Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 6.944
Filtrar
1.
Nat Commun ; 11(1): 4722, 2020 09 18.
Artigo em Inglês | MEDLINE | ID: mdl-32948764

RESUMO

Precisely controlled deuterium labeling at specific sites of N-alkyl drugs is crucial in drug-development as over 50% of the top-selling drugs contain N-alkyl groups, in which it is very challenging to selectively replace protons with deuterium atoms. With the goal of achieving controllable isotope-labeling in N-alkylated amines, we herein rationally design photocatalytic water-splitting to furnish [H] or [D] and isotope alkanol-oxidation by photoexcited electron-hole pairs on a polymeric semiconductor. The controlled installation of N-CH3, -CDH2, -CD2H, -CD3, and -13CH3 groups into pharmaceutical amines thus has been demonstrated by tuning isotopic water and methanol. More than 50 examples with a wide range of functionalities are presented, demonstrating the universal applicability and mildness of this strategy. Gram-scale production has been realized, paving the way for the practical photosynthesis of pharmaceuticals.


Assuntos
Aminas/química , Aminas/metabolismo , Luz , Semicondutores , Alquilação , Aminas/farmacologia , Catálise , Deutério , Oxirredução , Preparações Farmacêuticas , Prótons , Água , Difração de Raios X
2.
Nat Commun ; 11(1): 3823, 2020 07 30.
Artigo em Inglês | MEDLINE | ID: mdl-32732934

RESUMO

An accurate extraction of physiological and physical signals from human skin is crucial for health monitoring, disease prevention, and treatment. Recent advances in wearable bioelectronics directly embedded to the epidermal surface are a promising solution for future epidermal sensing. However, the existing wearable bioelectronics are susceptible to motion artifacts as they lack proper adhesion and conformal interfacing with the skin during motion. Here, we present ultra-conformal, customizable, and deformable drawn-on-skin electronics, which is robust to motion due to strong adhesion and ultra-conformality of the electronic inks drawn directly on skin. Electronic inks, including conductors, semiconductors, and dielectrics, are drawn on-demand in a freeform manner to develop devices, such as transistors, strain sensors, temperature sensors, heaters, skin hydration sensors, and electrophysiological sensors. Electrophysiological signal monitoring during motion shows drawn-on-skin electronics' immunity to motion artifacts. Additionally, electrical stimulation based on drawn-on-skin electronics demonstrates accelerated healing of skin wounds.


Assuntos
Monitorização Fisiológica/instrumentação , Sistemas Automatizados de Assistência Junto ao Leito , Pele/fisiopatologia , Dispositivos Eletrônicos Vestíveis , Artefatos , Estimulação Elétrica , Epiderme/fisiologia , Humanos , Movimento (Física) , Semicondutores , Auxiliares Sensoriais , Pele/lesões , Cicatrização
3.
Science ; 369(6503): 509, 2020 07 31.
Artigo em Inglês | MEDLINE | ID: mdl-32732412
4.
J Vis Exp ; (160)2020 06 25.
Artigo em Inglês | MEDLINE | ID: mdl-32658181

RESUMO

This protocol demonstrates a method for graphene-assisted quick growth and coalescence of AlN on nano-pattened sapphire substrate (NPSS). Graphene layers are directly grown on NPSS using catalyst-free atmospheric-pressure chemical vapor deposition (APCVD). By applying nitrogen reactive ion etching (RIE) plasma treatment, defects are introduced into the graphene film to enhance chemical reactivity. During metal-organic chemical vapor deposition (MOCVD) growth of AlN, this N-plasma treated graphene buffer enables AlN quick growth, and coalescence on NPSS is confirmed by cross-sectional scanning electron microscopy (SEM). The high quality of AlN on graphene-NPSS is then evaluated by X-ray rocking curves (XRCs) with narrow (0002) and (10-12) full width at half-maximum (FWHM) as 267.2 arcsec and 503.4 arcsec, respectively. Compared to bare NPSS, AlN growth on graphene-NPSS shows significant reduction of residual stress from 0.87 GPa to 0.25 Gpa, based on Raman measurements. Followed by AlGaN multiple quantum wells (MQWS) growth on graphene-NPSS, AlGaN-based deep ultraviolet light-emitting-diodes (DUV LEDs) are fabricated. The fabricated DUV-LEDs also demonstrate obvious, enhanced luminescence performance. This work provides a new solution for the growth of high quality AlN and fabrication of high performance DUV-LEDs using a shorter process and less costs.


