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Braz. j. med. biol. res ; 54(2): e9017, 2021. graf
Artigo em Inglês | LILACS-Express | LILACS, Coleciona SUS | ID: biblio-1142574


The purpose of this study was to investigate the anti-cancer effect of melittin on growth, migration, invasion, and apoptosis of non-small-cell lung cancer (NSCLC) cells. This study also explored the potential anti-cancer mechanism of melittin in NSCLC cells. The results demonstrated that melittin suppressed growth, migration, and invasion, and induced apoptosis of NSCLC cells in vitro. Melittin increased pro-apoptotic caspase-3 and Apaf-1 gene expression. Melittin inhibited tumor growth factor (TGF)-β expression and phosphorylated ERK/total ERK (pERK/tERK) in NSCLC cells. However, TGF-β overexpression (pTGF-β) abolished melittin-decreased TGF-β expression and pERK/tERK in NSCLC cells. Treatment with melittin suppressed tumor growth and prolonged mouse survival during the 120-day observation in vivo. Treatment with melittin increased TUNEL-positive cells and decreased expression levels of TGF-β and ERK in tumor tissue compared to the control group. In conclusion, the findings of this study indicated that melittin inhibited growth, migration, and invasion, and induced apoptosis of NSCLC cells through down-regulation of TGF-β-mediated ERK signaling pathway, suggesting melittin may be a promising anti-cancer agent for NSCLC therapy.

Braz. j. med. biol. res ; 54(2): e9549, 2021. tab, graf
Artigo em Inglês | LILACS-Express | LILACS, Coleciona SUS | ID: biblio-1142579


Single nucleotide polymorphisms (SNPs) have important application value in the research of population genetics, hereditary diseases, tumors, and drug development. Conventional methods for detecting SNPs are typically based on PCR or DNA sequencing, which is time-consuming, costly, and requires complex instrumentation. In this study, we present a duplex probe-directed recombinase amplification (duplex-PDRA) assay that can perform real-time detection of two SNPs (rs6983267 and rs1447295) in four reactions in two tubes at 39°C within 30 min. The sensitivity of duplex-PDRA was 2×103-104 copies per reaction and no cross-reactivity was observed. A total of 382 clinical samples (179 prostate cancer patients and 203 controls) from northern China were collected and tested by duplex-PDRA assay and direct sequencing. The genotyping results were completely identical. In addition, the association analysis of two SNPs with prostate cancer risk and bone metastasis was conducted. We found that the TT genotype of rs6983267 (OR: 0.42; 95%CI: 0.23-0.78; P=0.005) decreased the risk of prostate cancer, while the CA genotype of rs1447295 (OR: 1.89; 95%CI: 1.20-2.96; P=0.005) increased the risk of prostate cancer. However, no association between the two SNPs (rs6983267 and rs1447295) and bone metastasis in prostate cancer was found in this study (P>0.05). In conclusion, the duplex-PDRA assay is an effective method for the simultaneous detection of two SNPs and shows great potential for widespread use in research and clinical settings.

Braz. j. med. biol. res ; 54(2): e9869, 2021. tab, graf
Artigo em Inglês | LILACS-Express | LILACS, Coleciona SUS | ID: biblio-1142585


Severe blockage in myeloid differentiation is the hallmark of acute myeloid leukemia (AML). Trdmt1 plays an important role in hematopoiesis. However, little is known about the function of Trdmt1 in AML cell differentiation. In the present study, Trdmt1 was up-regulated and miR-181a was down-regulated significantly during human leukemia HL-60 cell differentiation after TAT-CT3 fusion protein treatment. Accordingly, miR-181a overexpression in HL-60 cells inhibited granulocytic maturation. In addition, our "rescue" assay demonstrated that Trdmt1 3′-untranslated region promoted myeloid differentiation of HL-60 cells by sequestering miR-181a and up-regulating C/EBPα (a critical factor for normal myelopoiesis) via its competing endogenous RNA (ceRNA) activity on miR-181a. These findings revealed an unrecognized role of Trdmt1 as a potential ceRNA for therapeutic targets in AML.

