Efeito pró-erétil em ratos tratados com extrato etanólico das vagens de Senna spectabilis / Pro-erectile effect in rats treated with ethanol extract of pods of Senna spectabilis

This study aimed analize the Pro-erectile effect of rats trated with ethanol extract os pods of Sennaspectabilis (EEVSs), a native plant from Savana, predominant on brazilian northwest. Compreendendo que Thefeed is an important aspect for the development of good breeders and reproductive risk of failures caused byempirical use of native plants in the feeding of cattle can not be ignoredWere used 40 Wistar rats separated inthree groups treated with EEVSs and one group treated with apomorphine and another treated with distilledwater. After each treatment the animals were observed In a transparent chamber. The rats that received theEEVSs showed no significant alterations. However at presence of apomorphine there was an increase of penileerection, for it is an dopaminergic agonist.(AU)

Avaliação do ciclo estral e da toxicidade sistêmica do látex de Himatanthus sucuuba (Spruce) Woodson em ratas Wistar / The estrous cycle evaluation and systemic toxicity in the latex of Himatanthus sucuuba (Spruce) Woodson in Wistar rats

It aimed to investigate the possible effects induced by the diluted latex oral administration of H. sucuuba(LdHs) in Wistar rats on the estrous cycle and other organ systems. The Wistar rats received by gavage the LdHs.The results showed that there was a decrease in average daily intake and ponderable development negativeinterference in the group treated with the dose 100 mg / kg. The number of primary follicles and in the dose 100 mg/ kg LdHs was superior to the control group. It was also observed a decrease in the number of estrous cycles andan increase in the average duration of the estrous cycle in this group. Therefore, doses 25 and 50 mg / kg of LdHshave been shown safe, however the dose 100 mg / kg decreased reproductive efficiency and promoted a lowsystemic toxicity as caused a decrease in feed consumption and interfered with the ponderable development.(AU)

Pesquisa de atividade androgênica e antiandrogênica em ratos tratados com extrato etanólico das vagens de Senna spectabilis / Evaluation of Androgenic and antiandrogenic activity in rats treated with ethanol extract of pods of Senna spectabilis

Although the high expression of the northeastern herds, the levels of productivity, reproducibility,carcass gain and other factors are low. This is mainly due to the main food source being from native plants ofthe Savanna. Were used male Wistar rats (64) divided into eight groups. These animals were castrated and, afterrecovery, received ethanol extract of pods of Senna spectabilis (EEVSs) in three different doses and testosteroneintramuscularly (some groups). The animals were treated for 32 consecutive days and at the end wereeuthanized. The organs were collected and weighed for evaluation of androgenic and anti-androgenic activity.The extract showed no androgenic nor anti-androgenic activity at the doses tested.(AU)

Avaliação da toxicidade gestacional do látex de Himatanthus sucuuba (Spruce) Woodson m camundongos fêmeas Swiss e avaliação da progênie / Evaluation of gestational toxicity of latex of Himatanthus sucuuba (Spruce) Woodson in the female Swiss mice and evaluation of progeny

It aimed to investigate the possible effects of the oral administration of the latex diluted of H. sucuuba(LdHs) on pregnancy in the female Swiss mice and evaluation of progeny. We used 54 female mice pregnantwomen in the evaluation protocol gestational toxicity and progeny. Females received the LdHs by gavage during8th to 12th day of gestation and during late pregnancy were euthanized for the observation of gestationalparameters and evaluation of the fetuses. None of LdHs doses interfered negatively on gestational parametersinvestigated or ossification of fetuses, and also did not cause visceral malformations in the offspring. Therefore, thetested doses of LdHs did not cause gestational toxicity in female mice as well as did not interfere in the progeny.(AU)

Avaliação da toxicidade gestacional do látex de Himatanthus sucuuba (Spruce) Woodson m camundongos fêmeas Swiss e avaliação da progênie / Evaluation of gestational toxicity of latex of Himatanthus sucuuba (Spruce) Woodson in the female Swiss mice and evaluation of progeny

It aimed to investigate the possible effects of the oral administration of the latex diluted of H. sucuuba(LdHs) on pregnancy in the female Swiss mice and evaluation of progeny. We used 54 female mice pregnantwomen in the evaluation protocol gestational toxicity and progeny. Females received the LdHs by gavage during8th to 12th day of gestation and during late pregnancy were euthanized for the observation of gestationalparameters and evaluation of the fetuses. None of LdHs doses interfered negatively on gestational parametersinvestigated or ossification of fetuses, and also did not cause visceral malformations in the offspring. Therefore, thetested doses of LdHs did not cause gestational toxicity in female mice as well as did not interfere in the progeny.

Avaliação do ciclo estral e da toxicidade sistêmica do látex de Himatanthus sucuuba (Spruce) Woodson em ratas Wistar / The estrous cycle evaluation and systemic toxicity in the latex of Himatanthus sucuuba (Spruce) Woodson in Wistar rats

It aimed to investigate the possible effects induced by the diluted latex oral administration of H. sucuuba(LdHs) in Wistar rats on the estrous cycle and other organ systems. The Wistar rats received by gavage the LdHs.The results showed that there was a decrease in average daily intake and ponderable development negativeinterference in the group treated with the dose 100 mg / kg. The number of primary follicles and in the dose 100 mg/ kg LdHs was superior to the control group. It was also observed a decrease in the number of estrous cycles andan increase in the average duration of the estrous cycle in this group. Therefore, doses 25 and 50 mg / kg of LdHshave been shown safe, however the dose 100 mg / kg decreased reproductive efficiency and promoted a lowsystemic toxicity as caused a decrease in feed consumption and interfered with the ponderable development.