Assuntos
Óxido de Alumínio/química , Grafite/química , Nanoestruturas/química , Semicondutores , Raios Ultravioleta , Compostos de Alumínio/química , Catálise , Gálio/química , Gases/química , Luminescência , Volatilização
5.
Science ; 369(6500): 138-139, 2020 07 10.
Artigo em Inglês | MEDLINE | ID: mdl-32646984
6.
Stud Health Technol Inform ; 271: 9-16, 2020 Jun 23.
Artigo em Inglês | MEDLINE | ID: mdl-32578535

RESUMO

Optoelectronic neurostimulation is a promising, minimally invasive treatment modality for neuronal damage, in particular for patients with traumatic brain injury. In this work, a newly developed optoelectronic device, a so-called photocap, based on light-activated organic semiconductor structures with high spatial and temporal resolution is investigated. To prove and verify the feasibility of this new technology, a mathematical model was developed, simulating the electrical response of excitable cells to photocap stimulation. In the first step, a comprehensive technical review of the device concept was performed, building the basis for setting up the simulation model. The simulations demonstrate that photocaps may serve as a stimulation device, triggering action potentials in neural or cardiac cells. Our first results show that the model serves as a perfect tool for evaluating and further developing this new technology, showing high potential for introducing new and innovative therapy methods in the field of optoelectronic cell stimulation.


Assuntos
Neurônios , Semicondutores , Potenciais de Ação , Humanos , Modelos Teóricos
7.
Sci Total Environ ; 740: 140080, 2020 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-32562993

RESUMO

Intimate coupling of microbial extracellular electron transfer (EET) and photoelectrochemical processes is an emerging research area with great potential to circumvent many disadvantages associated with traditional techniques that depend on independent microbial or photocatalysis treatment. Microbial EET processes involve microorganism oxidation of extracellular electron donors for respiration and synchronous reduction of extracellular electron acceptors to form an integrated respiratory chain. Coupled microbial EET-photoelectrochemical technologies greatly improve energy conversion efficiency providing both economic and environmental benefits. Among substitutes for semiconductor photocatalysts, cadmium sulfide nanoparticles (CdS NPs) possess several attractive properties. Specifically, CdS NPs have suitable electrical conductivity, large specific surface area, visible light-driven photocatalysis capability and robust biocompatibility, enabling them to promote hybrid microbial-photoelectrochemical processes. This review highlights recent advances in intimately coupled CdS NPs-microbial extracellular electron transfer systems and examines the mechanistic pathways involved in photoelectrochemical transformations. Finally, the prospects for emerging applications utilizing hybrid CdS NPs-based microbial-photoelectrochemical technologies are assessed. As such, this review provides a rigorous fundamental analysis of electron transport dynamics for hybrid CdS NPs-microbial photoelectrochemical processes and explores the applicability of engineered CdS NPs-biohybrids for future applications, such as in environmental remediation and clean-energy production.