Braz. j. med. biol. res ; 54(2): e9173, 2021. tab, graf
Artigo em Inglês | LILACS-Express | LILACS, Coleciona SUS | ID: biblio-1142586


This study aimed to explore the correlation of kinesin family member 2A (KIF2A) expression with disease risk, clinical characteristics, and prognosis of acute myeloid leukemia (AML), and investigate the effect of KIF2A knockdown on AML cell activities in vitro. Bone marrow samples were collected from 176 AML patients and 40 healthy donors, and KIF2A expression was measured by real-time quantitative polymerase chain reaction. Treatment response, event-free survival (EFS), and overall survival (OS) were assessed in AML patients. In vitro, KIF2A expression in AML cell lines and CD34+ cells (from healthy donors) was measured, and the effect of KIF2A knockdown on AML cell proliferation and apoptosis in HL-60 and KG-1 cells was detected. KIF2A expression was greater in AML patients compared to healthy donors, and receiver operating characteristic curve indicated that KIF2A expression predicted increased AML risk (area under curve: 0.793 (95%CI: 0.724-0.826)). In AML patients, KIF2A expression positively correlated with white blood cells, monosomal karyotype, and high risk stratification. Furthermore, no correlation of KIF2A expression with complete remission or hematopoietic stem cell transplantation was found. Kaplan-Meier curves showed that KIF2A expression was negatively correlated with EFS and OS. In vitro experiments showed that KIF2A was overexpressed in AML cell lines (KG-1, HL-60, ME-1, and HT-93) compared to CD34+ cells, moreover, cell proliferation was reduced but apoptosis was increased by KIF2A knockdown in HL-60 and KG-1 cells. In conclusion, KIF2A showed potential to be a biomarker and treatment target in AML.

Epidemiol. serv. saúde ; 30(1): e2020750, 2021. tab, graf
Artigo em Português | LILACS-Express | LILACS, Coleciona SUS, Sec. Est. Saúde SP | ID: biblio-1142937


Resumo Objetivo Descrever o perfil clínico-epidemiológico dos casos suspeitos de COVID-19 internados em hospital federal do Rio de Janeiro, RJ, Brasil, e identificar fatores associados ao óbito. Métodos Estudo seccional, utilizando dados da vigilância epidemiológica local até a Semana Epidemiológica 27 de 2020. Empregou-se regressão logística. Resultados Foram incluídos 376 casos internados suspeitos de COVID-19, dos quais 52,9% eram mulheres, 57,4% tinham 50 anos ou mais de idade e 80,1% exibiam comorbidades. Foram confirmados para COVID-19 195 casos (51,9%), cuja letalidade (37,9%) foi maior, comparada à dos descartados (24,2%). Na análise ajustada, associaram-se ao óbito, nos casos confirmados, ter 50 a 69 (OR=11,65 - IC95% 1,69;80,33) e 70 ou mais anos (OR=8,43 - IC95% 1,22;58,14), apresentar neoplasia (OR=4,34 - IC95% 1,28;14,76) e usar suporte ventilatório invasivo (OR=70,20 - IC95% 19,09;258,19). Conclusão Houve elevada prevalência de comorbidades e letalidade; os principais fatores associados ao óbito foram idade, presença de neoplasia e suporte ventilatório invasivo.

Resumen Objetivo Describir el perfil clínico-epidemiológico de casos sospechosos de COVID-19 ingresados en hospital federal de Río de Janeiro, RJ, Brasil, y factores asociados al óbito. Métodos Estudio transversal utilizando datos de la vigilancia epidemiológica local de casos sospechosos hospitalizados hasta la Semana Epidemiológica 27 de 2020 y regresión logística. Resultados Se incluyeron 376 casos, de los cuales 52,9% era de mujeres, 57,4% tenía 50 años o más, 80,1% tenía comorbilidades. Se confirmó para COVID-19 un 51,9% . Los casos confirmados tuvieron una mayor letalidad (37,9%) que los descartados (24,2%). La mortalidad ajustada en los confirmados fue mayor en los grupos de edad de 50 a 69 años (OR=11,65 - IC95% 1,69; 80,33), 70 años o más (OR=8,43 - IC95% 1,22;58,14), con neoplasia (OR=4,34 - IC95% 1,28;14,76) y uso de soporte ventilatorio invasivo (OR=70,20 - IC95% 19,09;258,19). Conclusión La mayor mortalidad se asoció con personas de edad avanzada, con neoplasias y uso de soporte ventilatorio invasivo.