Pesquisa de atividade androgênica e antiandrogênica em ratos tratados com extrato etanólico das vagens de Senna spectabilis / Evaluation of Androgenic and antiandrogenic activity in rats treated with ethanol extract of pods of Senna spectabilis

Although the high expression of the northeastern herds, the levels of productivity, reproducibility,carcass gain and other factors are low. This is mainly due to the main food source being from native plants ofthe Savanna. Were used male Wistar rats (64) divided into eight groups. These animals were castrated and, afterrecovery, received ethanol extract of pods of Senna spectabilis (EEVSs) in three different doses and testosteroneintramuscularly (some groups). The animals were treated for 32 consecutive days and at the end wereeuthanized. The organs were collected and weighed for evaluation of androgenic and anti-androgenic activity.The extract showed no androgenic nor anti-androgenic activity at the doses tested.

Efeito pró-erétil em ratos tratados com extrato etanólico das vagens de Senna spectabilis / Pro-erectile effect in rats treated with ethanol extract of pods of Senna spectabilis

This study aimed analize the Pro-erectile effect of rats trated with ethanol extract os pods of Sennaspectabilis (EEVSs), a native plant from Savana, predominant on brazilian northwest. Compreendendo que Thefeed is an important aspect for the development of good breeders and reproductive risk of failures caused byempirical use of native plants in the feeding of cattle can not be ignoredWere used 40 Wistar rats separated inthree groups treated with EEVSs and one group treated with apomorphine and another treated with distilledwater. After each treatment the animals were observed In a transparent chamber. The rats that received theEEVSs showed no significant alterations. However at presence of apomorphine there was an increase of penileerection, for it is an dopaminergic agonist.

Avaliação da toxicidade crônica e gestacional do extrato etanólico de Buchenavia sp., em ratas Wistar / Assessment of chronic toxicity and gestational ethanol extract of Buchenavia sp. In Wistar rats

Com o objetivo de avaliar os possíveis efeitos tóxicos sistêmicos e reprodutivos do extrato etanólico de Buchenavia sp. (EEtOH-B), em ratas e sua prole, foram executados os protocolos gestacionais de pré-implantação, com 8 dias de tratamento, e pós-implantação, com 34 dias de administração, desde o 8º dia gestacional até o desmame e a avaliação da prole, e por fim, o protocolo de toxicidade crônica com 30 dias de tratamento. Em todos os protocolos, as ratas receberam o extrato etanólico nas dosagens de 250, 500 e 1000 mg/kg/dia (n=8/grupo) e para cada protocolo foi instituído um grupo controle (n=8/grupo) no qual foi administrada água destilada (10ml/kg/dia). Os resultados mostram que durante o período de realização dos tratamentos, não foram observados efeitos nocivos significativos ou óbitos que pudessem ser atribuídos ao extrato utilizado. Concluiu-se que o EEtOH-B não induz abortamento em ratas.

In order to evaluate the possible systemic and reproductive toxicity of the ethanol extractof Buchenavia sp., (EEtOH-B) in rats andt heir offspring, were executed protocols gestational pre-deployment, with 8 days of treatment, and post-implantation, with 34 days of administration, provided for the 8th gestational day until weaning and evaluation offspring, and finally, the protocol of chronic toxicity with 30 days of treatment. In all protocols, rats received the ethanol extract at doses of 250, 500 and 1000 mg/kg/day (n=8/group) and for each protocol was established as a control group (n=8/group) in which it was administered distilled water (10ml/kg/day). The results show that during both treatments were not observed any significant adverse effects or deaths that could be attributed to the extract used. It was concluded tha the EEtOH-B does not induce abortion in female rats.

Avaliação da toxicidade crônica e gestacional do extrato etanólico de Buchenavia sp., em ratas Wistar / Assessment of chronic toxicity and gestational ethanol extract of Buchenavia sp. In Wistar rats

Com o objetivo de avaliar os possíveis efeitos tóxicos sistêmicos e reprodutivos do extrato etanólico de Buchenavia sp. (EEtOH-B), em ratas e sua prole, foram executados os protocolos gestacionais de pré-implantação, com 8 dias de tratamento, e pós-implantação, com 34 dias de administração, desde o 8º dia gestacional até o desmame e a avaliação da prole, e por fim, o protocolo de toxicidade crônica com 30 dias de tratamento. Em todos os protocolos, as ratas receberam o extrato etanólico nas dosagens de 250, 500 e 1000 mg/kg/dia (n=8/grupo) e para cada protocolo foi instituído um grupo controle (n=8/grupo) no qual foi administrada água destilada (10ml/kg/dia). Os resultados mostram que durante o período de realização dos tratamentos, não foram observados efeitos nocivos significativos ou óbitos que pudessem ser atribuídos ao extrato utilizado. Concluiu-se que o EEtOH-B não induz abortamento em ratas.(AU)

In order to evaluate the possible systemic and reproductive toxicity of the ethanol extractof Buchenavia sp., (EEtOH-B) in rats andt heir offspring, were executed protocols gestational pre-deployment, with 8 days of treatment, and post-implantation, with 34 days of administration, provided for the 8th gestational day until weaning and evaluation offspring, and finally, the protocol of chronic toxicity with 30 days of treatment. In all protocols, rats received the ethanol extract at doses of 250, 500 and 1000 mg/kg/day (n=8/group) and for each protocol was established as a control group (n=8/group) in which it was administered distilled water (10ml/kg/day). The results show that during both treatments were not observed any significant adverse effects or deaths that could be attributed to the extract used. It was concluded tha the EEtOH-B does not induce abortion in female rats.(AU)