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1.
Artigo em Inglês | MEDLINE | ID: mdl-34212325

RESUMO

Upgradation of pyrolysis oil is a key process to achieve high-quality biofuel. In this study, the effects of different Ar pressures and H2/Ar ratios in the presence and absence of catalysts on deoxygenation of pyrolysis oil were investigated by autoclaving. When the initial pressure of the reaction is 6MPa and without catalyst addition, the content of carboxylic acid decreases from 51.52 to 41.54%, whereas with the addition of catalyst (10 % Ni/C), the deoxygenation and hydrocarbon content in the product were significantly improved. Hence, 6 MPa was found to be optimum and above which failed to induce such useful changes but can lead to lower high heating value (HHV). However, the presence of hydrogen affects the content of alkanes and olefins in the product.

2.
Molecules ; 26(13)2021 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-34209219

RESUMO

Ginkgo biloba L. has always been a popular area of research due to its various active ingredients and pharmacological effects. Ginkgo biloba is rich in ginkgo flavonoids, ginkgolides, and ginkgolic acid, with anti-inflammation, antioxidation, neuroprotection, anti-platelet agglutination, hypolipidemic effect, anti-cancer, and anti-radiation properties. There are many methods to extract and separate the active components of ginkgo. Among them, supercritical carbon dioxide fluid extraction (SFE-CO2) is known for its green, clean, and environment-friendly properties. In this paper, the pharmacological activities, the active components, and structures of different parts of ginkgo, the extraction methods of its effective ingredients, and the application of the SFE-CO2 method for the extraction and separation of active ingredients in Ginkgo biloba from leaves, seeds, pollen, and roots were reviewed, in order to make best use of ginkgo resources, and provide support and references for the development of SFE-CO2 of active components from Ginkgo biloba.


Assuntos
Dióxido de Carbono/química , Ginkgo biloba/química , Ginkgolídeos , Extratos Vegetais/química , Folhas de Planta/química , Ginkgolídeos/química , Ginkgolídeos/isolamento & purificação
3.
Ann Palliat Med ; 2021 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-34263629

RESUMO

BACKGROUND: Tripterygium glycosides (TGs) has been widely used in the treatment of Sjögren's syndrome (SS). METHODS: Seven databases, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Medical Database, China Science and Technology Journal Database, and the Chinese Biomedicine database, were selected to collect randomized controlled trials (RCTs) related to the treatment of SS with TGs alone or in combination. The participants, intervention, comparison, outcome, and study design principle were adopted for the inclusion of related studies. The risk of bias was assessed using the Cochrane Collaboration's tool. Meta-analysis was conducted using RevMan 5.3, with risk ratios (RRs) or standard mean differences (SMDs) and 95% confidence intervals (CIs). RESULTS: Overall, 12 trials involving 668 patients were analyzed. The results of the meta-analysis showed that TGs in combination with total glucosides of paeony (TGP) had significantly lower symptom scores than TGs alone on dry eyes (SMD =-0.61, 95% CI: -1.12 to -0.10, P=0.02) or dry mouth (SMD =-1.29, 95% CI: -1.84 to -0.74, P<0.00001). The efficacy rates of TG + TGP vs. TGs (P<0.00001) and TG + HM vs. TGs (P=0.01) were significantly different. In addition, compared to hydroxychloroquine (HCQ), TGs could induce expression of C-reactive protein (P=0.007), globulin (P<0.00001), and immunoglobulin A (IgA) (P=0.006), whereas the TG + TGP group had lower levels of immunoglobulin G (IgG) (P<0.00001), immunoglobulin M (IgM) (P=0.02), and IgA (P<0.00001), as well as saliva flow rate (P<0.00001) and lacrimal gland function (P<0.00001). The adverse events between TGs and HCQ were not evident, and there was no increase in the risk of adverse reactions when combined with other drugs. DISCUSSION: TGs are potentially effective for treating SS without increasing the risk of adverse events. High-quality, multi-center, and large-scale RCTs are required.

