Detalhe da pesquisa
1.
Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold.
Bioorg Med Chem Lett
; 20(22): 6754-7, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20869872
2.
Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 18(2): 721-5, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18078751
3.
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Bioorg Med Chem Lett
; 18(19): 5307-10, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18774711
4.
10-Hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants.
Bioorg Med Chem Lett
; 18(16): 4581-3, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18657970
5.
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
J Med Chem
; 46(4): 453-6, 2003 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12570367
6.
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.
J Med Chem
; 51(18): 5843-55, 2008 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18763751
7.
A potent and orally active HIV-1 integrase inhibitor.
Bioorg Med Chem Lett
; 17(5): 1392-8, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17194584
8.
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
Bioorg Med Chem Lett
; 15(20): 4550-4, 2005 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16102965
9.
Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques.
Science
; 305(5683): 528-32, 2004 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15247437
10.
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
Proc Natl Acad Sci U S A
; 101(31): 11233-8, 2004 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15277684