Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 111
Filtrar
2.
J Clin Pediatr Dent ; 46(6): 50-53, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36624905

RESUMO

Orofacial granulomatosis (OFG) is an uncommon condition with varying clinical presentation. Gingival enlargement in children could be due to a varied etiology. The present case report is of an adolescent female with initial presentation of generalized gingival enlargement, lip swelling and perioral discoloration without any known etiopathological factors or systemic involvement. Conservative excision of the enlargement was performed and histopathological examination revealed a non caseating granulomatous lesion. Diagnosis of orofacial granulomatosis in context to sarcoidosis was arrived after excluding other granulomatous diseases. Follow up after 18 months showed no recurrence and regression of lip swelling and perioral discoloration. Gingival enlargement can be considered as one of the presenting features of sarcoidosis.


Assuntos
Hipertrofia Gengival , Granulomatose Orofacial , Sarcoidose , Adolescente , Criança , Feminino , Humanos , Hipertrofia Gengival/etiologia , Granulomatose Orofacial/diagnóstico , Granulomatose Orofacial/etiologia , Granulomatose Orofacial/patologia , Sarcoidose/complicações
3.
J Clin Pediatr Dent ; 43(1): 46-50, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30289370

RESUMO

Autoimmune neutropenia is a self-limiting condition characterized by the presence of granulocyte-specific autoantibodies. This case report describes a 2-year-old female who presented to the Department of Pediatric Dentistry with a history of oral ulceration, complicated by high temperature, gingival hypertrophy and gingival hemorrhage. These symptoms had precipitated an admission to a district general hospital and diagnosis of viral tonsillitis. The severity of the presentation to the Pediatric Dental Department prompted a review of recent discharge blood investigations, which revealed a neutrophil count of 0.07×109/L(1.0-8.5 ×109/L) indicating severe neutropenia. Urgent referral to Pediatric Hematology resulted in same-day admission and a diagnosis of autoimmune neutropenia was established. The patient was managed with chlorhexidine mouthwash, prophylactic antimicrobial and antifungal medication and granulocyte colony stimulating factor (G-CSF). Neutropenia may present with features exclusive to the oral cavity. Recognition of atypical presentations such as oral ulceration with associated systemic illness may assist in early diagnosis.


Assuntos
Hemorragia Gengival , Hipertrofia Gengival , Neutropenia , Úlceras Orais/etiologia , Criança , Pré-Escolar , Feminino , Hemorragia Gengival/etiologia , Hipertrofia Gengival/etiologia , Fator Estimulador de Colônias de Granulócitos , Humanos , Neutropenia/complicações , Neutropenia/diagnóstico
4.
J Ayub Med Coll Abbottabad ; 30(3): 345-350, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30465363

RESUMO

BACKGROUND: Renal transplant is the renal replacement therapy of choice for all patients of chronic kidney disease. The aim of this study was to analyse the trends of medical complications in renal transplant recipients at our centre. METHODS: it is a prospective cross sectional descriptive study. All the patients undergoing renal transplant at Armed Forces Institute of Urology from September 2013 to September 2015 were included in the study. The patients were followed prospectively till March 2016 and a complete data about their complications and lab investigations was maintained.. RESULTS: This study included a total of 63 patients with a mean duration of follow-up of 14.05 months (SD±4.45). Infective complications as a group are the commonest complication occurring in over 50% of cases followed by haematological complications (17.5%), new onset diabetes after transplant (15.9%) and transplant dysfunction (14.3%) Cardiovascular complications were seen in only 4.8% cases but with high mortality. Gingival hypertrophy was seen in 4.8% cases. CONCLUSIONS: Medical complications are common after renal transplant especially in the early post-operative period. The only way forward is early recognition and aggressive treatment, as delays can cost losses in the form of kidney function, life and higher health care cost.


Assuntos
Doenças Hematológicas/etiologia , Infecções/etiologia , Transplante de Rim/efeitos adversos , Complicações Pós-Operatórias/etiologia , Adulto , Aloenxertos/fisiopatologia , Doenças Cardiovasculares/etiologia , Estudos Transversais , Diabetes Mellitus/etiologia , Feminino , Hipertrofia Gengival/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Adulto Jovem
8.
Ear Nose Throat J ; 95(1): E14-6, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26829688

RESUMO

Urbach-Wiethe disease (lipoid proteinosis) is an autosomal recessive disorder that is characterized by a general thickening of the skin and mucous membranes. We report the case of a 22-year-old woman with lipoid proteinosis who presented with hoarseness, poor dentition, and skin lesions, and we discuss the management of this rare disease.


