patients themselves, and their families, are their own control group. Participants will receive an intervention of seven individual sessions: five sessions with each patient, and two sessions with their caregivers. In the case of the patients, the aim is to improve their emotional state, their self-esteem, and their emotional competencies, reducing their perceived threat of illness. Furthermore, in the case of the caregivers, the aim is to improve their emotional state and reduce their burden. Indirectly, working with caregivers and those being cared for will improve family ties. The pilot study will involve 25 to 30 chronically ill adolescents aged between 12 and 16 years and their primary caregivers. Following the results, the necessary modifications will be included, and the programme will be offered to adolescents and their families who are willing to participate.

Impact after 10-year use of pneumococcal conjugate vaccine in the Brazilian national immunization program: an updated systematic literature review from 2015 to 2020.

In 2010, a 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) was introduced in the Brazilian national immunization program; the 3 + 1 dose schedule was replaced by a 2 + 1 dose schedule in 2016. This systematic review presents the latest published evidence (2015-2020) on the impact after 10-year use of PHiD-CV in Brazil from a total of 29 publications. Overall, the PHiD-CV program had a positive impact on the morbidity and mortality associated with invasive pneumococcal disease (IPD), pneumonia and acute otitis media (AOM) in children <5 years-old. A reduction in the vaccine-type invasive disease was observed in all-ages; suggesting indirect protection unvaccinated older children and adults. The occurrence of non-vaccine type disease was evidenced in some studies. Higher vaccination coverage is required at national and state level for sustained population impact. Given the change in the vaccination schedule and the dynamics of pneumococcal disease epidemiology, continuous surveillance is warranted.GSK Study identifier: HO-18-19438.

Epilepsy, status epilepticus, and hemiplegic migraine coexisting with a novel SLC4A4 mutation.

BACKGROUND: Recessive mutations in the SLC4A4 gene cause a syndrome characterised by proximal renal tubular acidosis (pRTA), mental retardation, dental and ocular abnormalities, and hemiplegic migraine. Rare cases involving the development of epilepsy or its severe complication-status epilepticus-have been described. METHODS: The clinical and genetic status of four affected members in a Spanish family was studied. The SLC4A4 gene mutation was detected with a next-generation sequencing (NGS) panel in the proband, and Sanger confirmed the putative mutations in affected relatives. In silico analysis was performed to elucidate the putative effect of mutation on the splicing process. RESULTS: A novel mutation, c.2562+2T>G, was identified in the homozygous state in all diseased members of the family. This mutation affected a canonical splice site and is predicted to abolish the wild-type donor site, which predicts a premature truncated NBCe1 protein with cotransport activity. The resulting protein lacks the 190 amino acids of the carboxyl-terminus, and the effect is likely to be a loss of function. All patients suffered from severe pRTA and ocular abnormalities, and the adults also suffered from neurological complications, such as hemiplegic migraine and/or epilepsy. Two developed life-threatening status epilepticus, although they fully recovered and remained free of seizures with valproate. CONCLUSION: These results expand the clinical and mutational spectra of SLC4A4-related disease and have implications for understanding the potential role of NBCe1 in the pathophysiologic processes of hemiplegic migraine and epilepsy/status epilepticus associated with the mutation.

Corneal graft surgery: A monocentric long-term analysis.

PURPOSE: To investigate indications, outcomes and changes in clinical patterns of keratoplasty surgery in a Spanish tertiary eye center. SETTING: Vissum Instituto Oftalmológico, Alicante, Spain. METHODS: A retrospective review was performed on clinical records of patients that underwent any kind of corneal transplant from 2001 to 2017 in the study center. Inclusion criteria involved the presence of detailed preoperative examination, surgical report and at least 12 months follow-up after the surgery. A statistical analysis was performed on the indications for keratoplasty, survival rates, type of graft failures, and visual outcomes. RESULTS: A total of 907 keratoplasties procedures were identified. About 432 penetrating keratoplasty (PK), 148 deep anterior lamellar keratoplasty (DALK), and 134 endothelial keratoplasty (EK) met the inclusion criteria. Cumulative survival rate ranged from 94% to 69% in a 1-year period and from 85% to 45% in a 5-years period according to the different graft types. The main cause for failure was immunological rejection for PK, surface diseases for DALK and primary graft failure for EK. Postoperative visual function improved for all the surgical techniques. CONCLUSION: Corneal transplant is a challenging surgery still complicated by a relevant risk of failure. Our study offers a useful opinion of the current trends on keratoplasty in our country, where the outcomes of the grafts differ considerably in relation to the indications and the different surgical techniques, with lamellar procedures that showed higher rates of success and better visual outcomes than full-thickness grafts.

