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1.
Sleep Sci ; 15(Spec 1): 278-284, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35273778

RESUMO

Introduction: Studies have shown that narcolepsy patients may present with low serum acylcarnitine levels, demonstrating a dysfunctional beta fatty acid oxidation pathway in these patients. Objective: Evaluate the therapeutic efficacy of L-carnitine as a treatment for narcolepsy patients. Methods: This study runned in form of systematic review. The terms used for the search: ("narcolepsy"[MeSH Terms] OR "narcolepsy"[All Fields]) AND ("carnitine"[MeSH Terms] OR "carnitine"[All Fields] OR "l carnitine"[All Fields]). Were included all surveys published until January 2021, with the diagnosis of narcolepsy, that performed drug treatment with I-carnitine. The clinical endpoints of interest were: excessive daytime sleepiness, dissociative REM sleep manifestations: cataplexy, sleep paralysis, hypnagogic hallucinations, and early REM sleep (REM sleep naps, SOREMP). Results: L-carnitine was found to be well-tolerated and without side effects in all surveys, at dosages ranging from 500 to 510 mg/day. Newborns did not present complications during delivery. Conclusion: This study corroborates the efficacy and good tolerability of L-carnitine therapy as a treatment for patients with narcolepsy, including during pregnancy.

3.
Bioorg Med Chem Lett ; 30(19): 127454, 2020 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-32736078

RESUMO

Prostate cancer is an important cause of death in the male population and for which there is no satisfactory chemotherapy. Herein a new series of chalcone hybrids containing 2H-1,2,3-triazole core as the ring B has been synthesized and evaluated in vitro against PC-3 prostate cancer cell line. Compounds 4a, 4c and 4e significantly reduced cell viability and showed IC50 of 28.55, 15.64 and 25.56 µM, respectively. The structure-activity relationship supported by computational chemistry points that the polarity of the molecular surface area should have some relevance to the efficiency of the compounds, in particular the ratio of the partial positive charge sites and the total molecular surface area exposed to the cell environment.


Assuntos
Antineoplásicos/farmacologia , Chalconas/farmacologia , Neoplasias da Próstata/tratamento farmacológico , Triazóis/farmacologia , Antineoplásicos/síntese química , Chalconas/síntese química , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Masculino , Estrutura Molecular , Células PC-3 , Relação Quantitativa Estrutura-Atividade , Triazóis/síntese química
4.
Acta Crystallogr E Crystallogr Commun ; 75(Pt 6): 738-741, 2019 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-31391956

RESUMO

In the mol-ecular structure of the title compound, C10H10N4O2·H2O, the angle between the triazole and arene rings is 87.39 (5)°. The water of crystallization connects the mol-ecules in the crystal packing. The crystal structure exhibits N-H⋯O, O-H⋯O and O-H⋯N inter-actions, resulting in the formation of a three-dimensional framework. The inter-molecular inter-actions were identified and qu-anti-fied using Hirshfeld surface analysis.

5.
Beilstein J Org Chem ; 15: 388-400, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30873225

RESUMO

4-Oxoquinolines are a class of organic substances of great importance in medicinal chemistry, due to their biological and synthetic versatility. N-1-Alkylated-4-oxoquinoline derivatives have been associated with different pharmacological activities such as antibacterial and antiviral. The presence of a carboxamide unit connected to carbon C-3 of the 4-oxoquinoline core has been associated with various biological activities. Experimentally, the N-ethylation reaction of N-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide occurs at the nitrogen of the oxoquinoline group, in a regiosselective way. In this work, we employed DFT methods to investigate the regiosselective ethylation reaction of N-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide, evaluating its acid/base behavior and possible reaction paths.

6.
J Biol Inorg Chem ; 23(8): 1227-1241, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30145655

RESUMO

With the increasing life expectancy of the world's population, neurodegenerative diseases, such as Alzheimer's disease (AD), will become a much more relevant public health issue. This fact, coupled with the lack of efficacy of the available treatments, has been driving research directed to the development of new drugs for this pathology. Metal-protein attenuating compounds (MPACs) constitute a promising class of agents with potential application on the treatment of neurodegenerative diseases, such as AD. Currently, most MPACs are based on 8-hydroxyquinoline. Recently, our research group has described the hybrid aroylhydrazone containing the 8-hydroxyquinoline group INHHQ as a promising MPAC. By studying the known structure-related ligand HPCIH, which does not contain the phenol moiety, as a simplified chemical model for INHHQ, we aimed to clarify the real impact of the aroylhydrazone group for the MPAC activity of a compound with potential anti-Alzheimer's activity. The present work describes a detailed solution and solid-state study of the coordination of HPCIH with Zn2+ ions, as well as its in vitro binding-ability towards this metal in the presence of the Aß(1-40) peptide. Similar to INHHQ, HPCIH is able to efficiently compete with Aß(1-40) for Zn2+ ions, performing as expected for an MPAC. The similarity between the behaviors of both ligands is remarkable. Taken together, the data presented herein point to aroylhydrazones, such as the compounds HPCIH and the previously published INHHQ, as encouraging MPACs for the treatment of AD.


