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1.
Vestn Oftalmol ; 135(5): 85-91, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31714518

RESUMO

The article offers a review of mitochondrial biogenesis in hereditary optic neuropathies. It covers the mechanisms of mitochondrial biogenesis, factors affecting it and tools for mitochondrial turnover assessment.


Assuntos
Doenças do Nervo Óptico , DNA Mitocondrial , Humanos , Biogênese de Organelas , Células Ganglionares da Retina
2.
Zootaxa ; 4623(2): zootaxa.4623.2.8, 2019 Jun 25.
Artigo em Inglês | MEDLINE | ID: mdl-31716265

RESUMO

The Moluccan net-winged beetle fauna remains poorly studied and here, new species of Schizotrichalus Kleine, 1926 and Eniclases Waterhouse, 1879 are reported from Halmahera. Using morphological traits and cox1 mitochondrial DNA sequences, we propose two new species, Eniclases kusyi sp. nov. and Schizotrichalus halmaherensis sp. nov., and redescribe E. moluccanus Kleine, 1930. New molecular data confirm morphology-based sister relationships between Schizotrichalus and Eniclases and the analysis identifies the combined area of the present-day Halmahera and New Guinea as an ancestral area of these genera. Now, Halmahera and New Guinea are quite similar in respect of the number of trichaline genera. Concerning the size of islands and the recent origin of the nowadays northern Moluccas, these results are unexpected and thus the general validity of this distribution pattern should be confirmed with other groups of beetles.


Assuntos
Besouros , Animais , Ciclo-Oxigenase 1 , DNA Mitocondrial , Nova Guiné , Filogenia
3.
Zootaxa ; 4609(3): zootaxa.4609.3.2, 2019 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-31717092

RESUMO

Woodland salamanders of the genus Plethodon are characterized by strong ecological and morphological conservatism. One assemblage, the Wehrle's salamander (Plethodon wehrlei Fowler Dunn) species group, is distributed from New York to Tennessee, USA, and includes several morphological variants, four of which are sufficiently distinct to have been recognized as species in the past. For many years after two of these species were placed in synonymy, only P. wehrlei and P. punctatus Highton were recognized. A recent phylogeographic study using mitochondrial DNA and nuclear DNA uncovered considerable genetic diversity within the group and conservatively resurrected one of the previously synonymized forms (P. dixi Pope Fowler). However, their analysis could not resolve all relationships among remaining populations of P. wehrlei, leaving the taxon paraphyletic. We re-evaluated the evolutionary history of this group using genomic data, recovered strong support for at least five distinct clades, and corroborated previously reported relationships. We also collected morphological data and demonstrated morphological distinctiveness for four of the five clades that we herein recognize as species. We resurrect the synonymized name P. jacksoni Newman to represent the southern clades of P. wehrlei in southwestern Virginia and North Carolina exclusive of P. dixi. In addition, we describe a yellow-spotted form of P. wehrlei endemic to the Cumberland Plateau as a new species. Although our proposed changes rectify the paraphyly of P. wehrlei, our sampling was not sufficient to resolve potential taxonomic issues remaining within the species herein recognized as P. jacksoni.


Assuntos
DNA Mitocondrial , Urodelos , Animais , Genômica , New York , North Carolina , Filogenia , Análise de Sequência de DNA , Tennessee , Virginia
4.
Zootaxa ; 4609(3): zootaxa.4609.3.8, 2019 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-31717098