Factores relacionados con la adherencia a tratamientos de larga duración en adolescentes: Estudio descriptivo en un hospital terciario / Factors related to adherence to long-term treatment in adolescents. descriptive study in a tertiary hospital

Objetivo: Identificar los factores que pueden condicionar la adherencia a tratamientos de larga duración en adolescentes. Método: Estudio observacional, descriptivo y transversal realizado en el Campus Hospitalario Vall d'Hebron de Barcelona. Los participantes fueron adolescentes entre 12 y 18 años, con las siguientes condiciones: trasplantados de órganos sólidos, enfermedad oncohematológica, diabetes tipo 1, fibrosis quística o VIH+; así como sus cuidadores. Resultados: Participaron 153 adolescentes y 153 cuidadores. La media de edad de los adolescentes fue de 15 años (DE = 2) y el 54 % (83) eran varones. El 69 % (106) de los cuidadores eran mujeres. El 49 % (75) refirió saltarse el tratamiento alguna vez al mes o más frecuentemente; de ellos, el 92 % (69) conocía las consecuencias de no cumplirlo. Los diabéticos fueron el grupo que refirieron incumplimiento frecuente en menor porcentaje (25.6 %). Las causas principales de incumplimiento fueron el olvido (64 %), no disponer de la medicación (19 %) o cansarse de tomarla (11 %). El 39 % (59) de los cuidadores afirmaron que existían problemas de aceptación y cumplimiento por parte del adolescente. Se halló una mayor frecuencia de incumplimiento en pacientes con mayor número de fármacos y vías de administración. Las mujeres refirieron una mayor participación en las visitas de seguimiento. Conclusiones: Las variables asociadas a complejidad del tratamiento se relacionaron con incumplimiento frecuente. No hubo diferencias entre patologías en cuanto a las causas de incumplimiento referidas, hecho que podría facilitar el diseño de intervenciones transversales en cronicidad pediátrica. Las diferencias halladas entre sexos sugieren un estilo más participativo entre las adolescentes

Objetives: To identify the factors that can condition adherence to long-term treatment in adolescents. Method: An observational, descriptive and cross-sectional study carried out at the Vall d'Hebron Hospital Campus. Participants were adolescents between 12 and 18 years of age, with the following conditions: solid organ transplants, oncohematologic disease, type 1 diabetes, cystic fibrosis or HIV+ and their caregivers. Results: 153 adolescents and 153 caregivers participated. The mean age of adolescents was 15 years (SD = 2) and 54 % (83) were boys. 69 % (106) of the caregivers were women. 49 % (75) reported that they skipped treatment once a month or more frequently, of whom 92 % (69) knew the consequences of not doing so. Diabetics were the group that reported frequent noncompliance in a lower percentage (25.6 %). The main causes of noncompliance were forgetfulness (64 %), not having medication (19 %) or getting tired of taking it (11 %). 39 % (59) of the caregivers affirmed that there were problems of acceptance and compliance of the treatment by the adolescent. A higher frequency of noncompliance was found in patients with higher numbers of drugs and routes of administration. Women reported increased participation in follow-up visits. Conclusions: Variables associated with the complexity of treatment were related to frequent non-compliance. There were no differences between pathologies regarding the causes of noncompliance referred, which could facilitate the design of global interventions in pediatric chronicity. Differences found between sexes suggest a more participatory style and greater responsibility among women

Efecto reductor del colesterol de una combinación de levadura roja de arroz y policosanol / Efeito de reduçao do colesterol de uma combinaçao de arroz vermelho fermentado e policosanol / Cholesterol lowering effect of a combination of red yeast rice and polycosanol

Es ampliamente conocido que los niveles altos de colesterol están relacionados con el riesgo cardiovascular. La levadura de arroz rojo o levadura roja de arroz es un producto obtenido a partir de una levadura (Monascus purpureus Went.), que crece sobre este cereal. Entre sus componentes destaca la monacolina K, también conocida como lovastatina, sustancia relacionada con la disminución del colesterol mediante la inhibición de la HMG-CoA reductasa. El policosanol, mezcla de alcoholes alifáticos, obtenido de la caña de azúcar (Saccharum officinarum L.), además de modular dicha enzima, aumenta la actividad de los receptores LDL y tiene un efecto antioxidante y antiagregante. Mediante este trabajo se aportan los resultados de 65 pacientes en los cuales se ha observado una disminución media, estadísticamente significativa, de los niveles de colesterol (22% del colesterol total y 29% del LDL) y una disminución del 22% de los triglicéridos, tras tomar durante 2 meses un producto compuesto por: levadura roja de arroz con un contenido diario de 10 mg monacolina K y 14 mg de policosanol extraído de la caña de azúcar. La combinación de la monacolina K y el policosanol se plantean como una opción en pacientes con riesgo cardiovascular bajo o moderado (AU)