Assuntos
Hidrazonas/química , Nootrópicos/química , Piridinas/química , Zinco/química , Doença de Alzheimer/tratamento farmacológico , Peptídeos beta-Amiloides/metabolismo , Complexos de Coordenação/síntese química , Complexos de Coordenação/química , Complexos de Coordenação/metabolismo , Hidrazonas/síntese química , Hidrazonas/metabolismo , Ligantes , Estrutura Molecular , Nootrópicos/síntese química , Nootrópicos/metabolismo , Fragmentos de Peptídeos/metabolismo , Estudo de Prova de Conceito , Ligação Proteica , Piridinas/síntese química , Piridinas/metabolismo , Zinco/metabolismo
7.
J Pharm Sci ; 107(2): 672-681, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29031975

RESUMO

A new monohydrated polymorph of dexamethasone acetate was crystallized and its crystal structure characterized. The different analytical techniques used for describing its structural and vibrational properties were: single crystal and polycrystal X-ray diffraction, solid state nuclear magnetic resonance, infrared spectroscopy. A Hirshfeld surface analysis was carried out through self-arrangement cemented by H-bonds observed in this new polymorph. This new polymorph form appeared because of self-arrangement via classical hydrogen bonds around the water molecule.


Assuntos
Dexametasona/análogos & derivados , Cristalização/métodos , Cristalografia por Raios X/métodos , Dexametasona/química , Ligação de Hidrogênio , Espectroscopia de Ressonância Magnética/métodos , Água/química , Difração de Raios X/métodos
8.
Rev. CEFAC ; 18(1): 151-157, jan.-fev. 2016. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: lil-775670

RESUMO

RESUMO Objetivo: caracterizar a assistência hospitalar em pacientes com câncer de laringe, na perspectiva da intervenção cirúrgica e reabilitação fonoaudiológica ofertada pelo Sistema Único de Saúde (SUS) na região Nordeste. Métodos: estudo epidemiológico descritivo, que contou com dados secundários obtidos via consulta à base de dados DATASUS, tendo levantado informações referentes ao período de janeiro de 2008 a dezembro de 2012. Resultados: aumento do número de casos de câncer de laringe com o passar dos anos, predominância do sexo masculino, aumento no número de internações, laringectomia parcial como procedimento médico mais utilizado e a maior quantidade de fonoaudiólogos vinculados ao SUS foi observada em Pernambuco. Conclusão: a assistência hospitalar aos pacientes com câncer de laringe contempla estratégias como procedimentos cirúrgicos e intervenção fonoaudiológica. Faz-se necessário que essa assistência contemple aspectos direcionados à prevenção de doenças, pois a informação em saúde, por meio de estratégias educativas, pode contribuir para o diagnóstico precoce e tratamento da doença.


ABSTRACT Purpose: to describe the hospital care provided to patients with laryngeal cancer in the Northeast of Brazil and the possibilities of surgical intervention and speech rehabilitation funded by Brazil's unified health system (SUS). Methods: this is a descriptive epidemiological study, which relied on secondary data obtained by searching the DATASUS database for information referring to the period between January 2008 and December 2012. Results: the study showed an increase in the number of cases of laryngeal cancer over the years, a predominance of male patients, and a larger number of hospitalizations; it also evidenced that the partial laryngectomy is the most frequent medical procedure, and that the state of Pernambuco has the largest number of speech therapists associated with the SUS. Conclusion: the provision of hospital care to patients with laryngeal cancer contemplates strategies such as surgical procedures and speech rehabilitation. This care should include aspects associated with disease prevention, as health information conveyed by means of educational programs may contribute to the early diagnosis and treatment of the illness.