RESUMO

Mountain chains and rivers are often found to represent barriers promoting vicariant differentiation in terrestrial vertebrates. Previous studies have supported the idea that the Cordillera de Mérida (CM), the easternmost branch of the Northern Andes, represents a geographic barrier for vertebrates, including frogs. Previous studies have also suggested that the Orinoco River (OR), the biggest river in Venezuela, also represents a geographic barrier for terrestrial vertebrates. Boana pugnax and B. xerophylla are two Neotropical hylids, members of the B. faber species group, that are distributed on either side of the CM, and whose ranges extend up to 605 and 2450 m in elevation, respectively. In addition, B. xerophylla occurs on either side of the OR. Herein, we assess the genetic, acoustic, and morphological differentiation within B. pugnax and within B. xerophylla across the CM and within B. xerophylla across the OR, and test if genetic differentiation is correlated with geographic distance. We also evaluated the acoustic differentiation between the recently recognized B. xerophylla and its sister species, B. crepitans, and found marked differences between advertisement calls, corroborating their status as distinct species. Genetic and morphometric analyses of populations from opposite sides of the CM revealed differentiation in B. pugnax but not in B. xerophylla. Within the latter species, we found molecular, acoustic, and morphometric differentiation among samples of B. xerophylla from western Venezuela versus the Guiana Shield. Genetic variation within B. pugnax and within B. xerophylla was not explained by geographic distance. Thus, our data show conspecific population structure across the CM in B. pugnax, plus the possible existence of two species within what today is considered B. xerophylla, yet the CM apparently is not involved in this divergence. These results suggest that even for closely related species with shared ecology and distribution, genetic and phenotypic differentiation respond differently to common ecological or historical factors.


Assuntos
Anuros , Deriva Genética , Acústica , Animais , DNA Mitocondrial , Variação Genética , Filogenia , Filogeografia , Rios , Venezuela
5.
Zootaxa ; 4642(1): zootaxa.4642.1.1, 2019 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-31712451

RESUMO

Phylogenetic relationships of snailfishes of the family Liparidae were analyzed on the basis of two sets of molecular sequence data: one from the mitochondrial DNA cytochrome c oxidase subunit one gene (COI) and another from restriction-site associated genome-wide sequences (RADseq). The analysis of COI sequence data from at least 122 species of 18 genera from the Pacific, Atlantic, and Southern oceans resulted in a moderately well-resolved phylogeny among the major clades, albeit with significant polytomy among central clades. Nectoliparis was the sister of all other members of the family, followed by Liparis. Liparis, Careproctus, and Paraliparis were paraphyletic. Liparis was recovered in two closely related clades, with L. fucensis sister of all other liparids except Nectoliparis, and both Careproctus and Paraliparis were each recovered among at least three widely separated clades. The RADseq analysis of 26 species of 11 genera from the eastern North Pacific strongly confirmed the overall results of the COI analysis, with the exception of the paraphyly of Liparis due to the absence of L. fucensis. Our results show that the pelvic disc has been independently lost multiple times and the pectoral-fin girdle has been independently reduced in multiple lineages.


Assuntos
DNA Mitocondrial , Genômica , Perciformes , Animais , Sequência de Bases , Perciformes/genética , Filogenia , Análise de Sequência de DNA
6.
Zootaxa ; 4638(4): zootaxa.4638.4.7, 2019 Jul 18.
Artigo em Inglês | MEDLINE | ID: mdl-31712462

RESUMO

Paraschistura kermanensis from the endorheic Kerman-Naein basin in Iran is distinguished from its closest congeners (P. abdolii, P. delvarii, P. kessleri and P. naumanni) by lacking scales on the flanks anterior to the dorsal-fin origin, having scales on the caudal peduncle, and having the pelvic-fin origin situated anterior to or below the vertical through the dorsal-fin origin. It is also characterised by six fixed diagnostic nucleotide substitutions and a K2P nearest neighbour distance of 4% to P. abdolii in the mtDNA COI barcode region.


Assuntos
Cipriniformes , Animais , DNA Mitocondrial , Irã (Geográfico) , Rios
7.
Zootaxa ; 4590(4): zootaxa.4590.4.3, 2019 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-31716081