4.
Intensive Crit Care Nurs ; : 103106, 2021 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-34246526

RESUMO

OBJECTIVE: To evaluate the incidence and risks factors of short-term post-intensive care (ICU) cognitive impairment. DESIGN: Prospective, observational study. SETTING: Closed university-affiliated intensive care unit. PATIENTS: We enrolled consecutive patients >18 yrs of age expected to be in intensive care unit for ≥24 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The score of Montreal Cognitive Assessment (MoCA) less than 26 was defined as cognitive impairment at hospital discharge and short-term post-ICU cognitive impairment was diagnosed in 185 of 409 assessed patients (45.2%). According to univariate analysis, age, years of education, occupation, past medical history, main ICU diagnosis, Acute Physiology and Chronic Evaluation Scoring System (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score, Charlson comorbidity index, ICU length-of-stay (LOS), total hospital LOS, sedation, vasoactive agents, muscle relaxants, mechanical ventilation and duration of mechanical ventilation, constraints, early active mobilisation, hypoxemia, frequency and severity of delirium, blood pressure, rescue experience, and infection were significant predictors of post-ICU cognitive impairment. Multivariate analysis results showed that the frequency and severity of delirium, and advanced age were risk factors of post-ICU cognitive impairment; high years of education and early active mobilisation were protective factors. CONCLUSIONS: Incidence of post-ICU cognitive impairment is at a high level, which is similar to former researches' results; the frequency and severity of delirium, and advanced age were risk factors of post-ICU cognitive impairment; high years of education and early active mobilisation were protective factors of post-ICU cognitive impairment.

5.
J Viral Hepat ; 2021 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-34218498

RESUMO

Several scores have been proposed in untreated or treated patients with chronic hepatitis B (CHB) to predict risks of hepatocellular carcinoma (HCC) occurrence. However, it is still unclear which score suits all chronic hepatitis B virus (HBV)-infected patients well, regardless of whether they are chronic carriers or CHB patients. In this study, we validated and compared the predictability of CU-HCC, REACH-B, PAGE-B and mPAGE-B in patients with chronic HBV infection in China. 1,786 patients with no history of HCC were recruited, with 978 carriers and 808 CHB patients on antiviral therapy. Patients were classified into low- and high-risk groups according to the predefined cut-off values of 5, 8, 10 and 9 for CU-HCC, REACH-B, PAGE-B and mPAGE-B. The median follow-up period was 43.7months, during which 18 (1.0%) patients developed HCC. The areas under the receiver operating characteristic curves (AUROCs) of CU-HCC, REACH-B, PAGE-B and mPAGE-B scores to predict HCC risk at 36 months were 0.815, 0.703, 0.794 and 0.825, respectively (all p < 0.05). No significant difference among AUROCs of these scores was observed except those of mPAGE-B and REACH-B at 36 months. The cumulative incidence of HCC in low- and high- risk groups based on CU-HCC, REACH-B, PAGE-B and mPAGE-B were 0.4% vs. 3.2%, 0.7% vs. 1.5%, 0.2% vs. 1.3%, and 0.2% vs. 1.7% at 36 months, respectively (all p < 0.05, except PAGE-B, log-rant test). Both CU-HCC and mPAGE-B scores accurately predict HCC risk in Chinese chronic HBV-infected patients. Patients with CU-HCC <5 or mPAGE-B <9 could be exempt from HCC surveillance within 36 months.

6.
J Agric Food Chem ; 69(28): 8017-8027, 2021 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-34236836

RESUMO

The aim of this study was to evaluate the effects of resistant starch (RS) and fat levels on the gut microbiome in C57BL/6 mice. Three levels of RS from three varieties of rice were the major source of carbohydrates and fat levels were low (10%) and high (39%). We confirmed that RS decreased the Firmicutes to Bacteroidetes ratio, increased SCFA production by higher Bacteroidaceae and S24-7 abundance, and enriched predicted gene families of glycosidases and functional pathways associated with carbohydrate and glycan metabolism. We also found correlations between microbial taxa and tissue gene expression related to carbohydrate and lipid metabolism. Moreover, increasing RS levels resulted in a molecular ecological network with enhanced modularity and interspecific synergy, which is less sensitive to high fat intervention. Overall, RS as low as 0.44% from cooked rice can modulate gut microbiome in mice, which correlated to a protective effect against deleterious effects of an obesogenic diet.