Assuntos
Compostos de Cádmio , Nanopartículas , Semicondutores , Sulfetos
8.
Environ Pollut ; 265(Pt A): 114877, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32531651

RESUMO

The use of polymers such as plastic has become an important part of daily life, and in aqueous environments, these polymers are considered as pollutants. When macropolymers are reduced to the nanoscale, their small particle size and large specific surface area facilitate their uptake by plants, which has a significant impact on aquatic plants. Therefore, it is essential to study the pollution of nanoscale polymers in the aquatic environment. In this work, we prepared nanoscale polymer dots (Pdots) and explored their toxicity, uptake and transport mechanisms in penny grass. From toxicological studies, in the absence of other nutrients, the cell structure, physiological parameters (total soluble protein and chlorophyll) and biochemical parameters (malondialdehyde) do not show significant changes over at least five days. Through in vivo fluorescence and photoacoustic (PA) imaging, the transport location can be visually detected accurately, and the transport rate can be analyzed without destroying the plants. Moreover, through ex vivo fluorescence imaging, we found that different types of Pdots have various uptake and transport mechanisms in stems and blades. It may be due to the differences in ligands, particle sizes, and oil-water partition coefficients of Pdots. By understanding how Pdots interact with plants, a corresponding method can be developed to prevent them from entering plants, thus avoiding the toxicity from accumulation. Therefore, the results of this study also provide the basis for subsequent prevention work.


Assuntos
Centella , Polímeros , Fluorescência , Poaceae , Semicondutores
9.
Chemosphere ; 257: 127123, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32505037

RESUMO

It is a central issue to improve the separation efficiency of photogenerated charge carriers and the utilization of visible light in the field of photocatalysis. Herein, taking MIL-125(Ti) as a host material, the Pt/MIL-125(Ti) was first prepared by solvothermal method to build the interface of Schottky junction. Ag was then introduced onto the surface of Pt/MIL-125(Ti) to form the interface with the surface plasmon resonance effect. These double interfaces in the composite play a synergistic role on the photodagradation. The morphology, crystallinity and photochemical properties of the material were tested. By comparison, Pt/MIL-125(Ti)/Ag (4 wt% Ag) exhibited the best performance in the photodegradation of ketoprofen (KP, 10 mg/L) and the degradation process conformed to the pseudo-first-order kinetics. The photodegradation rate is 0.0253 min-1, which was higher than MIL-125(Ti) (0.0009 min-1). The TOC removal efficiency of KP reached approximately 51.5%. The electron paramagnetic resonance (EPR) and free radical capture tests verified that h+ and ·OH played the prominent roles during the reaction system. The degradation process, possible pathways and reaction mechanism were proposed. The design of the double interfaces between semiconductor and noble metals is a novel strategy to enhance the photocatalytic performance.


Assuntos
Cetoprofeno/química , Modelos Químicos , Catálise , Luz , Dietilamida do Ácido Lisérgico/análogos & derivados , Fotólise , Semicondutores , Prata/química , Titânio/química
10.
PLoS One ; 15(5): e0232184, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32369508

RESUMO

The ternary chalcogenide Cu3VSe4 (CVSe) with sulvanite structure has been theoretically predicted to be a promising candidate for photovoltaic applications due to its suitable bandgap for solar absorption and the relatively earth-abundant elements in its composition. To realize the absorber layer via an inexpensive route, printed thin-films could be fabricated from dispersions of nano-sized Cu3VSe4 precursors. Herein, cubic Cu3VSe4 nanocrystals were successfully synthesized via a hot-injection method. Similar with reported Cu3VS4 nanocrystals, Cu3VSe4 nanocrystals with cubic structure exhibit three absorption bands in the UV-Visible range indicative of a potential intermediate bandgap existence. A thin film fabricated by depositing the nanoparticles Cu3VSe4 on FTO coated glass substrate, exhibited a p-type behavior and a photocurrent of ~ 4 µA/cm2 when measured in an electrochemical cell setting. This first demonstration of photocurrent exhibited by a CVSe nanocrystals thin film signifies a promising potential in photovoltaic applications.