RESUMO

Deep-sea shrimps of the species Plesionika acanthonotus (Smith, 1882) and P. holthuisi Crosnier Forest, 1968 are morphologically similar and exhibit overlapping amphi-Atlantic distributions. In the literature, through morphological studies, there are reports of doubts about the validity of P. holthuisi and some authors believe that the eastern and western Atlantic populations of P. acanthonothus could represent two distinct species. The objective of the present study was to use molecular data to elucidate the taxonomic status of the two populations of P. acanthonothus. DNA sequences of two mitochondrial genes (16S rDNA and Cytochrome Oxidase subunit I) and a nuclear gene (Histone 3) were obtained for both species and for both populations of P. acanthonotus. The sequences were also obtained from Genbank for comparison. The trees (separate and multi-locus/partitioned genes) were generated by Bayesian Inference analyzes, and genetic divergence (Kimura-2-parameters) was also calculated. All specimens that had their DNA sequenced were examined morphologically to confirm their identification; morphological variations were noted. The genetic data showed that Plesionika holthuisi is closely related to P. acanthonotus, but clearly separated, indicating that P. holthuisi is a valid species. In the multi-locus analysis, the P. acanthonothus specimens were divided into two clades, one with the eastern Atlantic specimens and another with the western Atlantic specimens. However, this genetic separation was considered to be a population structuring for three reasons: (1) the genetic divergences of the two mitochondrial genes between these two groups (eastern Atlantic X western Atlantic) were smaller than the interspecific divergence for Plesionika; (2) the P. acanthonothus sequences of the Histone 3 gene showed no genetic variation; (3) in the analyzed individuals, no valid morphological character was found to support this separation. Thus, the conclusion of this study is that P. holthuisi probably is a valid species and P. acanthonothus presents two populations with mitochondrial divergences that could be in the process of speciation, but which currently represent only one species.


Assuntos
Decápodes (Crustáceos) , Pandalidae , Animais , Teorema de Bayes , DNA Mitocondrial , DNA Ribossômico , Filogenia
8.
Zootaxa ; 4664(1): zootaxa.4664.1.6, 2019 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-31716691

RESUMO

Charinus rocamadre is the only species described and recorded from Colombia. It is know from only one male specimen collected from a cave in the Colombian Caribbean region. Herein, we describe the female of C. rocamadre for the first time, based on several specimens collected from the type locality of this species. We also provide images and describe the ultrastructure of male and female gonopods, as well as provide partial sequences of two mitochondrial genes (COI and 16S rRNA).


Assuntos
Aracnídeos , DNA Mitocondrial , Animais , Região do Caribe , Colômbia , Feminino , Masculino , Filogenia , RNA Ribossômico 16S
9.
Zootaxa ; 4567(3): zootaxa.4567.3.3, 2019 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-31715883

RESUMO

Until recently, almost all barbastelle populations inhabiting Asia, from Iran to Japan and Taiwan, were recognized as a single species, Barbastella darjelingensis. However, in recent years, it was shown that the taxonomic diversity within the genus Barbastella was underestimated, and B. darjelingensis sensu lato is highly variable, both morphologically and genetically. Transcaucasian and Central Asian populations were already raised to the species level as B. caspica. Populations from eastern and south-eastern Asia are still understudied and likely encompass undescribed species. Comparing results from mtDNA sequences, skull morphometry and baculum shape, we concluded that one of these putative species is represented by populations inhabiting Honshu, Hokkaido and Kunashir Islands, and provide a scientific description of this new species. Populations from Taiwan, southern China and Indochina represent a sister mitochondrial clade to this new species. However, available morphological material from these areas did not demonstrate a significant difference from the Himalayan B. darjelingensis. Therefore, we refuse to give this form any taxonomic status until further studies of more vast material are done.


Assuntos
Quirópteros , Animais , DNA Mitocondrial , Ilhas , Japão , Filogenia
10.
Zootaxa ; 4674(3): zootaxa.4674.3.7, 2019 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-31716006

RESUMO

The aim of this study is to assess the species status of the Middle-European Thanasimus Latreille, 1806 species using mitochondrial CO1 sequence data. Molecular biological results clearly support the synonymy of T. pectoralis (Fuss, 1863) and T. rufipes (Brahm, 1797) with T. femoralis (Zetterstedt, 1828) as already proposed by Kolibác (1992). Results of the present study indicate high genetic variation within T. formicarius (Linné, 1758) and emphasize the study of population dynamics of T. formicarius within Europe. Furthermore, preliminary screening of all available T. formicarius sequences on BOLD and Genbank (shorter than 500bp) indicates the presence of a "Continental" and a more "Atlantic" clade in T. formicarius. To support our hypothesis of a probably cryptic species among T. formicarius, more studies, with more specimens from different populations, especially from southern England, northern France and the northern part of the Iberian Peninsula, will be necessary.