Assuntos
Microbioma Gastrointestinal , Oryza , Animais , Dieta Hiperlipídica , Intestinos , Camundongos , Camundongos Endogâmicos C57BL , Oryza/genética , Amido Resistente , Amido
7.
J Invest Dermatol ; 2021 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-34293353

RESUMO

Persistent chronic inflammation and delayed epithelialization lead to stalled healing in diabetic ulcers (DUs). PDL1 shows anti-inflammatory and proliferative activities in healing defects, while its function in DU pathogenesis remains unknown. Lower levels of PDL1 were found in DU tissues, and exogenous PDL1 has therapeutic effects in healing process by accelerating re-epithelialization and attenuating prolonged inflammation, which contributed to the delayed wound closure. We detected the downstream effectors of PDL1 using transcriptional profiles, and screened the interacting proteins by IP-MS and Co-IP assays. The biological functions of eIF3I-PDL1-IRS4 axis were tested both in vivo and in vitro. Finally, we validated the expression levels of eIF3I, PDL1, and IRS4 in DU tissues from human clinical samples by immunohistochemistry staining. Mechanistically, PDL1 binds to eIF3I and promotes cutaneous diabetic wound healing by downregulating IRS4. These findings identify the eIF3I-PDL1-IRS4 axis contributes to wound healing defects, which can serve as a potential therapeutic target in DUs.

8.
Brain Behav ; 2021 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-34291612

RESUMO

Recently, genome-editing technology like clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 has improved the translational gap in the treatments mediated through gene therapy. The advantages of the CRISPR system, such as, work in the living cells and tissues, candidate this technique for the employing in experiments and the therapy of central nervous system diseases. Parkinson's disease (PD) is a widespread, disabling, neurodegenerative disease induced by dopaminergic neuron loss and linked to progressive motor impairment. Pathophysiological basis knowledge of PD has modified the PD classification model and expresses in the sporadic and familial types. Analyses of the earliest genetic linkage have shown in PD the inclusion of synuclein alpha (SNCA) genomic duplication and SNCA mutations in the familial types of PD pathogenesis. This review analyzes the structure, development, and function in genome editing regulated through the CRISPR/Cas9. Also, it explains the genes associated with PD pathogenesis and the appropriate modifications to favor PD. This study follows the direction by understanding the PD linking analyses in which the CRISPR technique is applied. Finally, this study explains the limitations and future trends of CRISPR service in relation to the genome-editing process in PD patients' induced pluripotent stem cells.

9.
Insect Biochem Mol Biol ; 136: 103621, 2021 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-34233213

RESUMO

Mirid bugs are a group of important insect pests that cause large annual losses in agricultural production. Many studies have focused on the isolation and identification of sex pheromones in mirid bugs, and the components and biological activity of the sex pheromones have also been studied as a way to control these pests. However, few studies have focused on the mechanisms of pheromone perception. In this study, we identified the odorant receptor repertoire in three mirid bug species, Apolygus lucorum, Adelphocoris lineolatus, and Adelphocoris suturalis using antennal transcriptome sequencing and bioinformatics analysis. The candidate pheromone receptor (PR) genes were then identified by comparative transcriptomic and expression pattern analysis. Importantly, in vitro functional studies have shown that the candidate PRs have robust responses to the main mirid bug sex pheromone components (E)-2-hexenyl butyrate (E2HB) and hexyl butyrate (HB). Our study uncovered the mechanism of pheromone peripheral coding in these three species and elucidated the mechanism by which mirid bugs can specifically recognize a mate. Moreover, the results of our study will provide a theoretical basis for screening effective sex attractants or mating disturbance agents at the molecular and neural levels for enhanced control of these destructive pests.