Assuntos
Nanopartículas/química , Compostos de Selênio/química , Compostos de Selênio/síntese química , Técnicas Eletroquímicas , Nanopartículas/ultraestrutura , Tamanho da Partícula , Processos Fotoquímicos , Semicondutores
11.
Nat Commun ; 11(1): 2405, 2020 05 15.
Artigo em Inglês | MEDLINE | ID: mdl-32415064

RESUMO

Fiber-based electronics enabling lightweight and mechanically flexible/stretchable functions are desirable for numerous e-textile/e-skin optoelectronic applications. These wearable devices require low-cost manufacturing, high reliability, multifunctionality and long-term stability. Here, we report the preparation of representative classes of 3D-inorganic nanofiber network (FN) films by a blow-spinning technique, including semiconducting indium-gallium-zinc oxide (IGZO) and copper oxide, as well as conducting indium-tin oxide and copper metal. Specifically, thin-film transistors based on IGZO FN exhibit negligible performance degradation after one thousand bending cycles and exceptional room-temperature gas sensing performance. Owing to their great stretchability, these metal oxide FNs can be laminated/embedded on/into elastomers, yielding multifunctional single-sensing resistors as well as fully monolithically integrated e-skin devices. These can detect and differentiate multiple stimuli including analytes, light, strain, pressure, temperature, humidity, body movement, and respiratory functions. All of these FN-based devices exhibit excellent sensitivity, response time, and detection limits, making them promising candidates for versatile wearable electronics.


Assuntos
Nanopartículas Metálicas/química , Nanofibras/química , Dispositivos Eletrônicos Vestíveis , Consumo de Bebidas Alcoólicas , Técnicas Biossensoriais , Testes Respiratórios , Cobre/química , Elastômeros , Etanol/análise , Análise de Elementos Finitos , Gálio/química , Humanos , Índio/química , Teste de Materiais , Movimento (Física) , Poliestirenos/química , Semicondutores , Espectrofotometria Ultravioleta , Temperatura , Têxteis , Óxido de Zinco/química
12.
Nat Commun ; 11(1): 1857, 2020 04 20.
Artigo em Inglês | MEDLINE | ID: mdl-32312987

RESUMO

Despite its growing promise in cancer treatment, ferrotherapy has low therapeutic efficacy due to compromised Fenton catalytic efficiency in tumor milieu. We herein report a hybrid semiconducting nanozyme (HSN) with high photothermal conversion efficiency for photoacoustic (PA) imaging-guided second near-infrared photothermal ferrotherapy. HSN comprises an amphiphilic semiconducting polymer as photothermal converter, PA emitter and iron-chelating Fenton catalyst. Upon photoirradiation, HSN generates heat not only to induce cytotoxicity but also to enhance Fenton reaction. The increased ·OH generation promotes both ferroptosis and apoptosis, oxidizes HSN (42 nm) and transforms it into tiny segments (1.7 nm) with elevated intratumoral permeability. The non-invasive seamless synergism leads to amplified therapeutic effects including a deep ablation depth (9 mm), reduced expression of metastasis-related proteins and inhibition of metastasis from primary tumor to distant organs. Thereby, our study provides a generalized nanozyme strategy to compensate both ferrotherapy and phototherapeutics for complete tumor regression.


Assuntos
Ferro/uso terapêutico , Neoplasias/patologia , Neoplasias/terapia , Fototerapia/métodos , Polímeros/química , Semicondutores , Animais , Apoptose , Catálise , Linhagem Celular Tumoral , Quelantes , Ferroptose , Células HeLa , Humanos , Peróxido de Hidrogênio , Neoplasias Hepáticas/patologia , Neoplasias Pulmonares/patologia , Camundongos , Microscopia Confocal , Células NIH 3T3 , Nanomedicina/métodos , Nanopartículas/química , Metástase Neoplásica , Neoplasias/metabolismo , Oxigênio/química , Técnicas Fotoacústicas , Ratos , Espécies Reativas de Oxigênio/metabolismo
13.
Int J Nanomedicine ; 15: 1863-1870, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32231432