Assuntos
Besouros , DNA Mitocondrial , Variação Genética , Animais , Besouros/genética , Inglaterra , Europa (Continente) , França , Haplótipos , Filogenia , Análise de Sequência de DNA
11.
Zootaxa ; 4671(2): zootaxa.4671.2.3, 2019 Sep 17.
Artigo em Inglês | MEDLINE | ID: mdl-31716054

RESUMO

Garra roseae, new species, is described from the stream Tang-e-Sarhe in the Iranian Makran region. It is distinguished from its congeners in the Middle East by lacking barbels, having a small mental disc, 42-58 total scales along the lateral line, 24-30 scales along the predorsal midline, and 20-24 circumpeduncular scales. It is further characterised by having five diagnostic nucleotide substitutions and a minimum K2P distance of 5.39% to G. rossica and 5.49% to G. nudiventris in the mtDNA COI barcode region. Garra phryne from eastern Iran is considered to be a synonym of G. nudiventris.


Assuntos
Cyprinidae , Animais , DNA Mitocondrial , Irã (Geográfico) , Oriente Médio , Rios
12.
Zootaxa ; 4619(1): zootaxa.4619.1.6, 2019 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-31716318

RESUMO

Species delimitation attempts to match species-level taxonomy with actual evolutionary lineages. Such taxonomic conclusions are typically, but not always, based on patterns of congruence across multiple data sources and methods of analyses. Here, we use this pluralistic approach to species delimitation to help resolve uncertainty in species boundaries of phrynosomatid sand lizards of the genus Holbrookia. Specifically, the Spot-tailed Earless Lizard (H. lacerata) was historically divided into a northern (H. l. lacerata) and southern (H. l. subcaudalis) subspecies based on differences in morphology and allopatry, but no research has been conducted evaluating genetic differences between these taxa. In this study, patterns in sequence data derived from two genes, one nuclear and one mitochondrial, for 66 individuals sampled across 18 counties in Texas revealed three strongly supported, reciprocally monophyletic lineages, each comprised of individuals from a single geographic region. Distinct genetic variation evident across two of these regions corresponds with differences in morphology, differences in environmental niche, and lines up with the presumed geographic barrier, the Balcones Escarpment, which is the historical subspecies boundary. The combined evidence from genetics, morphology and environmental niche is sufficient to consider these subspecies as distinct species with the lizards north of the Balcones Escarpment retaining the name Holbrookia lacerata, and those south of the Balcones Escarpment being designated as Holbrookia subcaudalis.


Assuntos
Lagartos , Animais , Evolução Biológica , DNA Mitocondrial , Mitocôndrias , Filogenia , Texas
13.
Zootaxa ; 4614(1): zootaxa.4614.1.5, 2019 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-31716389

RESUMO

Alburnoides holciki was described from the Hari River basin, which was the only basin it was known from. Populations from the Amu Darya basin were previously recognized as A. eichwaldii or Alburnoides sp. Our study recognized specimens of Alburnoides from the Amu Darya basin as A. holciki based on morphological data and the COI barcode gene. The population from the Zeravshan basin showed some morphological differences compared to others but were similar in the COI gene and needs further investigation. New results extend the range of A. holciki for almost 1000 km -from the Hari River to the upper Amu Darya tributaries in Tajikistan. The intraspecific genetic similarity in the COI gene between populations in the Hari and Amu Darya rivers supports the geographical hypothesis of a recent connection of these rivers.


Assuntos
Cyprinidae , DNA Mitocondrial , Animais , Ásia Central , Rios , Tadjiquistão
14.
Zootaxa ; 4671(1): zootaxa.4671.1.8, 2019 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-31716597

RESUMO

Pseudophoxinus cilicicus, new species, is described from the Arsuz, Ceyhan and Seyhan river drainages in the Gulf of Iskenderun. It is distinguished from other members of the Pseudophoxinus zeregi species group by having a complete lateral line with 38-45 + 2-3 scales, the lower lip usually slightly projecting beyond the tip of the upper lip, a prominent black stripe along the flank, and no black pigments below the lateral line. Pseudophoxinus cilicicus is distinguished from P. zekayi by a minimum K2P distance of 3.8% based on the mitochondrial DNA barcode region. Pseudophoxinus atropatenus and P. sojuchbulagi are returned to the genus Rutilus.


