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Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region. Although dysbiosis of the local microbial community initiates local inflammation, over-activation of the host immune response directly activates osteoclastic activity and alveolar bone loss. Many studies have reported on the cytokine network involved in periodontitis and its crucial and pleiotropic effect on the recruitment of specific immunocytes, control of pathobionts and induction or suppression of osteoclastic activity. Nonetheless, particularities in the stimulation of pathogens in the oral cavity that lead to the specific and complex periodontal cytokine network are far from clarified. Thus, in this review, we begin with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response. In addition, we also summarize the latest cytokine-related therapeutic measures for periodontal disease.
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Humanos , Perda do Osso Alveolar , Citocinas , Metabolismo , Fisiologia , Inflamação , Doenças Periodontais , Periodontite , Alergia e Imunologia , Microbiologia , Fator de Necrose Tumoral alfa , FisiologiaRESUMO
Objective To understand the epidemiological and etiological characteristics of mumps in Fujian province,2005-2017.Methods All the reported mumps cases were collected through the National Notifiable Disease Information Management System,2005-2017.Active search and interviews were conducted to collect the information on vaccination of mumps.Throat swab specimens were collected for cells culture,genotyping and gene sequence analysis on mumps virus (MuV).Results A total of 83 959 cases of mumps were reported in Fujian province from 2005 to 2017,with an average annual incidence of 17.6 per 100 000.Since 2007,the incidence appeared increasing but then decreasing,reaching the lowest level (7.5 per 100 000),after the setup of a monitoring program.Annually,the onset time of mumps showed an obvious two seasonal peaks,one from April to July,with a weakening trend,and the other from October to January with a rising trend.Most of the mumps cases occurred among students,kindergarten and scattered children (89.2％,5 814/6 517),children aged 5-9 years (38.8％,2 527/6 517),with cases reported from every region.Program from the pathogen surveillance showed that the transmission chain of G genotype mumps virus did exist in Fujian.Data from the sequence analysis revealed that mutations in the nucleotide of G genotype strain in 2015 had led to mutation of 6 amino acid sites in the SH gene coding region,resulting in the differences appearing in both nucleotide and amino acid homology with type A vaccine strain.Conclusions The incidence of mumps decreased annually,in Fujian.Prevention programs should focus on primary and secondary school students.In Fujian province,we also noticed the transmission chain of mumps G genotype with some amino acid mutations in the SH gene coding region.Monitor programs on both epidemiologic and etiology,should be strengthened.
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Objective To understand the epidemiological and etiological characteristics of mumps in Fujian province,2005-2017.Methods All the reported mumps cases were collected through the National Notifiable Disease Information Management System,2005-2017.Active search and interviews were conducted to collect the information on vaccination of mumps.Throat swab specimens were collected for cells culture,genotyping and gene sequence analysis on mumps virus (MuV).Results A total of 83 959 cases of mumps were reported in Fujian province from 2005 to 2017,with an average annual incidence of 17.6 per 100 000.Since 2007,the incidence appeared increasing but then decreasing,reaching the lowest level (7.5 per 100 000),after the setup of a monitoring program.Annually,the onset time of mumps showed an obvious two seasonal peaks,one from April to July,with a weakening trend,and the other from October to January with a rising trend.Most of the mumps cases occurred among students,kindergarten and scattered children (89.2％,5 814/6 517),children aged 5-9 years (38.8％,2 527/6 517),with cases reported from every region.Program from the pathogen surveillance showed that the transmission chain of G genotype mumps virus did exist in Fujian.Data from the sequence analysis revealed that mutations in the nucleotide of G genotype strain in 2015 had led to mutation of 6 amino acid sites in the SH gene coding region,resulting in the differences appearing in both nucleotide and amino acid homology with type A vaccine strain.Conclusions The incidence of mumps decreased annually,in Fujian.Prevention programs should focus on primary and secondary school students.In Fujian province,we also noticed the transmission chain of mumps G genotype with some amino acid mutations in the SH gene coding region.Monitor programs on both epidemiologic and etiology,should be strengthened.
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BACKGROUND:Absorbable colagen membrane can be theoreticaly applied to secondary alveolar bone grafting in alveolar cleft surgery, which can improve the bone preservation and slow bone resorption. However, there is stil no unified conclusion. OBJECTIVE:To assess the efficacy and safety of absorbable colagen membrane for secondary alveolar bone grafting viaa systematic review. METHODS:MEDLINE, EMBASE, CBM and CAJD were searched for eligible articles addressing clinical randomized controled or controled trials of absorbable colagen membrane for secondary alveolar bone grafting. Test group received bone grafting with absorbable colagen membrane and control group only received bone grafting. Meta-analysis on the clinical success rate of bone grafting and incidence of complications in the recipient region was delivered with Revman 5.3. RESULTS AND CONCLUSION:Five clinical trials, involving 416 cleft sites and 387 participants, were included. Two had high risk of bias and the rest had unclear risk of bias. If “the height of new bone is≥ 50% of alveolar height” was adopted as clinical success, the clinical success rate of the test group was significantly higher than that of the control group (P=0.002, relative risk value=1.33, 95% confidence interval [1.11, 1.60]). If “the height of new bone is≥ 75% of alveolar height” was chosen as clinical success, the clinical success rate of the test group was higher than that of the control group, but there was no significant difference between the two groups (P=0.06, relative risk value=1.40, 95% confidence interval [0.99, 1.99]). For safety, the use of absorbable colagen membrane could not increase the complications incidence (P=0.35, relative risk value=0.66, 95% confidence interval [0.28, 1.58]). So, the use of absorbable colagen membrane is safe to improve the clinical success rate of secondary alveolar bone grafting in alveolar cleft surgery. More randomized controled trials should be considered to reinforce the conclusion.
