Pesquisa | Secretaria de Estado da Saúde

1.

A Designed Host Defense Peptide for the Topical Treatment of MRSA-Infected Diabetic Wounds.

Vargas, Alex; Garcia, Gustavo; Rivara, Kathryn; Woodburn, Kathryn; Clemens, Louis Edward; Simon, Scott I.

Int J Mol Sci ; 24(3)2023 Jan 21.

Artigo Inglês | MEDLINE | ID: mdl-36768463

2.

An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes.

Hernandez, Alfredo A; Foster, Greg A; Soderberg, Stephanie R; Fernandez, Andrea; Reynolds, Mack B; Orser, Mable K; Bailey, Keith A; Rogers, Jason H; Singh, Gagan D; Wu, Huaizhu; Passerini, Anthony G; Simon, Scott I.

J Immunol ; 205(10): 2806-2820, 2020 11 15.

Artigo Inglês | MEDLINE | ID: mdl-33055281

3.

Clonal VÎ³6⁺VÎ´4⁺ T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection.

Marchitto, Mark C; Dillen, Carly A; Liu, Haiyun; Miller, Robert J; Archer, Nathan K; Ortines, Roger V; Alphonse, Martin P; Marusina, Alina I; Merleev, Alexander A; Wang, Yu; Pinsker, Bret L; Byrd, Angel S; Brown, Isabelle D; Ravipati, Advaitaa; Zhang, Emily; Cai, Shuting S; Limjunyawong, Nathachit; Dong, Xinzhong; Yeaman, Michael R; Simon, Scott I; Shen, Wei; Durum, Scott K; O'Brien, Rebecca L; Maverakis, Emanual; Miller, Lloyd S.

Proc Natl Acad Sci U S A ; 116(22): 10917-10926, 2019 05 28.

Artigo Inglês | MEDLINE | ID: mdl-31088972

4.

Replacing Saturated Fat With Unsaturated Fat in Western Diet Reduces Foamy Monocytes and Atherosclerosis in Male Ldlr^-/- Mice.

Lian, Zeqin; Perrard, Xiao-Yuan Dai; Peng, Xueying; Raya, Joe L; Hernandez, Alfredo A; Johnson, Collin G; Lagor, William R; Pownall, Henry J; Hoogeveen, Ron C; Simon, Scott I; Sacks, Frank M; Ballantyne, Christie M; Wu, Huaizhu.

Arterioscler Thromb Vasc Biol ; 40(1): 72-85, 2020 01.

Artigo Inglês | MEDLINE | ID: mdl-31619061

5.

IRF-1 mediates the suppressive effects of mTOR inhibition on arterial endothelium.

Peng, Kai; Fan, Xing; Li, Qiannan; Wang, Yiying; Chen, Xiaolin; Xiao, Pingxi; Passerini, Anthony G; Simon, Scott I; Sun, ChongXiu.

J Mol Cell Cardiol ; 140: 30-41, 2020 03.

Artigo Inglês | MEDLINE | ID: mdl-32087218

6.

Mechanoregulation of p38 activity enhances endoplasmic reticulum stress-mediated inflammation by arterial endothelium.

Bailey, Keith A; Moreno, Emily; Haj, Fawaz G; Simon, Scott I; Passerini, Anthony G.

FASEB J ; 33(11): 12888-12899, 2019 11.

Artigo Inglês | MEDLINE | ID: mdl-31499005

7.

Downregulation of GATA6 in mTOR-inhibited human aortic endothelial cells: effects on TNF-α-induced VCAM-1 expression and monocytic cell adhesion.

Fan, Xing; Chen, Xiaolin; Feng, Qi; Peng, Kai; Wu, Qianqian; Passerini, Anthony G; Simon, Scott I; Sun, ChongXiu.

Am J Physiol Heart Circ Physiol ; 316(2): H408-H420, 2019 02 01.

Artigo Inglês | MEDLINE | ID: mdl-30462552

8.

Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow.

Morikis, Vasilios A; Chase, Shannon; Wun, Ted; Chaikof, Elliot L; Magnani, John L; Simon, Scott I.

Blood ; 130(19): 2101-2110, 2017 11 09.