Abstract Objective To describe the clinical and epidemiological profile of suspected COVID-19 cases admitted to a federal hospital in Rio de Janeiro, RJ, Brazil, and to identify factors associated with death. Methods This was a cross-sectional study using local epidemiological surveillance data as at epidemiological week 27 of 2020 and logistic regression. Results 376 hospitalized suspected COVID-19 cases were included; 52.9% were female, 57.4% were 50 years old or over and 80.1% had comorbidities. 195 (51.9%) COVID-19 cases were confirmed and their lethality was higher (37.9%) than among discarded cases (24.2%). In the adjusted analysis, death among confirmed cases was associated with being in the 50-69 age group (OR=11.65 - 95%CI 1.69;80.33), being aged 70 or over (OR=8.43 - 95%CI 1.22;58.14), presence of neoplasms (OR=4.34 - 95%CI 1.28;14.76) and use of invasive ventilatory support (OR=70.20 - 95%CI 19.09;258.19). Conclusion High prevalence of comorbidities and lethality was found; the main factors associated with death were being older, neoplasms and invasive ventilatory support.

Rev. Soc. Bras. Med. Trop ; 54: e20200143, 2021. graf
Artigo em Inglês | LILACS-Express | LILACS, Coleciona SUS, Sec. Est. Saúde SP | ID: biblio-1143881


Abstract Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.

Rio de Janeiro; s.n; 2021. ilus.
Tese em Português | Coleciona SUS | ID: biblio-1148238


Introdução: O pênfigo paraneoplásico é uma doença autoimune caracterizada pela produção de autoanticorpos por células tumorais neoplásicas. O primeiro sinal da doença são úlceras orais em 45% dos casos. Sua persistência e progressão são características de malignidade, reconhecida ou oculta. O difícil manejo dessa complicação, devido à doença de base não controlada, leva à piora dos sintomas e perda da qualidade de vida do doente. Objetivos: Relato de uma patologia rara, pouco relacionada a neoplasias sólidas, refratária a maioria dos tratamentos e com alta taxa de morbimortalidade. Métodos: Relato de caso de uma paciente com diagnóstico de carcinoma epidermoide de colo do útero, estadio IVa, com doença fora de controle e manifestações de pênfigo paraneoplásico cutâneo e mucoso. Resultados: A paciente apresentou o pênfigo paraneoplásico como complicação do câncer, com dificuldade de diagnóstico pela raridade da doença. Atualmente, sintomática com pouca resposta à corticoterapia. Conclusões: A raridade de algumas doenças torna o atraso no diagnóstico uma dificuldade ao tratamento. Assim como, o padrão de apresentação e a pouca experiência com patologias raras leva, muitas vezes, ao subdiagnóstico e subtratamento de nossos doentes, com perda da qualidade de vida

Background: Paraneoplastic pemphigus is an autoimmune disease characterized by autoantibody production by malignant tumor cells. The first sign of the disease is oral ulcer in 45% of cases. Their persistence and progression are features of malignancy, recognized or hidden. The difficult management of this complication due to uncontrolled underlying disease leads to the worsening of symptoms and loss of the patients' quality of life. Objective: Report a rare pathology, uncommonly related to solid neoplasms, refractory to most procedures and with high rates of morbidity and mortality. Methods: Case report of a patient diagnosed with squamous cell carcinoma of the cervix, stage IVa, with disease out of control and manifestations of skin and mucous paraneoplastic pemphigus. Results: The patient presented paraneoplastic pemphigus as a complication of the cancer, with a difficult diagnosis because of the rarity of the disease. Currently, symptomatic with little response to corticosteroid therapy. Conclusions: The uncommonness of some diseases makes the delay in diagnosing an obstacle to treatment. The presentation pattern and the little experience in rare diseases often lead to the underdiagnosis and undertreatment of our patients and loss of quality of life.