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BACKGROUND:There are numerous clinical studies on comparing absorbable internal fixation system and titanium metal internal fixation system in maxilofacial fractures; however, the systematic reviews and Meta-analysis in this field are rare. OBJECTIVE:To compare the clinical effect of absorbable internal fixation system and titanium internal fixation system in maxilofacial fractures through systematic review and Meta-analysis. MATERIALS AND METHODS:The randomized controled trials and controled clinical trials regarding the application of absorbable internal fixation system and titanium internal fixation system in maxilofacial fractures were electronicaly retrieved from Medline, Embase, the Cochrane Central Register of Controled Trials, China Biology Medicine disc, and China Academic Journal Network Publishing Database using the keywords. Meta-analysis was conducted using Revman 5.3 software. RESULTS AND CONCLUSION:Thirteen clinical studies were included, and totaly 1 718 patients were involved. The Meta-analysis results showed that the removal rate of implants in the absorbable internal fixation system group was significantly lower than that in the titanium internal fixation group (P=0.000 2); there were no significant differences in the healing rate of fracture I stage, the incidence of insufficient fixation in fracture site and the incidence of long-term complications between these two groups. These results demonstrate that the efficiency and safety of absorbable internal fixation system in maxillofacial fracture is satisfactory, and can reduce the proportion of secondary surgical removal of the implant. More randomized controlled trials should be conducted to confirm this conclusion.
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<p><b>OBJECTIVE</b>To investigate the difference in mental health status of oral tumor patients and their spouses, and explore the differences on the basis of relevant materials.</p><p><b>METHODS</b>Forty patients with oral cancer, eighteen spouses, and thirty-five patients with oral benign tumor were diagnosed in the West China Hospital of Stomatology between December 2011 and August 2012 and assessed with symptom checklist-90 (SCL90) (the 5-grade scoring). Participants were assessed independently according to their conditions. Blood samples were obtained from the participants by syringe on the second admission day. A method was developed to determine the concentrations of catecholamine and glucocorticoid in the serum using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).</p><p><b>RESULTS</b>The scores for compel, depression and rests in the cancer group and benign tumor group were statistically significant (P<0.05). The scores for compel, dread and stubborn in the cancer group and their spouses were statistically significant (P<0.05). The differences between the total and other monomial factor scores were not statistically significant. However, the contents of epinephrine, norepinephrine, cortisone and hydrocortisone in the serum, as determined by HPLC-MS/MS, were significantly different (P<0.001).</p><p><b>CONCLUSION</b>Psychiatric factors do not show a simple factor effect on patients. Symptoms of patients may be based on tumorigenesis and developed in small molecules. Further research is required.</p>
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Humanos , Biomarcadores , China , Nível de Saúde , Saúde Mental , Neoplasias Bucais , Neoplasias , Espectrometria de Massas em TandemRESUMO
Objective To analyze testing results and values of blood heterotypic lymphocyte in flu patients.Methods 100 cases of influenza patients and 100 healthy people were collected.The observation group for flu patients and control group of healthy people.Extraction of peripheral blood in patients with microscopic examination observing leukocyte,neutrophil,lymphocyte,intermediate cells,atypical lymphocytes under a microscope,and calculated the percentage in the patients in the two group cells to make analysis and comparison.Ratio in peripheral blood of patients and analysis of specific lymphocytes were also calculated between different ages.Results Peripheral blood lymphocytes in observation group was (11.1 ± 2.6) ％,which was significantly higher than than of the control group [(1.5 ± 0.5) ％].The difference was statistically significant (chi-square =16.9,P ＜ 0.05) ; White blood cells,the ratio of neutrophils,lymphocytes in observation group were obvious differenent compared with the control group(t/chi square are:13.2,11.3 and 12.6,P ＜ 0.05) ;Three ages of influenza patients peripheral blood lymphocytes of the opposite sex ratio has no difference(P ＞ 0.05).Conclusion Detection of peripheral blood lymphocyte heterosexual has great significance to the diagnosis of influenza with simple,convenient and feasible characters.It is worth to be used widely in clinical practice.
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Objective To study CT and MRI features and classification of brain schistosomiasis granuloma. Methods CT and MRI data of 30 cases of brain schistosomiasis granuloma were reviewed.All cases were proved by the surgery or pathological examination and clinical laboratory test.There were 20 males and 10 females, and their age ranged from 5 to 58 years, mean 29.2 years.Plain and enhanced CT were performed in all patients with GE MAX 640 scanner.Ten patients were examined by plain and enhanced MRI with GE Signa profile 0.2 Tesla open scanner.Results The lesions located in supratentorial region in 27 cases and in infratentorial region in 3cases.The nodules were isodense or slight hyperdense on CT plain scan, iso or hypointense on T_1WI, hyperintense on T_2WI, Slight hyperintense on FLAIR.After the contrast material was injected intravenously, CT and MRI findings were multiple or single enhanced nodules at the cortical or subcortical area.There were four types of imaging features: (1) multiple small nodules in 5 cases (presenting as bright stars in the dark sky); (2) single large nodule in 8 cases; (3) mixed nodules in 14 cases; (4) circle-enhanced nodules in 3 cases.Conclusion The brain schistosomiasis granuloma has typical CT and MRI findings.CT and MRI classification is not only helpful to its diagnosis and differential diagnosis, but also might be useful for the choice of clinical treatment.