9.
Rev. CEFAC ; 15(6): 1525-1532, nov.-dez. 2013. ilus, tab
Artigo em Português | LILACS-Express | LILACS | ID: lil-700046

RESUMO

OBJETIVO: observar se existe relação entre a preferência do lado mastigatório, antropometria facial e atividade elétrica do músculo masseter em laringectomizados totais. MÉTODOS: a coleta de dados, realizada no setor de Fonoaudiologia do Hospital de Câncer de Pernambuco (HCP), contou com a participação de quinze voluntários laringectomizados totais do gênero masculino e idade média de 64 anos. Foi realizada aferição das distâncias entre os pontos antropométricos faciais ex e ch nas hemifaces dos voluntários e posteriormente executado exame eletromiográfico dos músculos masseteres, bilateralmente, nos momentos de máxima intercuspidação habitual (MIH), mastigações unilaterais direita e esquerda e durante mastigação habitual. Realizou-se filmagem durante a mastigação habitual para identificação do lado de preferência mastigatória. RESULTADOS: os indivíduos cuja preferência mastigatória foi do lado direito, apresentaram o lado esquerdo da face com maior medida (72,37mm); já os indivíduos cuja preferência mastigatória foi do lado esquerdo, apresentaram maior medida da face do lado direito (68,85mm). Quando a mastigação apresentou-se unilateral direita a atividade elétrica do masseter direito atingiu média de 123,57% enquanto o masseter esquerdo alcançou média igual a 84,85% de atividade em relação à MIH (p = 0,016). CONCLUSÃO: em laringectomizados as medidas antropométricas faciais correlacionam-se com o lado de preferência de mastigação e os valores eletromiográficos dos masseteres durante a mastigação.


PURPOSE: to observe whether a relationship exists between the preference of chewing side, facial anthropometry and electrical activity of masseter muscle in total laryngectomy. METHODS: data collection, performed in the Speech Therapy Cancer Hospital of Pernambuco (HCP), with the participation of fifteen volunteers laryngectomized males and mean age of 64 years. We performed measurement of distances between points and anthropometric facial ex ch in hemifaces of volunteers and later executed EMG of the masseter muscles, bilaterally, in his habitual intercuspal (MHI), unilateral right and left chewing and during mastication. Filming took place during mastication to identify the side of the preference side. RESULTS: individuals whose right side is the masticatory predominance showed of the left side of the face to a greater extent (72.37 mm), while those whose prevalence of side left masticatory had higher estensão the side right (68.85 mm). In unilateral chewing right the electrical activity of the right masseter had an average 123.57% , while the left masseter showed an average 84.85% of the activity in relation to MHI (p = 0.016). CONCLUSION: in laryngectomized anthropometric facial measurements correlate with the preference side chewing and the values of the masseter EMG during mastication.

10.
Interaçao psicol ; 16(2): 173-183, jul.-dez. 2012.
Artigo em Português | LILACS | ID: lil-680292

RESUMO

O presente estudo treinou o responder por exclusão em cães por meio do ensino de discriminações condicionais entre objetos e seus respectivos nomes ditados e avaliou empiricamente a influência neste desempenho de dicas sociais humanas (gestos direcionados aos estímulos) quando estas eram direcionadas ao estímulo contrário. Os dois animais demonstraram rápida aquisição de controle pelo estímulo novo, controle que se manteve mesmo com a inserção de dicas sociais contrárias ao estímulo ditado (instruir oralmente a seleção de S+, porém apontar para S-). Foi evidente a influência das dicas sociais contrárias quando os estímulos eram familiares, com ruptura do controle preestabelecido. Discute-se a relevância deste estudo na comparação de diferentes aspectos do ambiente no comportamento canino, e enfatiza-se a necessidade de incluir sondas de controle pela novidade, para pesquisas futuras


This study trained the responding by exclusion in dogs, based on a conditional discrimination between dictated names and objects, and empirically evaluated the influence in that performance of human social cues (gestures directed to stimuli) towards the opposite stimulus. As a result, both animals showed rapid acquisition of control by the new stimulus, a pattern that persisted even after the inclusion of conflicting social cues toward the wrong stimulus (orally instructing the selection of S+, but pointing to the S-). The influence of conflicting social cues when the stimuli involved were familiar is clear, a pattern showed by the disruption of pre-established control. We discuss the relevance of this study in the comparison of different aspects of the environment on the behavior of dogs, and the need to include control probes for novelty in future research is emphasized


Assuntos
Animais , Cães/psicologia , Aprendizagem por Discriminação
11.
Interação psicol ; 16(2): 173-183, jul.-dez. 2012.
Artigo em Português | Index Psicologia - Periódicos | ID: psi-57090

RESUMO

O presente estudo treinou o responder por exclusão em cães por meio do ensino de discriminações condicionais entre objetos e seus respectivos nomes ditados e avaliou empiricamente a influência neste desempenho de dicas sociais humanas (gestos direcionados aos estímulos) quando estas eram direcionadas ao estímulo contrário. Os dois animais demonstraram rápida aquisição de controle pelo estímulo novo, controle que se manteve mesmo com a inserção de dicas sociais contrárias ao estímulo ditado (instruir oralmente a seleção de S+, porém apontar para S-). Foi evidente a influência das dicas sociais contrárias quando os estímulos eram familiares, com ruptura do controle preestabelecido. Discute-se a relevância deste estudo na comparação de diferentes aspectos do ambiente no comportamento canino, e enfatiza-se a necessidade de incluir sondas de controle pela novidade, para pesquisas futuras (AU)