É amplamente conhecido que os níveis elevados de colesterol estão associados a um risco acrescido de doença cardiovascular. O arroz vermelho fermentado (ou levedura de arroz vermelho) é um produto obtido a partir de uma levedura (Monascus purpureus Went.), que cresce no arroz. Entre os seus componentes destaca-se a monacolina K, também conhecida como lovastatina, substância relacionada com a redução do colesterol através da inibição da HMG-CoA redutase. O policosanol, que consiste numa mistura de álcoois alifáticos de cadeia longa obtida a partir da cana-de-açúcar (Saccharum officinarum L.), além de modular a mesma enzima (HMG-CoA redutase), aumenta a actividade de receptores de LDL e tem efeitos antioxidantes e antiagregantes plaquetários. Este trabalho reporta os resultados de 65 participantes nos quais se observou uma diminuição média estatisticamente significativa do valor de colesterol (22% do colesterol total e 29% do LDL), assim como uma diminuição de 22% do valor dos triglicéridos, após a toma, durante dois meses, de um produto composto por arroz vermelho fermentado e policosanol, correspondendo a uma toma diária de 10 mg de monacolina K e 14 mg de policosanol. Assim, a associação de monacolina K, e policosanol apresenta-se como uma opção para doentes com risco cardiovascular baixo ou moderado (AU)

It is widely known that high cholesterol levels are associated with cardiovascular risk. Red yeast rice or red rice yeast is a product obtained from a yeast (Monascus purpureus Went.), which grows on rice. Among its constituents, it stand out monacolin K, also known as lovastatin, compound related to the cholesterol lowering effect through the inhibition of the HMG-CoA reductase. Polycosanol is a mixture of long chain aliphatic alcohols obtained from sugar cane (Saccharum officinarum L.). In addition of modulating that enzyme, it increases the activity of LDL receptors and has antioxidant and antiplatelet effect. In the present work, results in 65 patients treated for 2 mounts with a product combining red yeast rice (providing 10 mg/day of monacolin K) and policosanol from sugar cane (14 mg/day). An average decrease, statistically significant, of blood cholesterol (22% of total cholesterol and 29% of LDL) and triglycerides (22% ) has been observed. The combination of monacolin K and polycosanol is considered an option for patients with low or moderate cardiovascular risk (AU)

Opinión de los profesionales sanitarios sobre la adherencia y manejo de tratamientos de larga duración en adolescentes / Opinion of health professionals on adherence and management of long-term treatments in adolescents

Objetivo. Conocer la opinión de los profesionales sanitarios sobre la adherencia y el manejo de tratamientos de larga duración en adolescentes en un hospital de tercer nivel. Método. Estudio observacional, descriptivo y transversal, realizado en el Hospital Universitari Vall d'Hebron de Barcelona, España. Los sujetos de estudio fueron los profesionales sanitarios que atienden a los adolescentes trasplantados de órganos sólidos, seropositivos, con enfermedad oncohematológica, diabetes o fibrosis quística. La recogida de datos se realizó mediante cuestionario autocumplimentado, elaborado específicamente para este estudio. Resultados. Participaron 105 profesionales (70 %). Un 80 % eran enfermeras. El 56 % consideró que el cumplimiento del tratamiento de los adolescentes era bueno. Un 43 % señaló que la adherencia no se abordaba bien. El 79 % de los profesionales no disponían de tiempo planificado para realizar educación sanitaria relacionada con el tratamiento. El 19.5 % de las enfermeras y el 72,2 % de los médicos indicaron disponer de instrumentos de evaluación de la adherencia. El 39 % de los participantes realizó propuestas de mejora. Conclusiones. Casi la mitad de los profesionales opina que la adherencia terapéutica no se aborda adecuadamente. Es importante la evaluación de la adherencia a los tratamientos para identificar causas de bajo cumplimiento e instaurar y evaluar intervenciones adecuadas (AU)