Artigo Inglês | MEDLINE | ID: mdl-28811304

9.

α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds.

Falahee, Patrick C; Anderson, Leif S; Reynolds, Mack B; Pirir, Mauricio; McLaughlin, Bridget E; Dillen, Carly A; Cheung, Ambrose L; Miller, Lloyd S; Simon, Scott I.

J Immunol ; 199(5): 1772-1782, 2017 09 01.

Artigo Inglês | MEDLINE | ID: mdl-28733486

10.

Gnb isoforms control a signaling pathway comprising Rac1, Plcß2, and Plcß3 leading to LFA-1 activation and neutrophil arrest in vivo.

Block, Helena; Stadtmann, Anika; Riad, Daniel; Rossaint, Jan; Sohlbach, Charlotte; Germena, Giulia; Wu, Dianqing; Simon, Scott I; Ley, Klaus; Zarbock, Alexander.

Blood ; 127(3): 314-24, 2016 Jan 21.

Artigo Inglês | MEDLINE | ID: mdl-26468229

11.

Calcium signalling and related ion channels in neutrophil recruitment and function.

Immler, Roland; Simon, Scott I; Sperandio, Markus.

Eur J Clin Invest ; 48 Suppl 2: e12964, 2018 Nov.

Artigo Inglês | MEDLINE | ID: mdl-29873837

12.

Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids.

Murphy, Kaitlin C; Whitehead, Jacklyn; Falahee, Patrick C; Zhou, Dejie; Simon, Scott I; Leach, J Kent.

Stem Cells ; 35(6): 1493-1504, 2017 06.

Artigo Inglês | MEDLINE | ID: mdl-28276602

13.

You've got to be kindlin!

Simon, Scott I.

Blood ; 125(12): 1855-6, 2015 Mar 19.

Artigo Inglês | MEDLINE | ID: mdl-25792733

14.

CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia.

Foster, Greg A; Xu, Lu; Chidambaram, Alagu A; Soderberg, Stephanie R; Armstrong, Ehrin J; Wu, Huaizhu; Simon, Scott I.

J Immunol ; 195(11): 5380-92, 2015 Dec 01.

Artigo Inglês | MEDLINE | ID: mdl-26519532

15.

11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization.

Sun, Chongxiu; Simon, Scott I; Foster, Greg A; Radecke, Christopher E; Hwang, HyunTae V; Zhang, Xiaodong; Hammock, Bruce D; Chiamvimonvat, N; Knowlton, Anne A.

J Mol Cell Cardiol ; 94: 180-188, 2016 05.

Artigo Inglês | MEDLINE | ID: mdl-27079253

16.

Foamy monocytes form early and contribute to nascent atherosclerosis in mice with hypercholesterolemia.

Xu, Lu; Dai Perrard, Xiaoyuan; Perrard, Jerry L; Yang, Donglin; Xiao, Xinhua; Teng, Ba-Bie; Simon, Scott I; Ballantyne, Christie M; Wu, Huaizhu.

Arterioscler Thromb Vasc Biol ; 35(8): 1787-97, 2015 Aug.

Artigo Inglês | MEDLINE | ID: mdl-26112011

17.

Neutrophils in hot pursuit of MRSA in the lymph nodes.

Miller, Lloyd S; Simon, Scott I.

Proc Natl Acad Sci U S A ; 115(10): 2272-2274, 2018 03 06.

Artigo Inglês | MEDLINE | ID: mdl-29476009

18.

On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction.

Foster, Greg A; Gower, R Michael; Stanhope, Kimber L; Havel, Peter J; Simon, Scott I; Armstrong, Ehrin J.

Proc Natl Acad Sci U S A ; 110(34): 13944-9, 2013 Aug 20.

Artigo Inglês | MEDLINE | ID: mdl-23918401

19.

Mechanosensing at the vascular interface.

Tarbell, John M; Simon, Scott I; Curry, Fitz-Roy E.

Annu Rev Biomed Eng ; 16: 505-32, 2014 Jul 11.

Artigo Inglês | MEDLINE | ID: mdl-24905872

20.

Gimme a brake: HPK1 regulates LFA-1 and neutrophil traction.