RESUMO

Background: Electronic devices which mimic the functionality of biological synapses are a large step to replicate the human brain for neuromorphic computing and for numerous medical research investigations. One of the representative synaptic behaviors is paired-pulse facilitation (PPF). It has been widely investigated because it is regarded to be related to biological memory. However, plasticity behavior is only part of the human brain memory behavior. Methods: Here, we present a phenomenon which is opposite to PPF, i.e., paired-pulse inhibition (PPI), in nano oxide devices for the first time. The research here suggests that rather than being enhanced, the phenomena of memory loss would also be possessed by such electronic devices. The device physics mechanism behind memory loss behavior was investigated. This mechanism is sustained by historical memory and degradation manufactured by device trauma to regulate characteristically stimulated origins of artificial transmission behaviors. Results: Under the trauma of a memory device, both the signal amplitude and signal time stimulated by a pulse are lower than the first signal stimulated by a previous pulse in the PPF, representing a new scenario in the struggle for memory. In this way, more typical human brain behaviors could be simulated, including the effect of age on latency and error generation, cerebellar infarct, trauma and memory loss pharmacological actions (such as those caused by hyoscines and nitrazepam). Conclusion: Thus, this study developed a new approach for implementing the manner in which the brain works in semiconductor devices for improving medical research.


Assuntos
Semicondutores , Sinapses/fisiologia , Biomimética , Encéfalo/fisiologia , Desenho de Equipamento , Nanoestruturas , Plasticidade Neuronal , Óxidos/metabolismo
14.
Food Chem ; 324: 126893, 2020 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-32344336

RESUMO

An Au patch electrode Ag-SnO2/SiO2/Si MIS capacitive sensor equipped with a microcontroller was designed and developed to sense low concentration (ppb to ppm regime) of volatiles (NH3, TMA, ethanol, and H2S) generated from chicken meat spoilage at room temperature. The quality threshold or the acceptance limit for consumption of chicken meat samples stored at 4 °C, 15 °C and 25 °C using our proposed technique was found to be 105 h, 48 h, and 17 h respectively, highly correlated with TVB-N, TVC, pH and sensory evaluation analysis. When these well established standard methods (TVB-N, TVC and pH analysis) take many hours to complete the analysis involving many complicated steps, our fabricated sensor takes 55 sec to deliver sensing response reflecting the meat spoilage status. The sensor calibrated with our compact technique promises portable and inexpensive onsite rapid and accurate quality assessment of meat spoilage at room temperature.


Assuntos
Gases/análise , Ouro/química , Carne/análise , Semicondutores , Amônia/análise , Animais , Galinhas , Eletrodos , Qualidade dos Alimentos , Sulfeto de Hidrogênio/análise , Concentração de Íons de Hidrogênio , Silício/química , Dióxido de Silício/química , Prata/química , Temperatura , Compostos de Estanho/química
15.
Nat Commun ; 11(1): 1135, 2020 02 28.
Artigo em Inglês | MEDLINE | ID: mdl-32111825

RESUMO

Cancer stem cells (CSC) can be identified by modifications in their genomic DNA. Here, we report a concept of precisely shrinking an organic semiconductor surface-enhanced Raman scattering (SERS) probe to quantum size, for investigating the epigenetic profile of CSC. The probe is used for tag-free genomic DNA detection, an approach towards the advancement of single-molecule DNA detection. The sensor detected structural, molecular and gene expression aberrations of genomic DNA in femtomolar concentration simultaneously in a single test. In addition to pointing out the divergences in genomic DNA of cancerous and non-cancerous cells, the quantum scale organic semiconductor was able to trace the expression of two genes which are frequently used as CSC markers. The quantum scale organic semiconductor holds the potential to be a new tool for label-free, ultra-sensitive multiplexed genomic analysis.