Objective. To assess opinion of health professionals about adherence and management of long-term treatments in adolescents in a tertiary hospital. Method. A cross-sectional study was carried out in the Vall d'Hebron University Hospital in Barcelona, Spain. Participants were health professionals who care adolescents with solid organ transplant, hematologic disease, diabetes, cystic fibrosis or HIV+. Data collection was performed by self-administered questionnaire, developed specifically for this study. Results. A total of 105 professionals (70 %) participated in the study, 80 % were nurses, 56 % of them indicated that treatment compliance was good. 43 % indicated that adherence was not addressed well and 79 % of professionals did not have planned time to conduct health education related to treatment. 19.5 % of nurses and 72.2 % of physicians reported having adherence assessment tools. 39 % of participants made ??suggestions for improvement. Conclusions. Almost half of the professional indicate that the adherence is not adequately addressed. It is important to evaluate adherence to treatment to identify causes of low compliance and establish and evaluate appropriate interventions (AU)

Infección por virus de la hepatitis C, interferón alfa y lupus, una curiosa asociación / Hepatitis C virus infection, interferon alpha and lupus; a curious combination

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Impact of isolated hepatitis C virus (HCV) core-specific antibody detection and viral RNA amplification among HCV-seronegative dialysis patients at risk for infection.

Amplification of hepatitis C virus (HCV) RNA from blood detected occult HCV infections in 30.9% of 210 HCV-seronegative dialysis patients with abnormal liver enzyme levels that had evaded standard HCV testing practices. Isolated HCV core-specific antibody detection identified three additional anti-HCV screening-negative patients lacking HCV RNA amplification in blood who were considered potentially infectious. Together, these findings may affect management of the dialysis setting.

[OPINION OF HEALTH PROFESSIONALS ON ADHERENCE AND MANAGEMENT OF LONG-TERM TREATMENTS IN ADOLESCENTS]. / Opinión de los profesionales sanitarios sobre a adherencia y manejo de tratamientos de larga duración en adolescents.

OBJECTIVE: To assess opinion of health professionals about adherence and management of long-term treatments in adolescents in a tertiary hospital. METHOD: A cross-sectional study was carried out in the Vall d'Hebron University Hospital in Barcelona, Spain. Participants were health professionals who care adolescents with solid organ transplant, hematologic disease, diabetes, cystic fibrosis or HIV+. Data collection was performed by self-administered questionnaire, developed specifically for this study. RESULTS: A total of 105 professionals (70%) participated in the study, 80% were nurses, 56% of them indicated that treatment compliance was good. 43% indicated that adherence was not addressed well and 79% of professionals did not have planned time to conduct health education related to treatment. 19.5% of nurses and 72.2% of physicians reported having adherence assessment tools. 39% of participants made suggestions for improvement. CONCLUSIONS: Almost half of the professional indicate that the adherence is not adequately addressed. It is important to evaluate adherence to treatment to identify causes of low compliance and establish and evaluate appropriate interventions.

A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data.

BACKGROUND: Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotavirus vaccines have now been developed and extensively studied for their potential association with IS. This study aimed to describe the epidemiology and to estimate the incidence of IS in Latin American infants prior to new vaccine introduction. METHODS: Children under 2 years of age representing potential IS cases were enrolled in 16 centers in 11 Latin American countries from January 2003 to May 2005. IS cases were classified as definite, probable, possible or suspected as stated on the Brighton Collaboration Working Group guidelines. RESULTS: From 517 potential cases identified, 476 (92%) cases were classified as definite, 21 probable, 10 possible and 10 suspected for intussusception. Among the 476 definite IS cases, the median age at presentation was 6.4 months with 89% of cases aged <1 year. The male to female ratio was 1.5:1. The incidence of definite IS per 100,000 subject-years ranged from 1.9 in Brazil to 62.4 in Argentina for children <2 years of age, and from 3.8 in Brazil to 105.3 in Argentina for children aged <1 year. Median hospital stay was 4 days with a high prevalence of surgery as the primary treatment (65%). Most cases (88%) made a complete recovery, but 13 (3%) died. No clear seasonal pattern of IS cases emerged. CONCLUSIONS: This study describes the epidemiology and estimates the incidence of IS in Latin American infants prior to the introduction of new rotavirus vaccines. The incidence of IS was found to vary between different countries, as observed in previous studies. TRIAL REGISTRATION: Clinical study identifier 999910/204 (SERO-EPI-IS-204).

Reproductive phenology and pre-dispersal fruit predation in Atriplex halimus L. (Chenopodiaceae).

