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1.
Autops. Case Rep ; 9(4): e2019117, Oct.-Dec. 2019. ilus
Artigo em Inglês | LILACS | ID: biblio-1024240

RESUMO

Sporadic Burkitt lymphoma (SBL) is a variant of Burkitt lymphoma that occurs worldwide, affecting mainly children and young adults. Association with Epstein-Barr virus (EBV) can be identified in approximately 20-30% of cases. Herein we described a case of a 63-year-old male presenting intraoral bilateral mandibular swelling, subjacent to fixed dental prosthesis, with one month of duration. Incisional biopsies were performed, and after two days, the patient was hospitalized due to malaise and breathing difficulty, and died after a week when an abdominal tumor was detected. The mandibular biopsies revealed a diffuse proliferation of medium-sized monomorphic atypical lymphoid cells exhibiting numerous mitoses and areas of "starry-sky" pattern. The tumor showed immunohistochemical positivity for CD20, CD10, Bcl-6, and Ki-67 (≈ 100%); it was negative for CD3, Bcl-2, Vs38c, and MUM-1. Positivity for EBV was found by in situ hybridization. The final diagnosis was intraoral SBL positive for EBV. Clinical, morphological and molecular criteria are necessary for the correct diagnosis of aggressive B-cell neoplasms positive for EBV in elderly patients.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/patologia , Linfoma de Burkitt/patologia , Herpesvirus Humano 4 , Linfoma não Hodgkin/patologia
2.
Trop Doct ; 49(4): 303-306, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31156067

RESUMO

Diffuse cutaneous leishmaniasis is a rare chronic infectious disease, associated with Leishmania mexicana and L. amazonensis, presenting as multiple non-ulcerative painless nodules, with a tendency to relapse soon after treatment. We report a case of a 56-year-old Mexican woman exhibiting nodular lesions, plaques, crusts and scars involving the whole body. A solitary nodule was present at the junction between hard and soft palates. Diffuse cutaneous leishmaniasis is a disfiguring disease resulting in severe scarring if untreated.


Assuntos
Leishmania mexicana/fisiologia , Leishmaniose Tegumentar Difusa/complicações , Leishmaniose Tegumentar Difusa/diagnóstico , Doenças da Boca/etiologia , Doenças da Boca/parasitologia , Palato/patologia , Feminino , Humanos , Leishmaniose Tegumentar Difusa/parasitologia , Leishmaniose Tegumentar Difusa/patologia , México , Pessoa de Meia-Idade , Palato/parasitologia , Recidiva
3.
Int J Surg Pathol ; 26(8): 758-765, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29890883

RESUMO

Calcifying odontogenic cyst (COC) is a rare odontogenic cyst with ameloblastic epithelial lining containing clusters of ghost cells. COCs have been described in association with several odontogenic tumors, more commonly odontomas and rarely with dentigerous cyst (DC). In this article, we describe a case of COC associated with DC in a 15-year-old girl, who presented with a swelling on the right middle third of the face, producing facial asymmetry. Panoramic radiography showed a well-circumscribed, corticated, and unilocular radiolucency at the level of the right maxillary sinus, involving 2 unerupted premolars. The lesion was enucleated and histologically revealed a COC associated with DC, which presented mucous metaplasia. Immunohistochemical reactions were performed to better illustrate this rare synchronous occurrence of COC and DC, showing positivity for CK5, CK14, CK19, and p63 in both lesions. CK18 was negative in COC, and Bcl-2 was negative in DC. Periodic acid Schiff highlighted the mucous cells in the DC lining.


Assuntos
Biomarcadores Tumorais/análise , Cisto Dentígero/complicações , Neoplasias Maxilares/patologia , Cisto Odontogênico Calcificante/patologia , Adolescente , Cisto Dentígero/diagnóstico por imagem , Cisto Dentígero/cirurgia , Feminino , Humanos , Maxila/diagnóstico por imagem , Maxila/patologia , Maxila/cirurgia , Neoplasias Maxilares/diagnóstico , Neoplasias Maxilares/etiologia , Neoplasias Maxilares/cirurgia , Cisto Odontogênico Calcificante/diagnóstico , Cisto Odontogênico Calcificante/etiologia , Cisto Odontogênico Calcificante/cirurgia , Radiografia Panorâmica , Tomografia Computadorizada por Raios X
4.
J Clin Exp Dent ; 9(12): e1487-e1491, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29410767

RESUMO

The antimalarials are one of the most commonly prescribed drugs for conditions such as lupus erythematosus and rheumatoid arthritis, and the side effects, though infrequent, are well known. The antimalarial agent chloroquine diphosphate usually causes pigmentary changes in the oral mucosa characterized by a bluish-grey to black discolorations mainly in the hard palate. Considering only the hard palate hyperpigmentation caused by chloroquine, to the best of our knowledge, only 13 cases have been reported in the English language literature. We described an additional case of palate hyperpigmentation related to the chronic use of chloroquine diphosphate in a 60-year-old Mexican woman. Although the diagnosis is usually made based on medication history and clinical presentation, a biopsy specimen may be helpful to confirm the diagnosis. Clinicians must be aware of these drugs and their adverse effects in order to make the correct diagnosis and decide on the optimal treatment for the condition. Key words:Oral cavity, hard palate, hyperpigmentation, chloroquine, antimalarials.

5.
Int J Dent ; 2012: 628406, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22927853

RESUMO

Throughout life, bone tissue undergoes a continuous process of resorption and formation. Melatonin, with its antioxidant properties and its ability to detoxify free radicals, as suggested by Conconi et al. (2000) may interfere in the osteoclast function and thereby inhibit bone resorption, as suggested by Schroeder et al. (1981). Inhibition of bone resorption may be enhanced by a reaction of indoleamine in osteoclastogenesis. That it has been observed melatonin, at pharmacological doses, decrease bone mass resorption by suppressing through down regulation of the RANK-L, as suggested by Penarrocha Diago et al. (2005) and Steflik et al. (1994). These data point an osteogenic effect towards that may be of melatonin of clinical importance, as it could be used as a therapeutic agent in situations in which would be advantageous bone formation, such as in the treatment of fractures or osteoporosis or their use as, a bioactive surface on implant as suggested by Lissoni et al. (1991).

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