Assuntos
Materiais Biocompatíveis/química , DNA/química , Genoma Humano , Semicondutores , Animais , Composição de Bases , Biomarcadores Tumorais/genética , Biomarcadores Tumorais/metabolismo , Técnicas Biossensoriais/instrumentação , Linhagem Celular , Metilação de DNA , Epigênese Genética , Expressão Gênica , Humanos , Camundongos , Células-Tronco Neoplásicas/metabolismo , Células-Tronco Neoplásicas/patologia , Pontos Quânticos/química , Reprodutibilidade dos Testes , Análise Espectral Raman
16.
PLoS One ; 15(3): e0229382, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32142551

RESUMO

Conversion of vacuum fluctuations into real particles was first predicted by L. Parker considering an expanding universe, followed in S. Hawking's work on black hole radiation. Since their experimental observation is challenging, analogue systems have gained attention in the verification of this concept. Here we propose an experimental set-up consisting of two adjacent piezoelectric semiconducting layers, one of them carrying dynamic quantum dots (DQDs), and the other being p-doped with an attached gate on top, which introduces a space-dependent layer conductivity. The propagation of surface acoustic waves (SAWs) on the latter layer is governed by a wave equation with an effective metric. In the frame of the DQDs, this space- and time-dependent metric possesses a sonic horizon for SAWs and resembles that of a two dimensional non-rotating and uncharged black hole to some extent. The non-thermal steady state of the DQD spin indicates particle creation in form of piezophonons.


Assuntos
Sistemas Microeletromecânicos/métodos , Modelos Teóricos , Pontos Quânticos , Semicondutores , Simulação por Computador , Elétrons , Tamanho da Partícula , Física , Espalhamento de Radiação
17.
PLoS One ; 15(3): e0227368, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32130215

RESUMO

The idea that households produce and consume their own energy, that is, energy self-sufficiency at a very local level, captures the popular imagination and commands political support across parts of Europe. This paper investigates the technical and economic feasibility of household energy self-sufficiency in Switzerland, which can be seen as representative for other regions with a temperate climate, by 2050. We compare sixteen cases that vary across four dimensions: household type, building type, electricity demand reduction, and passenger vehicle use patterns. We assume that photovoltaic (PV) electricity supplies all energy, which implies a complete shift away from fossil fuel based heating and internal combustion engine vehicles. Two energy storage technologies are considered: short-term storage in lithium-ion batteries and long-term storage with hydrogen, requiring an electrolyzer, storage tank, and a fuel cell for electricity conversion. We examine technological feasibility and total system costs for self-sufficient households compared to base cases that rely on fossil fuels and the existing power grid. PV efficiency and available rooftop/facade area are most critical with respect to the overall energy balance. Single-family dwellings with profound electricity demand reduction and urban mobility patterns achieve self-sufficiency most easily. Multi-family buildings with conventional electricity demand and rural mobility patterns can only be self-sufficient if PV efficiency increases, and all of the roof plus most of the facade can be covered with PV. All self-sufficient cases are technically feasible but more expensive than fully electrified grid-connected cases. Self-sufficiency may even become cost-competitive in some cases depending on storage and fossil fuel prices. Thus, if political measures improve their financial attractiveness or individuals decide to shoulder the necessary investments, self-sufficient buildings may start to become increasingly prevalent.


Assuntos
Poluição do Ar/prevenção & controle , Clima , Indústria da Construção/métodos , Fontes de Energia Elétrica/economia , Semicondutores/economia , Automóveis/economia , Mudança Climática , Indústria da Construção/economia , Indústria da Construção/tendências , Fontes de Energia Elétrica/tendências , Eletrólise/economia , Estudos de Viabilidade , Combustíveis Fósseis/efeitos adversos , Humanos , Hidrogênio/química , Hidrogênio/economia , Lítio/química , Lítio/economia , Densidade Demográfica , Suíça
18.
Occup Environ Med ; 77(4): 238-248, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32019845