Assuntos
Proteinose Lipoide de Urbach e Wiethe/diagnóstico , Feminino , Hipertrofia Gengival/etiologia , Rouquidão/etiologia , Humanos , Laringoscopia , Proteinose Lipoide de Urbach e Wiethe/complicações , Proteinose Lipoide de Urbach e Wiethe/patologia , Úlceras Orais/etiologia , Prega Vocal/patologia , Adulto Jovem
9.
Arch Pediatr ; 23(1): 71-4, 2016 Jan.
Artigo em Francês | MEDLINE | ID: mdl-26552632

RESUMO

Mucolipidosis type II (ML II, OMIM 252,500) is an autosomal recessive disorder clinically characterized by facial dysmorphia similar to Hurler syndrome and pronounced gingival hypertrophy. The disorder is caused by a defect in targeting acid hydrolases on the surface of lysosomes, which impede their entry and lead to accumulation of undigested substrates in lysosomes. The onset of the symptoms is usually in infancy, beginning in the 6th month of life. Early onset, at birth or even in utero, is a sign of severity and involves the specific dysmorphia as well as skeletal dysplasia related to hyperparathyroidism. We report on a severe neonatal form of this disorder revealed by respiratory distress with severe chest deformity. The dysmorphic syndrome, combining coarse features, pronounced gingival hypertrophy, with diffuse bone demineralization and secondary hyperparathyroidism associating significant elevation of parathyroid hormone and alkaline phosphatase with normal levels of vitamin D and calcium were characteristics of mucolipidosis type II. Recognizing this specific association of anomalies helps eliminate the differential diagnosis and establish appropriate diagnosis and care.


Assuntos
Mucolipidoses/diagnóstico , Fosfatase Alcalina/sangue , Desmineralização Patológica Óssea/etiologia , Hipertrofia Gengival/etiologia , Humanos , Hiperparatireoidismo Secundário/etiologia , Recém-Nascido , Masculino , Hormônio Paratireóideo/sangue , Índice de Gravidade de Doença
11.
Niger J Clin Pract ; 18(4): 573-6, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25966736

RESUMO

Acute myeloid leukemias (AMLs) are aggressive hematopoietic neoplasms that, if untreated, can lead to death within days. Owing to its high morbidity rate, early diagnosis and appropriate medical therapy is essential. Oral lesions may be the presenting feature of acute leukemias and are, therefore, important diagnostic indicators of the disease. Erythematous or cyanotic gingival hyperplasia with or without necrosis is reported to be the most consistent symptom leading to a diagnosis of acute leukemia that directs the patient to seek early dental consultation. This report refers to a patient with AML that was provisionally diagnosed in the dental hospital due to severe gingival enlargements.


Assuntos
Gengiva/patologia , Hipertrofia Gengival/diagnóstico , Leucemia Mieloide Aguda/diagnóstico , Adulto , Diagnóstico Diferencial , Hipertrofia Gengival/etiologia , Humanos , Leucemia Mieloide Aguda/complicações , Masculino
12.
J Periodontol ; 86(1): 62-71, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25269522

RESUMO

BACKGROUND: Human multipotent mesenchymal stromal cells (hMSCs) produce tumor necrosis factor (TNF)-α-stimulated protein 6 (TSG-6). TSG-6 modulates proinflammatory cytokine cascades and enhances tissue repair. This study tests the effects of recombinant human TSG-6 (rhTSG-6) on gingival wound healing within the first 2 days post-surgery. METHODS: After gingival resection in 120 Sprague-Dawley rats, 2 µg rhTSG-6 in 5-µL phosphate-buffered saline (PBS) or the same volume of only PBS solution was injected into gingival tissue approximating the surgical wound. Control animals did not receive injections. Tissue biopsies and blood were collected at 1 to 2, 6 to 8, 24, and 48 hours post-surgery (n = 10 per group). Specimens were analyzed via histologic analysis and enzyme-linked immunosorbent assay (ELISA) for quantification and comparison of inflammatory markers interleukin (IL)-1ß, IL-6, TNF-α, and myeloperoxidase (MPO). Wound photographs were taken for a double-masked clinical assessment at each time period. Weights were recorded for all animals pre- and post-surgery. RESULTS: Animals injected with rhTSG-6 had significantly less severe clinical inflammation at 6 to 8 (P = 0.01228), 24 (P = 0.01675), and 48 (P = 0.0186) hours. Sham and control animals had more weight loss at 24 and 48 hours. Sham and control animals had more pronounced cellular infiltrate. rhTSG-6-treated animals had significantly less MPO (P = 0.027) at 24 hours and IL-1ß (P = 0.027) at 24 and 48 hours. IL-6 showed a marginal significant difference at 6 to 8 hours, but there was no significant difference for TNF-α. CONCLUSION: rhTSG-6 reduced postoperative gingival inflammation by reducing levels of proinflammatory cytokines and cellular infiltrate and may offer significant promise as an anti-inflammatory agent for gingival surgery.