10.
Molecules ; 26(13)2021 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-34202717

RESUMO

Timosaponin BII is one of the most abundant Anemarrhena saponins and is in a phase II clinical trial for the treatment of dementia. However, the pharmacological activity of timosaponin BII does not match its low bioavailability. In this study, we aimed to determine the effects of gut microbiota on timosaponin BII metabolism. We found that intestinal flora had a strong metabolic effect on timosaponin BII by HPLC-MS/MS. At the same time, seven potential metabolites (M1-M7) produced by rat intestinal flora were identified using HPLC/MS-Q-TOF. Among them, three structures identified are reported in gut microbiota for the first time. A comparison of rat liver homogenate and a rat liver microsome incubation system revealed that the metabolic behavior of timosaponin BII was unique to the gut microbiota system. Finally, a quantitative method for the three representative metabolites was established by HPLC-MS/MS, and the temporal relationship among the metabolites was initially clarified. In summary, it is suggested that the metabolic characteristics of gut microbiota may be an important indicator of the pharmacological activity of timosaponin BII, which can be applied to guide its application and clinical use in the future.


Assuntos
Microbioma Gastrointestinal/efeitos dos fármacos , Saponinas/farmacocinética , Esteroides/farmacocinética , Animais , Biotransformação , Masculino , Ratos , Ratos Sprague-Dawley , Saponinas/farmacologia , Esteroides/farmacologia
11.
J Sci Food Agric ; 2021 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-34302360

RESUMO

BACKGROUND: The waste of salted egg white resources has always been a serious problem in food industry. Herein, in this current study, we reported a kind of Pickering emulsion systems, which was stabilized by duck egg white nanogels (DEWN) and sodium alginate (SA), followed by which this system was cross-linked by calcium carbonate (CaCO3 ) via controlling the gluconolactone (GDL) concentrations, aiming to open up a promising route for making full use of these protein resources. RESULTS: The droplet sizes of the emulsion exhibited a reduction with an increase in SA concentrations, indicating that higher negative charges and steric hindrance was useful for a stable emulsion system. Meanwhile, the result of rheology measurement showed that G' values were higher than G" values of the samples at higher GDL concentration, revealing the formation of elastic gel-like networks in the systems, which was fabricated by SA and Ca2+ released by the CaCO3 particles. The gel-like network structure in the continuous phase improved both the freeze-thaw and thermal stability of the obtained Pickering emulsions system. Encouragingly, the Pickering high internal phase emulsions (HIPEs, φ = 0.75) stabilized by DEWN/SA3 -GDL3 were prepared, which could be stored at 4 °C for at least 30 days without oiling-off and creaming. CONCLUSION: These findings not only develop a green ultra-stable Pickering emulsions system but also extend the potential commercial applications of duck egg white proteins in food, cosmetics, and pharmaceutical industry. This article is protected by copyright. All rights reserved.

12.
J Sci Food Agric ; 2021 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-34302364

RESUMO

BACKGROUND: Free fractions of different blackberry varieties extracts are high in phenolic compounds with antioxidant activities. However, the phenolic profiles and antioxidant activities against peroxyl radicals of bound fractions of different blackberry varieties extracts have not been previously reported. In addition, what are the key antioxidant phenolic compounds in free and bound fractions of blackberry extracts remain unknown. The present study aimed to investigate the phenolic profiles and antioxidant activities of free and bound fractions of eight blackberry varieties extracts and reveal the key antioxidant phenolic compounds by boosted regression trees. RESULTS: Fifteen phenolics (three anthocyanins, four flavonols, three phenolic acids, two proanthocyanidins, and three ellagitannins) were identified in blackberry by UPLC-Q-TOF-MS. Ferulic acid, ellagic acid, procyanidin C1, kaempferol-O-hexoside, ellagitannins hex, and gallic acid were major bound phenolics. Bound fractions of eight blackberry varieties extracts were high in phenolics and showed great antioxidant activity. Boosted regression trees analysis showed that cyanidin-3-O-glucoside and chlorogenic acid were the most significant compounds, contributing 48.4% and 15.9% to the antioxidant activity of free fraction, respectively. Ferulic acid was the most significant antioxidant compound in bound fraction with a contribution of 61.5%. Principal component analysis showed that Kiowa was the best among the eight varieties due to its phenolic profile and antioxidant activity. CONCLUSION: It was concluded that blackberry varieties contained high amounts of bound phenolics, which confer health benefits through reducing oxidative stress. Ferulic acid was key compound to explain the antioxidant activities of bound fractions. This article is protected by copyright. All rights reserved.