Humanos , Feminino , Adulto , Carcinoma de Células Escamosas/complicações , Pênfigo , Neoplasia Intraepitelial Cervical/complicações , Neoplasias
Brasília; CONASS; 2021. 342 p.
Monografia em Português | LILACS, Coleciona SUS, CONASS | ID: biblio-1150769


A Coleção COVID-19 apresenta em seus livros diferentes temas e debates. O Volume 5 ­ Acesso e Cuidados Especializados traz reflexões sobre a saúde pública e privada nos tempos da pandemia e suas respectivas interações, no âmbito dos cuidados especializados. Avança para os conteúdos relacionados à atuação da atenção especializada durante a pandemia, a abordagem clínica do paciente com a COVID-19, a atenção hospitalar em suas diferentes configurações: nas filantrópicas, nos hospitais universitários, nos hospitais de campanha e com a telemedicina. Os textos que seguem se preocupam com as comissões de controle de infecção e o cuidado seguro com os pacientes da COVID-19. Alcançam os cuidados paliativos e as diretivas antecipadas de vontade. Ultrapassados os conteúdos mais gerais, os textos passam a revelar sobre os cuidados com os pacientes com doença renal e oncológicos, até adentrarem na temática da assistência farmacêutica. Nesse campo, os debates comtemplam a escassez, o uso seguro, os casos do kit intubação e da Cloroquina/Hidroxicloroquina que ocuparam fortemente os noticiários brasileiros e que se revelaram problemas ímpares para a gestão em saúde. Por fim, o livro contempla os debates relacionados à pesquisa clínica, o registro sanitário de vacinas para a COVID-19 e a necessária sustentabilidade do SUS, pelo olhar de quem defende

Humanos , Pneumonia Viral/prevenção & controle , Sistema Único de Saúde/organização & administração , Infecções por Coronavirus/prevenção & controle , Pandemias/prevenção & controle , Monitoramento Epidemiológico , Brasil/epidemiologia , Políticas Públicas de Saúde , Iniquidade Social , Instituições Privadas de Saúde
Artigo em Português | LILACS, Coleciona SUS, CONASS, SES-GO | ID: biblio-1150728


O Ministério da Saúde em parceria com um dos hospitais de excelência do Brasil desenvolveu o Projeto Paciente Seguro pelo Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde, com o propósito de apoiar instituições na implementação do Programa Nacional de Segurança do Paciente. Este estudo tem como objetivo relatar a experiência da fase I do Projeto Paciente Seguro. Trata-se de um relato de experiência realizado no período de maio de 2016 a dezembro de 2017. A metodologia utilizada para implementar os protocolos foi o Modelo de Melhoria, o qual aplica testes rápidos em pequena escala para melhoria nos processos assistenciais. As intervenções realizadas permitiram identificar que compartilhar experiências, envolver a equipe assistencial e lideranças nos testes, foi fundamental para trabalhar a segurança do paciente nas instituições, obtendo uma redução de 100% em quedas e de 51,6% em lesão por pressão

The Ministry of Health in partnership with one of the hospitals of excellence in Brazil developed the Safe Patient Project through the Institutional Development Support Program of the Unified Health System, with the purpose of supporting institutions in the implementation of the National Patient Safety Program. This study aims to report the experience of phase I of the Safe Patient Project. This is an experience report carried out from May 2016 to December 2017. The methodology used to implement the protocols was the Improvement Model, which applies rapid tests on a small scale to improve care processes. The interventions made it possible to identify that sharing experiences, involving the assistance team and leadership in the tests, was fundamental to work on patient safety in the institutions, obtaining a reduction of 100% in falls and 51.6% in pressure injuries

Segurança do Paciente , Programas Nacionais de Saúde , Sistema Único de Saúde/organização & administração , Assistência ao Paciente/métodos
Rio de Janeiro; s.n; 2021.
Tese em Português | Coleciona SUS | ID: biblio-1152060


Foram coletados dados de 103 pacientes submetidas a histerectomia radical por via robótica para tratamento de câncer colo uterino inicial no Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA). A maioria da população era parda (51,5%). A mediana da idade em 41 anos. A mediana do tempo de internação em 1 dia. O IMC com mediana em 26,04. A maioria das pacientes foi submetida à histerectomia radical tipo III (46,6%), e à linfadenectomia pélvica em aproximadamente 95% dos casos. Houve 13,6% de complicação pós-operatória em 30 dias e a mais frequente foi a bexiga neurogênica. A curva de aprendizado dos cirurgiões não alterou o tempo cirúrgico, a sobrevida livre de doença e nem a sobrevida global. O tamanho tumoral teve impacto na frequência de recidiva, porém o tamanho estratificado em 2 cm não alterou a sobrevida global e sobrevida livre de doença.