Assuntos
Moléculas de Adesão Celular/uso terapêutico , Gengiva/efeitos dos fármacos , Gengivectomia/métodos , Fator de Necrose Tumoral alfa/uso terapêutico , Animais , Anti-Inflamatórios/uso terapêutico , Peso Corporal , Moléculas de Adesão Celular/análise , Eritema/etiologia , Eritema/metabolismo , Gengiva/química , Doenças da Gengiva/etiologia , Doenças da Gengiva/metabolismo , Hemorragia Gengival/etiologia , Hemorragia Gengival/metabolismo , Hipertrofia Gengival/etiologia , Hipertrofia Gengival/metabolismo , Gengivite/etiologia , Gengivite/metabolismo , Humanos , Mediadores da Inflamação/análise , Interleucina-1beta/análise , Interleucina-1beta/efeitos dos fármacos , Interleucina-6/análise , Masculino , Peroxidase/análise , Peroxidase/efeitos dos fármacos , Ratos , Ratos Sprague-Dawley , Proteínas Recombinantes , Fatores de Tempo , Fator de Necrose Tumoral alfa/análise , Cicatrização/efeitos dos fármacos
14.
Pathologica ; 106(2): 70-2, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25291871

RESUMO

Juvenile hyaline fibromatosis is a rare, hereditary disease with distinct clinical and histopathological features. Clinically, it presents with gingival hypertrophy, pappulonodular skin lesions and joint contractures. Bone involvement is usually an uncommon finding. We report a case of a 2-year-old patient, daughter of consanguineous parents, who presented since the age of 2 months with impairment of mental development, multiple joint contractures, motion limitation and nodules on the scalp. The calvarian lesions were surgically removed, and histopathological examination concluded to juvenile hyaline fibromatosis.


Assuntos
Hialina/metabolismo , Síndrome da Fibromatose Hialina/diagnóstico , Biomarcadores/metabolismo , Biópsia , Encéfalo/metabolismo , Encéfalo/patologia , Pré-Escolar , Contratura/diagnóstico , Contratura/etiologia , Contratura/metabolismo , Feminino , Hipertrofia Gengival/diagnóstico , Hipertrofia Gengival/etiologia , Hipertrofia Gengival/metabolismo , Humanos , Síndrome da Fibromatose Hialina/complicações , Síndrome da Fibromatose Hialina/metabolismo , Síndrome da Fibromatose Hialina/patologia , Síndrome da Fibromatose Hialina/cirurgia , Imageamento por Ressonância Magnética , Valor Preditivo dos Testes , Pele/metabolismo , Pele/patologia
15.
Fogorv Sz ; 106(2): 61-70, 2013 Jun.
Artigo em Húngaro | MEDLINE | ID: mdl-24344562

RESUMO

INTRODUCTION: Gingival enlargement is a common form of periodontal tissue reaction to several irritating factors. The most common form is the drug related gingival hyperplasia--nevertheless the heredity gingival fibromatosis and hematological cases can also occur and might impose a challenge to periodontists. After a short literature summary three Case reports are presented. The first case is a drug related gingival overgrowth in a young kidney transplant women who took Cyclosporin-A. The excessive mass of fibrotic tissue was removed by a series of internal beveled incision and the oral and buccal gingival flaps were united with sutures. The healing was uneventful and during the follow up patient's compliance and oral hygiene was superb. The second case is a very severe antihypertensive drug related gingival overgrowth in a 62 years old man interfering with the closure of his lip and corrected with a combination of conventional gingivectomy and internal reverse beveled incision both and Ca-channel blockers. The third case is a 42 years old woman with chronic idiopathic hemolytic anemia who presented a sudden onset acute excessive generalized gingival enlargement accompanied with severe pain and fever. At admission she was suspect for leukemia. After obtaining biopsy samples and having negative histology the soft tissue mass was removed under general anesthesia with conventional gingivectomy technique, but after a couple of days the severe pain and gingival swelling recurred. With administering systemic corticosteroid therapy (32 mg Medrol), the gingiva healed in five days and the one year follow-up showed a stable hematological and periodontal status. Today the more conservative internal beveled incision is preferred over the conventional gingivectomy in the most cases because it provides a more predictable healing and better esthetics. The recurrence of the drug related gingival hyperplasia can be anticipated by meticulous postoperative individual oral hygiene and regular supportive therapy. CONCLUSION: The combined conservative and surgical therapy leads to predictable postoperative result even in very severe systematically motivated gingival enlargements, nevertheless the successful patients management needs good cooperation with medical doctors and with the patients themselves.