Assuntos
Cyprinidae , Animais , Cor , DNA Mitocondrial , Rios , Estações do Ano
15.
Zootaxa ; 4661(3): zootaxa.4661.3.4, 2019 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-31716698

RESUMO

The recent report of Nemoura lacustris Pictet, 1865 in Great Britain has raised doubts on its identity, given the isolation with respect to the Mediterranean and continental populations of this species. Using molecular analyses, we tested if populations from  the United Kingdom and the Iberian Peninsula were conspecific and tested the hypotheses of a recent colonization event versus a more ancient origin for the British populations. Phylogenetic analysis of the mitochondrial marker COI allowed us to conclude that the United Kingdom specimens morphologically ascribed to N. lacustris were conspecific with populations from France and the Iberian Peninsula. Based on the genetic divergence of the two reciprocally monophyletic clades from the Iberian Peninsula and Great Britain/France, respectively, the present distribution of N. lacustris can be postulated as a relatively recent dispersal or introduction into Great Britain from France.                Finally, we note the isolated position displayed by N. lacustris in the phylogenetic tree of Nemoura species based on COI sequences, as the sister to all included species of the genus. This isolated position corresponds with the specific morphology of N. lacustris genitalia and requires additional studies to ascertain clearer generic boundaries within the Nemouridae.


Assuntos
DNA Mitocondrial , Neópteros , Animais , Europa (Continente) , França , Variação Genética , Neópteros/genética , Filogenia , Reino Unido
16.
Zootaxa ; 4646(1): zootaxa.4646.1.8, 2019 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-31717031

RESUMO

Branchinecta sandiegonensis is a passively dispersed species that occurs in the vernal pool complexes of southern California, the USA, and northwestern Baja California, México. The fragmented distribution of these vernal pool complexes could limit the gene flow, generating high genetic structure and morphometric variation across the landscape. Here we estimate the genetic and phenotypic variation of B. sandiegonensis in the southern part of its range. We sampled 15 vernal pools from four geographic regions of the Baja California Peninsula. We genotyped 150 individuals using nuclear microsatellites and 31 individuals using the mitochondrial COI region. We also conducted a morphometric analysis on a sample of 232 individuals. We found moderate levels of genetic diversity and different patterns of structure depending upon the spatial scale of analysis. Demographic models suggest contrasting trends among populations. Phenotypically, we found high levels of heterogeneity in body size of fairy shrimps within and across the regions. Our findings highlight that vernal pools in Baja California are important reservoirs of genetic and phenotypic diversity for B. sandiegonensis. The interplay between gene flow and genetic drift may have influenced the patterns we detected in the southern part of the range of this species.


Assuntos
Anostraca , Crustáceos , Animais , California , DNA Mitocondrial , Variação Genética , México , Filogenia
17.
Zootaxa ; 4604(2): zootaxa.4604.2.2, 2019 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-31717189

RESUMO

Mites of the family Phytoseiidae are important predators for biological control applications. They occur naturally in ecosystems but their overall distribution is not completely known. This study presents results of surveys carried out in the south of France. It proposes the use of a combination of morphological and molecular approaches for species diagnosis. Eighteen species of the genus Typhlodromus are reported from southern France, of which nine belong to Typhlodromus (Anthoseius) and nine to Typhlodromus (Typhlodromus). Eight of these species are new to the French fauna. The mitochondrial DNA CytB gene from 85 specimens (18 species) and the 12S rRNA gene from 30 specimens (9 species) were partially sequenced and analysed. Based on molecular and morphological comparisons, the synonymy between Typhlodromus (Anthoseius) ilicis and T. (A.) creticus is discussed. High genetic distances between specimens morphologically assigned to T. (A.) rhenanoides suggests the existence of cryptic species. The reliability of integrative approaches for species identification is discussed.


