RESUMO
No disponible
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Síndrome de Emaciação/complicações , Síndrome de Emaciação/diagnóstico , Palidez/complicações , Determinação da Pressão Arterial/métodos , Tireoidite/diagnóstico , Anamnese/métodos , Pressão Arterial/fisiologia , Glândula Tireoide/patologia , Glândula Tireoide , Estudos Transversais/métodos , Cintilografia/métodos , CintilografiaRESUMO
We studied the receptivity of a population of HIV-infected patients to the development of a group educational intervention in order to enhance the adherence to therapy. We designed a group educational activity conducted by family physicians and directed to patients with HIV infection treated with antiretrovirals for at least six months. We conducted a randomized trial that compared two interventions: an educational intervention plus individual counsel or the last option alone. We studied their clinical situation, adherence to therapy and familial support. We offered 115 patients (66.9% injection drug users (IDUs), 69.6% males) the opportunity to be included in our trial, but 73.9% of them refused. No group with four or more participants was formed. Fifty-nine per cent refused to be included claiming personal reasons and 32.9% cited trouble in their jobs. There was a non-significant trend to accept in the case of women (p = 0.19), patients with AIDS (p = 0.11) and non-adherent patients (p = 0.08). This trend was significant in the group of women with AIDS (p = 0.01) and non-adherent women (p = 0.05). We concluded that HIV-infected patients, mainly IDUs, are not receptive to group educational programmes. The design of future interventions must take into account the patients' characteristics.
Assuntos
Atitude , Infecções por HIV/psicologia , Cooperação do Paciente , Educação de Pacientes como Assunto , Psicoterapia de Grupo , Adulto , Fármacos Anti-HIV/uso terapêutico , Feminino , Infecções por HIV/tratamento farmacológico , Infecções por HIV/prevenção & controle , Humanos , Masculino , Pessoa de Meia-Idade , Autocuidado , Abuso de Substâncias por Via Intravenosa , Resultado do TratamentoRESUMO
Experimental studies on mitomycin-C nephrotoxicity are scanty and mention the occurrence of cortical hemorrhage, tubular necrosis, or hydronephrosis secondary to papillomatous hyperplasia of the uroepithelium. To our knowledge, only one experimental study has mentioned morphological lesions similar to the hemolytic uremic syndrome in the human. In the present study 40 female Wistar rats were studied following unilateral renal perfusion of the left kidney with 2 mg/kg of mitomycin-C. Renal lesions corresponded to cortical necrosis with the presence of large bizarre nuclei. The presence of these nuclear atypias supports a direct toxic effect (alkylation) of the mitomycin or its metabolites on cells.
