Detalhe da pesquisa
1.
Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors.
Bioorg Med Chem
; 23(10): 2424-34, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25868746
2.
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity.
Bioorg Med Chem Lett
; 22(10): 3544-9, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22503250
3.
Bioisosteric approach to the discovery of imidazo[1,2-a]pyrazines as potent Aurora kinase inhibitors.
Bioorg Med Chem Lett
; 21(1): 592-8, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21075632
4.
Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain.
Biochemistry
; 49(38): 8350-8, 2010 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20718440
5.
Expression, purification, stability optimization and characterization of human Aurora B kinase domain from E. coli.
Arch Biochem Biophys
; 503(2): 191-201, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20699085
6.
Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.
Bioorg Med Chem Lett
; 20(17): 5170-4, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20674350
7.
Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.
Bioorg Med Chem Lett
; 20(22): 6739-43, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855207
8.
Label-Free, LC-MS-Based Assays to Quantitate Small-Molecule Antagonist Binding to the Mammalian BLT1 Receptor.
SLAS Discov
; 22(9): 1131-1141, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28763622
9.
Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3'-kinase-AKT-dependent pathway.
Cancer Res
; 62(11): 3132-7, 2002 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12036925
10.
Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol.
Cancer Res
; 63(9): 2139-44, 2003 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12727831
11.
Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.
Oncogene
; 21(8): 1159-66, 2002 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-11850835
12.
Structural basis of CX-4945 binding to human protein kinase CK2.
FEBS Lett
; 585(1): 104-10, 2011 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21093442
13.
SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors.
Cancer Chemother Pharmacol
; 68(4): 923-33, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21298383
14.
Aurora kinase inhibitors based on the imidazo[1,2-a]pyrazine core: fluorine and deuterium incorporation improve oral absorption and exposure.
J Med Chem
; 54(1): 201-10, 2011 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21128646
15.
SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics.
Mol Cancer Ther
; 9(11): 2993-3002, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20978164
16.
Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core.
ACS Med Chem Lett
; 1(5): 214-8, 2010 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900197
17.
Enhancement of the antitumor activity of tamoxifen and anastrozole by the farnesyltransferase inhibitor lonafarnib (SCH66336).
Anticancer Drugs
; 18(8): 923-31, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17667598
18.
Inhibition of cyclin-dependent kinases - a review of the recent patent literature.
Recent Pat Anticancer Drug Discov
; 1(3): 357-67, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18221046
19.
Lipid posttranslational modifications. Farnesyl transferase inhibitors.
J Lipid Res
; 47(1): 15-31, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16278491
20.
The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.
J Biol Chem
; 280(35): 31101-8, 2005 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16006564