13.
J Cell Mol Med ; 2021 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-34302427

RESUMO

High myopia is one of the leading causes of visual impairment worldwide with high heritability. We have previously identified the genetic contribution of SLC39A5 to nonsyndromic high myopia and demonstrated that disease-related mutations of SLC39A5 dysregulate the TGF-ß pathway. In this study, the mechanisms underlying SLC39A5 involvement in the pathogenesis of high myopia are determined. We observed the morphogenesis and migration abnormalities of the SLC39A5 knockout (KO) human embryonic kidney cells (HEK293) and found a significant injury of ECM constituents. RNA-seq and qRT-PCR revealed the transcription decrease in COL1A1, COL2A1, COL4A1, FN1 and LAMA1 in the KO cells. Further, we demonstrated that TGF-ß signalling, the regulator of ECM, was inhibited in SLC39A5 depletion situation, wherein the activation of receptor Smads (R-Smads) via phosphorylation was greatly blocked. SLC39A5 re-expression reversed the phenotype of TGF-ß signalling and ECM synthesis in the KO cells. The fact that TGF-ß signalling was zinc-regulated and that SLC39A5 was identified as a zinc transporter urged us to check the involvement of intracellular zinc in TGF-ß signalling impairment. Finally, we determined that insufficient zinc chelation destabilized Smad proteins, which naturally inhibited TGF-ß signalling. Overall, the SLC39A5 depletion-induced zinc deficiency destabilized Smad proteins, which inhibited the TGF-ß signalling and downstream ECM synthesis, thus contributing to the pathogenesis of high myopia. This discovery provides a deep insight into myopic development.

14.
ACS Nano ; 2021 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-34313425

RESUMO

Personal protective equipment (PPE) is vital for the prevention and control of SARS-CoV-2. However, conventional PPEs lack virucidal capabilities and arbitrarily discarding used PPEs may cause a high risk for cross-contamination and environmental pollution. Recently reported photothermal or photodynamic-mediated self-sterilizing masks show bactericidal-virucidal abilities but have some inherent disadvantages, such as generating unbearable heat during the photothermal process or requiring additional ultraviolet light irradiation to inactivate pathogens, which limit their practical applications. Here, we report the fabrication of a series of fabrics (derived from various PPEs) with real-time self-antiviral capabilities, on the basis of a highly efficient aggregation-induced emission photosensitizer (namely, ASCP-TPA). ASCP-TPA possesses facile synthesis, excellent biocompatibility, and extremely high reactive oxygen species generation capacity, which significantly outperforms the traditional photosensitizers. Meanwhile, the ASCP-TPA-attached fabrics (ATaFs) show tremendous photodynamic inactivation effects against MHV-A59, a surrogate coronavirus of SARS-CoV-2. Upon ultralow-power white light irradiation (3.0 mW cm-2), >99.999% virions (5 log) on the ATaFs are eliminated within 10 min. Such ultralow-power requirement and rapid virus-killing ability enable ATaFs-based PPEs to provide real-time protection for the wearers under indoor light irradiation. ATaFs' virucidal abilities are retained after 100 washings or continuous exposure to office light for 2 weeks, which offers the benefits of reusability and long-term usability. Furthermore, ATaFs show no toxicity to normal skin, even upon continuous high-power light illumination. This self-antiviral ATaFs-based strategy may also be applied to fight against other airborne pathogens and holds huge potential to alleviate global PPE supply shortages.

15.
Environ Pollut ; 288: 117785, 2021 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-34273764

RESUMO

Arsenic (As) accumulation catastrophically disturbs the stability of agricultural systems and human health. Rice easily accumulates a high amount of As from agriculture fields as compare with other cereal crops. Hence, innovative soil remediation methods are needed to deal with the detrimental effects of As on human health causing food security challenges. Here, we report the green synthesis and characterization of magnesium oxide nanoparticles (MgO-NPs) from a native Enterobacter sp. strain RTN2, which was genetically identified through 16S rRNA gene sequence analysis. The biosynthesis of MgO-NPs in reaction mixture was confirmed by UV-vis spectral analysis. X-ray diffraction (XRD) and fourier transform-infrared spectroscopy (FTIR) analysis showed the crystalline nature and surface properties of MgO-NPs, respectively. Moreover, electron microscopy (SEM-EDS, and TEM) imaging confirmed the synthesis of spherical shape of MgO-NPs with variable NPs sizes ranging from 38 to 57 nm. The results revealed that application of MgO-NPs (200 mg kg-1) in As contaminated soil significantly increased the plant biomass, antioxidant enzymatic contents, and decreased reactive oxygen species and acropetal As translocation as compared with control treatment. The study concluded that biogenic MgO-NPs could be used to formulate a potent nanofertilizer for sustainable rice production in metal contaminated soils.