We selected the medical records from 103 patients underwent to radical robotic hysterectomy for early cervical cancer at the Brazilian National Cancer Institute to conduct this review. We found that population was mostly brown (51.5%), median age was 41 years. The median length of stay was 1 day and median BMI was 26.04. Most patients underwent radical type III hysterectomy (46.6%), and pelvic lymphadenectomy was present in approximately 95% of cases. There were 13.6% of postoperative complications in 30 days and the most frequent was the neurogenic bladder. The surgeons' learning curve did not change the surgical time, nor did the disease-free survival and overall survival rate. The tumor size had an impact on recurrence frequency, but the stratified size at 2 cm did not change the overall survival and disease-free survival rate.

Humanos , Feminino , Adulto , Neoplasias do Colo do Útero , Procedimentos Cirúrgicos Robóticos , Histerectomia
An. bras. dermatol ; 95(6): 751-753, Nov.-Dec. 2020. graf
Artigo em Inglês | LILACS-Express | LILACS, Coleciona SUS | ID: biblio-1142116


Abstract Paget's disease is a rare disorder of the nipple and/or the areola that is characterized by an erythematosquamous lesion and is often associated with in situ or invasive breast carcinoma. The authors present an atypical, exuberant case that had evolved over eight years, emphasizing the importance of early diagnosis.

An. bras. dermatol ; 95(6): 728-730, Nov.-Dec. 2020. graf
Artigo em Inglês | LILACS-Express | LILACS, Coleciona SUS | ID: biblio-1142126


Abstract Dermatofibrosarcoma protuberans is a rare mesenchymal tumor; it is locally aggressive and presents high rates of local recurrence. It may present as a nodular or plaque vegetating lesion. It mainly affects the trunk and proximal limbs, being rare in the distal extremities. Biopsy and immunohistochemistry help confirm the diagnosis. The authors report a case of dermatofibrosarcoma protuberans with plantar region involvement, a rare presentation. To the best of the authors' knowledge, only 11 cases of involvement of the feet were described in the international literature.

An. bras. dermatol ; 95(6): 714-720, Nov.-Dec. 2020. tab, graf
Artigo em Inglês | LILACS-Express | LILACS, Coleciona SUS | ID: biblio-1142130


Abstract Background: Mohs micrographic surgery is worldwide used for treating skin cancers. After obtaining tumor-free margins, choosing the most appropriate type of closure can be challenging. Objectives: Our aim was to associate type of surgical reconstructions after Mohs micrographic surgery with the characteristics of the tumors as histological subtype, anatomical localization and especially number of surgical stages to achieve complete excision of the tumour. Methods: Transversal, retrospective analyses of medical records. Compilation of data such as gender, age, tumor location, histological subtype, number of stages to achieve clear margins and type of repair used. Results: A total of 975 of facial and extra-facial cases were analyzed. Linear closure was the most common repair by far (39%) and was associated with the smallest number of Mohs micrographic surgery stages. This type of closure was also more common in most histological subtypes and anatomical locations studied. Using Poisson regression model, nose defects presented 39% higher frequency of other closure types than the frequency of primary repairs, when compared to defects in other anatomic sites (p< 0.05). Tumors with two or more stages had a 28.6% higher frequency of other closure types than those operated in a single stage (p< 0.05). Study limitations: Retrospective study with limitations in obtaining information from medical records. The choice of closure type can be a personal choice. Conclusions: Primary closure should not be forgotten especially in surgical defects with fewer stages and in non-aggressive histological subtypes in main anatomic sites where Mohs micrographic surgery is performed.