BACKGROUND: The flowering phenology pattern of Atriplex halimus was studied in a Mediterranean habitat in order to analyze protandry effectiveness. Fruit set evolution was recorded over two years and the impact of pre-dispersal predation by insects was also evaluated. RESULTS: The flowering phenology coincided in 2006 and 2007, starting in mid-July and reaching full flowering at the end of August in both years. Inflorescences are composed of glomerules with 8.78 ± 2.79 male flowers and 4.57 ± 2.58 female flowers, with no significant differences in position on the inflorescence. The peaks of male and female flower anthesis were reached in mid-August, but the male maximum occurred one week before the female. Plants at the start of flowering only bear male flowers, but female flowers soon appear. Fruit set starts at the end of August; all the flowers were transformed into fruit by mid-September and their development continued to the beginning of October, when fruit structures had matured and began to drop. Fruit predation started at the end of September and reached maximum intensity in mid-October. CONCLUSIONS: At population level, male and female flowers seemed to open in the same weeks, but at plant and glomerule level male flowers opened one week before the females. Fruit predation levels were 62.42 and 43.14% in 2006 and 2007 respectively, with no significant differences between different parts of the inflorescence. And larvae of Coleophoridae were the most abundant predators.

Síndrome de apnea-hipopnea obstructiva del sueño e insomnio: una asociación frecuente / No disponible

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Effect of the seasoning method on the chemical composition of oak heartwood to cooperage.

The effect of various oak wood seasoning methods, natural seasoning in open air, artificial seasoning in a kiln, and a mixed method that combines open air and kiln drying, on the chemical composition in American ( Quercus alba) and French ( Quercus petraea) oak was studied. The results confirm the evolution of ellagitannins in wood, low molecular polyphenols, and volatile compounds in relation to oak species and seasoning method. Natural seasoning in open air can be considered a superior method to mixed or artificial drying for wood seasoning in cooperage. It was more effective in reducing the excess of ellagitannins, especially in French oak wood. Moreover, the evolution of wood volatile compounds was more positive in the natural seasoning than mixed or artificial drying, since it led to woods with higher aromatic potential (larger concentrations of compounds such as volatile phenols, phenolic aldehydes, furanic compounds, and cis- and trans-beta-methyl-gamma-octalactones) than mixed or artificial methods. However, the three seasoning methods showed similar effectiveness regarding the desired reduction of off-flavors compounds.

Trastorno alimentario en relación con el sueño / Sleep related eating disorder

INTRODUCCIÓN. El trastorno alimentario relacionado con el sueño (SRED) se caracteriza por la presencia de arousals nocturnos acompañados de alimentación compulsiva, con nivel de conciencia variable durante los mismos. Con frecuencia el trastorno se acompaña de otras alteraciones del sueño, pero la mayoria de casos publicados no aportan estudios polisomnográficos nocturnos (PSGn). Caso1 Varón de 40 años de edad. Desde los 25 años presenta episodios de levantarse de la cama por la noche para ingerir alimento, recordando el episodio vagamente o sin recordarlo. Refiere antecedentes de sonambulismo personales y familiares. El PSGn muestra la presencia de movimientos periódicos de piernas. Caso 2 Varón de 42 años de edad con historia personal y familiar de sonambulismo. Desde hace varios años presenta episodios de alimentación compulsiva durante la noche que no recuerda al día siguiente. Su PSGn muestra apneas obstructivas relacionadas con la posición del cuerpo. Caso 3 Varón de 40 años con gran cantidad de arousals durante el sueño, durante los que siente la necesidad de comer. Al día siguiente recuerda los episodios. Su PSGn muestra la presencia de escasas apneas. CONCLUSIÓN. El SRED puede estar asociado con otras alteraciones del sueño. Su diagnóstico mediante la ayuda del PSGn y su tratamiento pueden mejorar y hacer que los episodios disminuyan en frecuencia (AU)

INTRODUCTION. Sleep - related eating disorder (SRED) is characterised by arousals from sleep associated with compulsive ingestion of food and subsequent poor memory of the event. SRED is frequently combined with other sleep disorders, but most published reports do not include polysomnografic (PSG) studies. Case 1 Male patient, 40 years old. At age 25 he started getting up every night and eating food with only partial or no recall of the event. He has personal and family history of sleepwalking. His PSG showed the presence of periodic limb movements. Case 2 Male patient, 42 years old with history of sleep walking. Several years ago he started compulsive eating at night without recall of the episode. His PSG showed obstructive sleep apneas related to body position. Case 3 Male patient 40 years old with many arousals from sleep, during which he feels the need to eat. The next day he recalls the episodes. His PSG showed a few obstructive sleep apneas. CONCLUSION. SRED may be associated with other sleep disorders. Their diagnosis by PSG study, and their treatment may improve and decrease the frequency of the events (AU)