Assuntos
Ácaros , Animais , DNA Mitocondrial , Ecossistema , França , Reprodutibilidade dos Testes
18.
An Acad Bras Cienc ; 91(3): e20180487, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31618408

RESUMO

Authentication of cell lines is of paramount importance to validate the results from their use in biomedical research. Although isoenzyme polymorphism is the standard method, molecular methods based on mitochondrial DNA (mtDNA) have been developed to replace it. The aim of this study was the improvement of our isoenzyme electrophoretic analysis and the validation of one molecular technique targeted at mtDNA for the authentication of our animal cell lines. The combined method of cellular lysing through osmotic shock, followed by freezing-thawing in N2 to obtain isoenzyme extracts, and with 42 × 106 cells maintained the best efficiency. The superior electrophoretic conditions were PAGE run at 200 V. All cell lines had isoenzymatic mobility corresponding to their species to lactate dehydrogenase, malate-dehydrogenase, and glucose-6-phosphate dehydrogenase isoenzymes, and could be distinguished from each other. Two molecular techniques based on mtDNA were tested, one on the cytochrome b gene and other on cytochrome c oxidase I subunit gene. Due to difficulties in distinguishing all cell lines using only one these techniques, we merged the primers of two methods in such a way that there was a sufficient differentiation of all DNA fragments. The sequencing of these PCR products was also performed to validate these data.


Assuntos
Técnicas de Cultura de Células/métodos , DNA Mitocondrial/genética , Isoenzimas/análise , Animais , Linhagem Celular , Eletroforese , Glucosefosfato Desidrogenase/análise , L-Lactato Desidrogenase/análise , Malato Desidrogenase/análise , Reação em Cadeia da Polimerase
19.
Enzymes ; 45: 257-287, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31627879

RESUMO

The mitochondrial genome encodes proteins essential for the oxidative phosphorylation and, consequently, for proper mitochondrial function. Its localization and, possibly, structural organization contribute to higher DNA damage accumulation, when compared to the nuclear genome. In addition, the mitochondrial genome mutates at rates several times higher than the nuclear, although the causal relationship between these events are not clearly established. Maintaining mitochondrial DNA stability is critical for cellular function and organismal fitness, and several pathways contribute to that, including damage tolerance and bypass, degradation of damaged genomes and DNA repair. Despite initial evidence suggesting that mitochondria lack DNA repair activities, most DNA repair pathways have been at least partially characterized in mitochondria from several model organisms, including humans. In this chapter, we review what is currently known about how the main DNA repair pathways operate in mitochondria and contribute to mitochondrial DNA stability, with focus on the enzymology of mitochondrial DNA repair.


Assuntos
Dano ao DNA , Reparo do DNA , DNA Mitocondrial/metabolismo , Mitocôndrias/genética , Humanos
20.
Enzymes ; 45: 311-341, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31627882

RESUMO

Mitochondria play a central role in bioenergetics, and fulfill a plethora of functions in cell signaling, programmed cell death, and biosynthesis of key protein cofactors. Mitochondria harbor their own genomic DNA, which encodes protein subunits of the electron transport chain and a full set of transfer and ribosomal RNAs. Mitochondrial DNA (mtDNA) is essential for cellular and organismal functions, and defects in mitochondrial genome maintenance have been implicated in common human diseases and mitochondrial disorders. mtDNA repair and degradation are known pathways to cope with mtDNA damage; however, molecular factors involved in this process have remained unclear. Such knowledge is fundamental to the understanding of mitochondrial genomic maintenance and pathology, because mtDNA degradation may contribute to the etiology of mtDNA depletion syndromes and to the activation of the innate immune response by fragmented mtDNA. This article reviews the current literature regarding the importance of mitochondrial DNA degradation in mtDNA maintenance and stress response, and the recent progress in uncovering molecular factors involved in mtDNA degradation. These factors include key components of the mtDNA replication machinery, such as DNA polymerase γ, helicase Twinkle, and exonuclease MGME1, as well as a major DNA-packaging protein, mitochondrial transcription factor A (TFAM).


Assuntos
DNA Mitocondrial/metabolismo , Genoma Mitocondrial/genética , Estresse Fisiológico , Replicação do DNA , Humanos , Doenças Mitocondriais/genética , Doenças Mitocondriais/patologia
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