An. bras. dermatol ; 95(6): 757-759, Nov.-Dec. 2020. graf
Artigo em Inglês | LILACS-Express | LILACS, Coleciona SUS | ID: biblio-1142131


Abstract Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected.

An. bras. dermatol ; 95(6): 691-695, Nov.-Dec. 2020. graf
Artigo em Inglês | LILACS-Express | LILACS, Coleciona SUS | ID: biblio-1142133


Abstract Background: The mitotic index is no longer used to classify T1 melanoma patients into T1a and T1b, so it should not be used to indicate sentinel node biopsy in these patients. Objectives: To evaluate patients with T1 melanoma who underwent sentinel lymph node biopsy and to compare those who were classified as T1a with those classified T1b, according to the 7th and 8th Edition of the melanoma staging system, regarding a positive biopsy result. The authors also aimed to assess whether there is any difference in the results in both staging systems. Material and methods: This was a retrospective analysis of 1213 patients who underwent sentinel lymph node biopsy for melanoma, from 2000 to 2015, in a single institution. Results: Of 399 patients with thin melanomas, 27 (6.7%) presented positive sentinel lymph nodes; there was no difference in positivity for sentinel node biopsy when comparing T1a vs. T1b in both staging systems. Furthermore, the clinical results were also similar between the two groups. However, in the complete cohort analysis, the mitotic index was associated with positivity for sentinel lymph node biopsy (p < 0.0001), positivity for non-sentinel lymph node (p < 0.0001), recurrence-free survival (p < 0.0001), and specific melanoma survival (p = 0.023). Study limitation: Unicentric study. Conclusion: The mitotic index was shown to be a very important prognostic factor in the present study, but it was not observed in patients classified as T1. The mitotic index should no longer be used as the only reason to refer sentinel lymph node biopsy in patients with thin melanoma.

Ciênc. Saúde Colet ; 25(12): 4945-4956, Dec. 2020. tab
Artigo em Português | LILACS, Coleciona SUS, Sec. Est. Saúde SP | ID: biblio-1142715


Resumo A pandemia de Covid-19 revelou a existência de ameaça concreta e imediata à segurança alimentar e nutricional (SAN), em especial de grupos vulnerabilizados. O estudo buscou identificar as estratégias governamentais implementadas no Brasil para prover o Direito Humano à Alimentação Adequada e Saudável em contextos de elevada vulnerabilidade social frente à Covid-19. Foi realizado um estudo transversal, com análise de documentos oficiais publicados entre 20 de março e 30 de julho de 2020 pela União, Distrito Federal, estados e capitais brasileiras, com foco em medidas que assegurem disponibilidade e acesso físico ou financeiro a alimentos. As estratégias implementadas envolvem fundamentalmente distribuição de alimentos e garantia de renda mínima. Foram instituídas: Renda Básica Emergencial (União); Programa de Aquisição de Alimentos (PAA) e auxílio financeiro emergencial (estados); programas de doação emergencial de alimentos (estados e municípios). Medidas existentes foram adaptadas frente à pandemia, como o Programa Nacional de Alimentação Escolar (PNAE), o Programa de Aquisição de Alimentos (PAA) nacional, a distribuição de alimentos e de cestas básicas. Embora importantes, essas estratégias têm alcance limitado e são insuficientes para assegurar a SAN.

Abstract The Covid-19 pandemic revealed a concrete and immediate threat to food and nutrition security (FNS), especially for vulnerable groups. This study aimed to identify government strategies implemented in Brazil to provide the Human Right to Adequate and Healthy Food in high social vulnerability contexts during the Covid-19 pandemic. A cross-sectional study was carried out, with analysis of official documents published between March 20 and July 30, 2020, by the Federal Government, Federal District, Brazilian states, and capitals, focusing on measures to ensure availability and physical or financial access to food. Strategies implemented mainly involve food distribution and minimum income assurance. The following were implemented: Basic Emergency Income (Federal Government); Food Acquisition Program (PAA), and emergency financial aid (states); emergency food donation programs (states and municipalities). Existing measures were adapted to the pandemic, such as the National School Food Program (PNAE), the National Food Acquisition Program (PAA), and the distribution of food and staple food baskets. While essential, these strategies have limited scope and are insufficient to ensure FNS.

