Detalhe da pesquisa
1.
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate.
J Med Chem
; 65(3): 2262-2287, 2022 02 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34995458
2.
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression.
J Med Chem
; 64(16): 12200-12227, 2021 08 26.
Artigo
Inglês
| MEDLINE | ID: mdl-34387088
3.
Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain.
Bioorg Med Chem Lett
; 20(15): 4683-8, 2010 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20566291
4.
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.
J Med Chem
; 63(2): 714-746, 2020 01 23.
Artigo
Inglês
| MEDLINE | ID: mdl-31904959
5.
Novel methylene-linked heterocyclic EP1 receptor antagonists.
Bioorg Med Chem Lett
; 18(5): 1592-7, 2008 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18262416
6.
Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.
J Med Chem
; 59(3): 1003-20, 2016 Feb 11.
Artigo
Inglês
| MEDLINE | ID: mdl-26751273
7.
Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.
J Med Chem
; 59(4): 1425-39, 2016 Feb 25.
Artigo
Inglês
| MEDLINE | ID: mdl-25856009
8.
Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists.
J Med Chem
; 58(20): 8236-56, 2015 Oct 22.
Artigo
Inglês
| MEDLINE | ID: mdl-26393276
9.
Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles.
J Med Chem
; 57(24): 10424-42, 2014 Dec 26.
Artigo
Inglês
| MEDLINE | ID: mdl-25431977
10.
Discovery of a brain-penetrant S1P3-sparing direct agonist of the S1P1 and S1P5 receptors efficacious at low oral dose.
J Med Chem
; 54(19): 6724-33, 2011 Oct 13.
Artigo
Inglês
| MEDLINE | ID: mdl-21838322
11.
Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate.
ACS Med Chem Lett
; 2(6): 444-9, 2011 Jun 09.
Artigo
Inglês
| MEDLINE | ID: mdl-24900328
12.
The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain.
Bioorg Med Chem Lett
; 17(2): 385-9, 2007 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17084082
13.
Discovery of novel biaryl heterocyclic EP1 receptor antagonists.
Bioorg Med Chem Lett
; 16(10): 2666-71, 2006 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16503138
14.
Structure-based design of peptidomimetic antagonists of p56(lck) SH2 domain.
Bioorg Med Chem Lett
; 12(10): 1365-9, 2002 May 20.
Artigo
Inglês
| MEDLINE | ID: mdl-11992778