16.
Toxins (Basel) ; 13(7)2021 06 30.
Artigo em Inglês | MEDLINE | ID: mdl-34209281

RESUMO

Epithelial ovarian cancer (EOC) is a fatal gynecologic cancer, and its poor prognosis is mainly due to delayed diagnosis. Therefore, biomarker identification and prognosis prediction are crucial in EOC. Altered cell metabolism is a characteristic feature of cancers, and metabolomics reflects an individual's current phenotype. In particular, plasma metabolome analyses can be useful for biomarker identification. In this study, we analyzed 624 metabolites, including uremic toxins (UTx) in plasma derived from 80 patients with EOC using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Compared with the healthy control, we detected 77 significantly increased metabolites and 114 significantly decreased metabolites in EOC patients. Especially, decreased concentrations of lysophosphatidylcholines and phosphatidylcholines and increased concentrations of triglycerides were observed, indicating a metabolic profile characteristic of EOC patients. After calculating the parameters of each metabolic index, we found that higher ratios of kynurenine to tryptophan correlates with worse prognosis in EOC patients. Kynurenine, one of the UTx, can affect the prognosis of EOC. Our results demonstrated that plasma metabolome analysis is useful not only for the diagnosis of EOC, but also for predicting prognosis with the variation of UTx and evaluating response to chemotherapy.

17.
Cancer Lett ; 518: 140-151, 2021 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-34274452

RESUMO

The activating transcription factor 1 (ATF1) has been identified as a vital pathogenic factor in the progression of colorectal cancer (CRC), whiles, the precise regulatory mechanisms remain elusive. Here, we comprehensively characterized the ATF1 cistrome by RNA-seq and ChIP-seq assays in CRC cell lines. As the results, we identified 358 genes differentially regulated and 15,029 ATF1 binding sites and demonstrated that ATF1 was widely involved in major signaling pathways in CRC, such as Wnt, TNF, Jak-STAT. Subsequently, by the expression quantitative trait loci (eQTL) analyses, we found that rs7017386 was associated with the expression of CCAT1 and PVT1 in the Wnt pathway. By a two-stage population study with 6,131 CRC cases and 10,022 healthy controls, we identified the variant was associated with CRC risk. Mechanistically, we found rs7017386 allele-specifically enhanced the binding affinity of ATF1 and promoted the expressions of PVT1 and CCAT1, via forming a long-range chromatin loop. Moreover, those two lncRNAs could synergistically facilitate c-Myc expression to activate the Wnt pathway in CRC progression. Our findings not only demonstrated the transcriptomic profiling of ATF1 in CRC, but also provided important clues for the etiology of CRC.

18.
Comput Intell Neurosci ; 2021: 3846078, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34306052

RESUMO

The booming computational thinking and deep learning make it possible to construct agile, efficient, and robust deep learning-driven decision-making support engine for the operation of container terminal handling systems (CTHSs). Within the conceptual framework of computational logistics, an attention mechanism oriented hybrid convolutional neural network and recurrent neural network deep learning architecture (AMO-HCR-DLA) is proposed technically to predict the container terminal liner handling conditions that mainly include liner handling time (LHT) and total working time of quay crane farm (TWT-QCF) for a calling liner. Consequently, the container terminal oriented logistics generalized computation (CTO-LGC) automation and intelligence are established tentatively by AMO-HCR-DLA. A typical regional container terminal hub of China is selected to design, implement, execute, and evaluate the AMO-HCR-DLA with the actual production data. In the case of severe vibration of LHT and TWT-QCF, while forecasting the handling conditions of 210 ships based on the CTO-LGC running log of four years, the forecasting error of LHT within one hour is more than 97% and that of TWT-QCF within six hours accounts for 89.405%. When predicting the operating conditions of 300 liners by the log of five years, the forecasting deviation of LHT within one hour is more than striking 99% and that of TWT-QCF within six hours reaches up to 94.010% as well. All are far superior to the predicting outcomes by the classical algorithms of machine learning and deep learning. Hence, the AMO-HCR-DLA shows excellent performance for the prediction of CTHS with the low and stable computational consuming. It also demonstrates the feasibility, credibility, and realizability of the computing architecture and design paradigm of AMO-HCR-DLA preliminarily.