Humanos , Infecções por Coronavirus/epidemiologia , Pandemias , Abastecimento de Alimentos/legislação & jurisprudência , Betacoronavirus , Brasil/epidemiologia , Áreas de Pobreza , Estudos Transversais , Regulamentação Governamental , Emergências , Assistência Alimentar/legislação & jurisprudência , Assistência Alimentar/organização & administração , Financiamento Governamental/legislação & jurisprudência , Abastecimento de Alimentos , Abastecimento de Alimentos/economia , Abastecimento de Alimentos/métodos , Dieta Saudável , Renda , Programas Nacionais de Saúde/legislação & jurisprudência , Programas Nacionais de Saúde/organização & administração
Ciênc. Saúde Colet ; 25(11): 4347-4350, nov. 2020. tab, graf
Artigo em Inglês | LILACS-Express | LILACS, Coleciona SUS, Sec. Est. Saúde SP | ID: biblio-1133029


Abstract On 31st May of every year, in honour of the 'World No Tobacco Day (WNTD),' the international community does organise various events and encourages avoiding all forms of Tobacco consumption. To commemorate WNTD-2018, the World Health Organization (WHO) has promoted awareness to highlight the link between Tobacco and cardiovascular disease (CVD). Because, Tobacco use is the second leading cause of CVD, after high blood pressure. In addition to CVD, Tobacco use is also known to cause many non-communicable diseases, including chronic obstructive pulmonary disease (COPD), lung cancer and other complicated disorders caused by smoking. In fact, non-communicable diseases are now emerging as the primary disease burden. Globally, Tobacco use kills about 7 million people each year, and if the trend remains the same, then it will kill more than 8 million people per year by 2030. On the contrary, despite promoting awareness, the Tobacco industry is growing with little or no regulation. However, in the long run, the global community will not be able to afford business as usual as Tobacco has a direct impact on human health, environmental health and sustainable development.

Resumo No dia 31 de maio de cada ano, em homenagem ao Dia Mundial Sem Tabaco (WNTD), a comunidade internacional organiza vários eventos e incentiva a evitar todas as formas de consumo de tabaco. Para comemorar o WNTD-2018, a Organização Mundial da Saúde (OMS) promoveu a conscientização para destacar a ligação entre o tabaco e as doenças cardiovasculares (DCV). Porque, o uso do tabaco é a segunda principal causa de DCV, após a hipertensão arterial. Além do DCV, o uso de tabaco também é conhecido por causar muitas doenças não transmissíveis, incluindo doença pulmonar obstrutiva crônica (DPOC), câncer de pulmão e outros transtornos complicados. De fato, as doenças não transmissíveis estão emergindo como a carga primária da doença. Globalmente, o consumo de tabaco mata cerca de 7 milhões de pessoas a cada ano, e se a tendência permanecer a mesma, matará mais de 8 milhões de pessoas por ano até 2030. Pelo contrário, apesar de promover a conscientização, a indústria do tabaco está crescendo com pouco ou sem regulamentação. No entanto, a longo prazo, a comunidade global não poderá se dar bem, pois o tabaco tem um impacto direto na saúde humana, na saúde ambiental e no desenvolvimento sustentável.

An. bras. dermatol ; 95(5): 615-618, Sept.-Oct. 2020. graf
Artigo em Inglês | LILACS-Express | LILACS, Coleciona SUS | ID: biblio-1130930


Abstract Biological therapies, including anti-TNF agents, are important in the treatment of various chronic inflammatory diseases, including psoriasis, rheumatoid arthritis or inflammatory bowel disease. The increased use of these drugs translates into an increasing awareness of its adverse effects, which include malignancy. In this paper, we describe the case of a 28-year-old woman who developed a spitzoid melanocytic tumor after starting infliximab therapy for ulcerative colitis. The evidence for causality between anti-TNF and melanocytic proliferations is still sparse; nonetheless, treatment-associated immunosuppression seems to play a key role in this phenomenon. Therefore, a regular follow-up with a rigorous skin examination is essential in these patients. Noninvasive techniques such as dermoscopy or reflectance confocal microscopy are particularly useful diagnostic tools in these circumstances.