Detalhe da pesquisa
1.
Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold.
Bioorg Med Chem Lett
; 20(22): 6754-7, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20869872
2.
Scintillation proximity assays for mechanistic and pharmacological analyses of HIV-1 integration.
Methods
; 47(4): 249-53, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19285556
3.
Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 18(2): 721-5, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18078751
4.
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Bioorg Med Chem Lett
; 18(19): 5307-10, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18774711
5.
10-Hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants.
Bioorg Med Chem Lett
; 18(16): 4581-3, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18657970
6.
Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.
J Med Chem
; 50(9): 2225-39, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17428043
7.
Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.
J Med Chem
; 50(20): 4953-75, 2007 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17824681
8.
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
J Med Chem
; 46(4): 453-6, 2003 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12570367
9.
Dissecting Tn5 transposition using HIV-1 integrase diketoacid inhibitors.
Biochemistry
; 46(38): 10776-89, 2007 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-17725323
10.
From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety.
Bioorg Med Chem Lett
; 17(2): 350-3, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17107799
11.
A potent and orally active HIV-1 integrase inhibitor.
Bioorg Med Chem Lett
; 17(5): 1392-8, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17194584
12.
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 16(11): 2900-4, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16554152
13.
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
Bioorg Med Chem Lett
; 15(20): 4550-4, 2005 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16102965
14.
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
Proc Natl Acad Sci U S A
; 101(31): 11233-8, 2004 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15277684