Assuntos
Hiperplasia Gengival/etiologia , Hiperplasia Gengival/cirurgia , Hipertrofia Gengival/etiologia , Hipertrofia Gengival/cirurgia , Gengivectomia , Adulto , Idoso , Anemia Hemolítica/complicações , Anti-Hipertensivos/administração & dosagem , Anti-Hipertensivos/efeitos adversos , Bloqueadores dos Canais de Cálcio/administração & dosagem , Bloqueadores dos Canais de Cálcio/efeitos adversos , Ciclosporina/administração & dosagem , Ciclosporina/efeitos adversos , Feminino , Febre/etiologia , Hiperplasia Gengival/induzido quimicamente , Hiperplasia Gengival/complicações , Hipertrofia Gengival/induzido quimicamente , Hipertrofia Gengival/complicações , Gengivectomia/métodos , Granuloma/complicações , Humanos , Imunossupressores/administração & dosagem , Imunossupressores/efeitos adversos , Transplante de Rim , Masculino , Pessoa de Meia-Idade , Higiene Bucal , Dor/etiologia , Supuração , Resultado do Tratamento
16.
Artigo em Francês | MEDLINE | ID: mdl-23838247

RESUMO

INTRODUCTION: Cowden syndrome is rare; oral symptoms are not always diagnosed. This case of Cowden syndrome was revealed by gingival hypertrophy. OBSERVATION: A 21-year-old female patient consulted for gingival hypertrophy and multiple papules in the mouth. She had a history of thyroid lobectomy due to a goiter. The gingival papillomatosis and the goiter suggested a Cowden syndrome. The diagnosis was confirmed clinically by facial skin papules. DISCUSSION: Cutaneous and oral lesions are usually the first symptoms of the syndrome. Diffuse gingival papillomatosis may suggest a Cowden syndrome and should lead to screen for associated symptoms. A high-risk diagnosis of breast and thyroid cancer is associated to Cowden syndrome and the patient should have a yearly follow-up.


Assuntos
Hipertrofia Gengival/diagnóstico , Síndrome do Hamartoma Múltiplo/diagnóstico , Ceco , Feminino , Hipertrofia Gengival/etiologia , Síndrome do Hamartoma Múltiplo/complicações , Humanos , Pólipos Intestinais/diagnóstico , Pólipos Intestinais/etiologia , Adulto Jovem
18.
Minerva Stomatol ; 61(5): 233-8, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22576448

RESUMO

Oral cavity reflects the health status of an individual. Many systemic diseases have signs and symptoms that manifest in the oral cavity, which in most of the cases precede the systemic manifestations. These array of diseases also include acute leukemias which present as gingival hyperplasia as the most consistent symptom seeking dental consultation that can be easily confused with many other benign conditions that present as gingival enlargements. One such rare case of adult acute lymphoblastic leukemia is presented in this article.


Assuntos
Hipertrofia Gengival/etiologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/diagnóstico , Biomarcadores Tumorais/análise , Biópsia , Medula Óssea/patologia , Diagnóstico Diferencial , Evolução Fatal , Feminino , Hipertrofia Gengival/patologia , Humanos , Leiomioma/diagnóstico , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/diagnóstico , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Leucemia-Linfoma Linfoblástico de Células Precursoras/patologia , Recusa do Paciente ao Tratamento , Neoplasias Uterinas/diagnóstico , Redução de Peso
19.
Quintessence Int ; 43(4): 337-41, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22532949

RESUMO

OBJECTIVE: Biliary atresia is a congenital disease treated by liver transplantation. Adults may have oral consequences of the medical therapy. Green teeth are oral manifestations of the induced hyperbilirubinemia. Gingival enlargement is associated with the immunosuppressive drug. This case report describes the successful treatment of an 18-year-old patient displaying severe green teeth and gingival enlargement. METHOD AND MATERIALS: The gingival enlargement was treated by reducing the pathogenic oral microflora through scaling and root planing of the teeth, gingival excision surgeries, and conversion from cyclosporin to tacrolimus. RESULTS: Gingival enlargement and inflammation had completely disappeared after nonsurgical treatment for the maxilla and after surgical treatment for the mandible. The green coloration of the teeth was masked using composite restorations. CONCLUSION: This case report indicates that a patient's quality of life can be improved by a team approach combining pharmacologic and dental therapies.


Assuntos
Atresia Biliar/complicações , Assistência Odontológica para Doentes Crônicos , Facetas Dentárias , Hipertrofia Gengival/etiologia , Descoloração de Dente/etiologia , Adolescente , Atresia Biliar/cirurgia , Hipertrofia Gengival/terapia , Humanos , Hiperbilirrubinemia/complicações , Hiperbilirrubinemia/etiologia , Hiperbilirrubinemia/cirurgia , Imunossupressores/efeitos adversos , Transplante de Fígado , Masculino , Qualidade de Vida , Descoloração de Dente/reabilitação
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...