Assuntos
Aprendizado Profundo , Algoritmos , China , Aprendizado de Máquina , Redes Neurais de Computação
19.
J Colloid Interface Sci ; 605: 129-137, 2021 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-34311307

RESUMO

Lithium-sulfur (Li-S) batteries are greatly expected to be the favored alternatives in the next-generation energy-storage technologies due to their exceptional advantages. However, the shuttle effect and sluggish reaction kinetics of polysulfides largely hamper the practical success of Li-S batteries. Herein, a unique iron carbide (Fe3C) nanoparticles-embedded porous biomass-derived carbon (Fe3C-PBC) is reported as the excellent immobilizer and promoter for polysulfides regulation. Such a distinctive composite strongly couples the vast active sites of Fe3C nanoparticles and the conductive network of porous biomass-derived carbon. Therefore, Fe3C-PBC is endowed with outstanding adsorptivity and catalytic effect toward inhibiting the shuttle effect and facilitating the redox kinetics of polysulfides, demonstrated by the detailed experimental demonstrations and theoretical calculation. With these synergistic effects, the Fe3C-PBC/S electrode embraces a superb capacity retention of 82.7% at 2C over 500 cycles and an excellent areal capacity of 4.81 mAh cm-2 under the high-sulfur loading of 5.2 mg cm-2. This work will inspire the design of advanced hosts based on biomass materials for polysulfides regulation in pursuing the superior Li-S batteries.

20.
Mil Med Res ; 8(1): 39, 2021 07 02.
Artigo em Inglês | MEDLINE | ID: mdl-34210357

RESUMO

BACKGROUND: Pituicytoma is an extremely rare low-grade glial tumor that is closely related to the neurohypophysis axis. Most studies of pituicytomas include only several cases. To better understand this disease, we reviewed a series of cases of pituicytomas. The diagnosis and treatment of pituicytoma must be further elucidated. METHODS: Eleven patients with pituicytoma admitted to Beijing Tiantan Hospital from 2012 to 2019 were selected. The clinical features, including radiological and histological examination, surgical records and prognosis were reviewed. Sixty-eight other previously published cases of pituicytoma also were used to analyze the predictive factors for the results. The Cox regression model was used for univariate and multivariate analyses. RESULTS: Our patients included 5 males (45.5%) and 6 females (54.5%), with a mean age of 49.3 years. The tumor was located in the suprasellar region in 5 patients (45.5%), intrasellar region in 4 patients (36.4%), and intrasellar-suprasellar region in 2 patients (18.2%). All patients were misdiagnosed with other common tumors in the sellar region before the operation. During the operation, gross total resection (GTR) of the tumor was achieved in 6 patients (54.5%), and subtotal resection (STR) was achieved in 5 patients (45.5%). The mean progression-free survival (PFS) time was 29.82 months. Tumor progression after surgical resection occurred in 4 patients (36.4%). Among them, 60.0% of the patients (cases 4, 5, 7) with STR experienced progression, while 16.7% of the patients (case 2) with GTR experienced progression. Combined with the 68 cases in the literature, GTR was an independent risk factor for PFS time (P < 0.05). CONCLUSIONS: Pituicytomas are more common in middle-aged people and the sellar region. The clinical manifestations of pituicytomas are different, but no diagnostic clinical features have been identified other than an abnormally abundant blood supply. Currently, GTR is the best approach for the treatment of pituicytomas. More patients and longer follow-up periods were needed to further elucidate the biological features of pituicytomas.

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