This study trained the responding by exclusion in dogs, based on a conditional discrimination between dictated names and objects, and empirically evaluated the influence in that performance of human social cues (gestures directed to stimuli) towards the opposite stimulus. As a result, both animals showed rapid acquisition of control by the new stimulus, a pattern that persisted even after the inclusion of conflicting social cues toward the wrong stimulus (orally instructing the selection of S+, but pointing to the S-). The influence of conflicting social cues when the stimuli involved were familiar is clear, a pattern showed by the disruption of pre-established control. We discuss the relevance of this study in the comparison of different aspects of the environment on the behavior of dogs, and the need to include control probes for novelty in future research is emphasized (AU)


Assuntos
Animais , Cães/psicologia , Aprendizagem por Discriminação
12.
J Voice ; 26(6): 813.e1-7, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23041165

RESUMO

PURPOSE: To investigate which muscular maneuvers provide larger electric activity (EA) of the suprahyoid (SH) and infrahyoid (IH) muscles to be used as surface electromyography (SEMG) signal normalization reference. METHODS: The electrical potentials of the SH and IH muscles of 12 subjects were evaluated using six muscular maneuvers, involving the position of the tongue and effort. It was selected as maximum voluntary sustained activity maneuver, the one having the minor coefficient of variation and the smallest value for each muscle group. The EA signal was converted using the root mean square in microvolts. It was considered then the maximum signal of each maneuver as the difference between the mean of three measures and the resting potential. RESULTS: The maneuvers that provided higher mean potentials with minor coefficient of variation and smallest P value were incomplete swallowing (IS) with effort (mean potential equal to 56.73±8.68 with coefficient of variation of 15.30%) in SH group, and tongue retracted with mouth open (TROM, mean potential equal to 46.57±7.83 with coefficient of variation of 16.81%) in IH group. CONCLUSION: The IS with effort and TROM maneuvers should be considered for signal normalization in these muscles, respectively, and may provide conditions for using the SEMG in voice clinic. SIGNIFICANCE: The use of normalization standards in researches of SH and IH muscles in the voice area will allow comparisons among future works.


Assuntos
Deglutição , Eletromiografia , Contração Isométrica , Músculos Laríngeos/fisiologia , Processamento de Sinais Assistido por Computador , Língua/fisiologia , Potenciais de Ação , Adolescente , Adulto , Eletromiografia/normas , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Movimento , Valores de Referência , Volição , Adulto Jovem
13.
Temas psicol. (Online) ; 16(2): 261-271, dez. 2008. ilus
Artigo em Português | Index Psicologia - Periódicos | ID: psi-51938

RESUMO

Análises prévias da interação de uma criança com Síndrome de Down e seus pares em uma creche indicaram dois grandes problemas: pouca aceitação pelos colegas e mediação falha das educadoras na interação entre as crianças. O presente estudo implementou e avaliou um programa de intervenção baseado na análise funcional do comportamento para proporcionar formação para os educadores solucionarem tais problemas, lidando com comportamentos desafiadores exibidos pela criança, mediando sua interação com os colegas e otimizando sua escolarização como um todo. A intervenção foi baseada na consultoria colaborativa e consistiu em discussões com os educadores acerca da identificação das funções comportamentais dos comportamentos-problema para delineamento de estratégias para solucioná-los. Ao final do programa, observaram-se salientes mudanças comportamentais exibidas tanto pela criança com deficiência, quanto pelas educadoras, com diminuição significativa dos comportamentos inadequados identificados pela análise funcional (agressivos e disruptivos), bem como aumento de intervenções efetivas, de acordo com a função comportamental.(AU)


Previous analysis of the interaction patterns among a Down Syndrome child and peers in a regular school identified two major problems: fewer acceptance by other children, and flaw mediation of interaction among children. The present research designed, implemented and evaluated an intervention program for this classroom, based on functional analysis procedures, so the teachers could solve these problems, dealing with the child challenging behaviors, mediating interaction and improving the inclusion process in their class. The intervention was based on the co-operative consultancy and consisted on discussions with educators about problems found by using functional analysis and designed strategies to solve them, based on their behavioral function. At the end of the program, child and teacher achieved important behavioral changes. These may be concluded by the expressive decrease of both classes of problem behavior defined as intervention targets (Heteroagressive and Disruptive Behaviors), and also by the expressive growth of effective interventions according to behavior function.(AU)

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