RESUMO

OBJECTIVE: This study evaluated the relationship between brain and other central nervous system cancer ('CNS cancer') and exposures at two semiconductor and electronic module manufacturing facilities and at a storage device manufacturing facility. METHODS: The case-control study, nested in a cohort of 126 836 employees, compared 120 CNS cancer cases and 1028 matched controls with respect to employment in 10 process groups and estimated cumulative exposure to 31 known or possible carcinogens. RESULTS: CNS cancer was associated with module manufacturing operations at two facilities. Module manufacturing is a process that begins with production of ceramic substrates followed by attachment of completed semiconductor chips and metal-containing circuitry resulting in a high performing electronic device. Positive associations with the highest tertile of estimated cumulative exposure were found for several chemicals, including 2-butoxyethanol, cyclohexanone, ortho-dichlorobenzene, cadmium, molybdenum, trichloroethylene and vinyl chloride. CONCLUSIONS: Results suggested positive associations between CNS cancer and specific operations and chemicals experienced in the semiconductor and electronic module manufacturing industry. However, lack of external support for these findings precludes a causal interpretation, and the observed associations may have been due to chance.


Assuntos
Neoplasias do Sistema Nervoso Central/induzido quimicamente , Neoplasias do Sistema Nervoso Central/mortalidade , Doenças Profissionais/induzido quimicamente , Doenças Profissionais/mortalidade , Exposição Ocupacional/efeitos adversos , Semicondutores/efeitos adversos , Neoplasias Encefálicas , Estudos de Casos e Controles , Monitoramento Ambiental , Humanos , Indústria Manufatureira , Instalações Industriais e de Manufatura , Compostos Orgânicos/efeitos adversos , Sistema de Registros , Estados Unidos/epidemiologia
19.
Biochemistry (Mosc) ; 85(Suppl 1): S196-S212, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32087060

RESUMO

Rhodopsins are light-sensitive membrane proteins enabling transmembrane charge separation (proton pump) on absorption of a light quantum. Bacteriorhodopsin (BR) is a transmembrane protein from halophilic bacteria that belongs to the rhodopsin family. Potential applications of BR are considered so promising that the number of studies devoted to the use of BR itself, its mutant variants, as well as hybrid materials containing BR in various areas grows steadily. Formation of hybrid structures combining BR with nanoparticles is an essential step in promotion of BR-based devices. However, rapid progress, continuous emergence of new data, as well as challenges of analyzing the entire data require regular reviews of the achievements in this area. This review is devoted to the issues of formation of materials based on hybrids of BR with fluorescent semiconductor nanocrystals (quantum dots) and with noble metal (silver, gold) plasmonic nanoparticles. Recent data on formation of thin (mono-) and thick (multi-) layers from materials containing BR and BR/nanoparticle hybrids are presented.


Assuntos
Bacteriorodopsinas/química , Bacteriorodopsinas/fisiologia , Nanopartículas Metálicas/química , Pontos Quânticos/química , Campos Eletromagnéticos , Ouro/química , Ouro/metabolismo , Halobacterium salinarum/citologia , Membrana Purpúrea/metabolismo , Células Fotorreceptoras Retinianas Bastonetes/metabolismo , Rodopsina/química , Semicondutores , Prata/química , Prata/metabolismo , Análise Espectral Raman
20.
Chem Commun (Camb) ; 56(20): 3035-3038, 2020 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-32048636

RESUMO

It remains challenging to develop new materials exhibiting enzyme-like activities and understand the structure-property correlations and catalytic mechanisms. In this study, the characteristics, mechanisms, and applications of a light-activated mimic oxidase based on semiconducting polymer dots (Pdots) prepared from an organic conjugated polymer are demonstrated.


Assuntos
Luz , Polímeros/química , Pontos Quânticos/química , Materiais Biomiméticos/química , Materiais Biomiméticos/metabolismo , Catálise , Estrutura Molecular , Oxirredutases/química , Oxirredutases/metabolismo , Semicondutores
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA